ID   SBP1_XENTR              Reviewed;         472 AA.
AC   Q569D5;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Methanethiol oxidase {ECO:0000250|UniProtKB:Q13228};
DE            Short=MTO {ECO:0000250|UniProtKB:Q13228};
DE            EC=1.8.3.4 {ECO:0000250|UniProtKB:Q13228};
DE   AltName: Full=Selenium-binding protein 1;
GN   Name=selenbp1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the oxidation of methanethiol, an organosulfur
CC       compound known to be produced in substantial amounts by gut bacteria
CC       (By similarity). Selenium-binding protein which may be involved in the
CC       sensing of reactive xenobiotics in the cytoplasm. May be involved in
CC       intra-Golgi protein transport (By similarity).
CC       {ECO:0000250|UniProtKB:Q13228, ECO:0000250|UniProtKB:Q8VIF7}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + methanethiol + O2 = formaldehyde + H(+) + H2O2 +
CC         hydrogen sulfide; Xref=Rhea:RHEA:11812, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16007,
CC         ChEBI:CHEBI:16240, ChEBI:CHEBI:16842, ChEBI:CHEBI:29919; EC=1.8.3.4;
CC         Evidence={ECO:0000250|UniProtKB:Q13228};
CC   -!- PATHWAY: Organosulfur degradation. {ECO:0000250|UniProtKB:Q13228}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13228}.
CC       Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q13228}. Membrane
CC       {ECO:0000250|UniProtKB:Q8VIF7}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q8VIF7}.
CC   -!- SIMILARITY: Belongs to the selenium-binding protein family.
CC       {ECO:0000305}.
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DR   EMBL; BC092556; AAH92556.1; -; mRNA.
DR   RefSeq; NP_001016750.1; NM_001016750.3.
DR   AlphaFoldDB; Q569D5; -.
DR   SMR; Q569D5; -.
DR   STRING; 8364.ENSXETP00000058307; -.
DR   PRIDE; Q569D5; -.
DR   Ensembl; ENSXETT00000044773; ENSXETP00000044773; ENSXETG00000020722.
DR   GeneID; 549504; -.
DR   KEGG; xtr:549504; -.
DR   CTD; 8991; -.
DR   Xenbase; XB-GENE-959074; selenbp1.
DR   eggNOG; KOG0918; Eukaryota.
DR   InParanoid; Q569D5; -.
DR   OrthoDB; 483905at2759; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000020722; Expressed in mesonephros and 16 other tissues.
DR   ExpressionAtlas; Q569D5; differential.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0018549; F:methanethiol oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008430; F:selenium binding; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR008826; Se-bd.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR23300; PTHR23300; 1.
DR   Pfam; PF05694; SBP56; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Nucleus; Oxidoreductase; Protein transport;
KW   Reference proteome; Selenium; Transport.
FT   CHAIN           1..472
FT                   /note="Methanethiol oxidase"
FT                   /id="PRO_0000289067"
SQ   SEQUENCE   472 AA;  52660 MW;  6939A7D7BD13229F CRC64;
     MAKCGSCGPG YKTPLDAMKG PREEILYLPC IYRNTGINKP DYLATVDVNP KSPKYSQVIH
     RLPMPNTNDE LHHSGWNTCS SCYGDASKVR NKLILPCLIS SRIYVVDVGT DPRAPRIHKT
     VEPYEVFWKC GLANLHTSHC LGCGEIMISS IGDPYGNGKG GFVLLDGETF EVKGNWEAEG
     EAAPFGYDFW YQPRHNVMIS TEWGAPKAFA LGFKMEEVQA GMYGHSLNVW DWTEHRRIQT
     IDLGEDGLIP LEIRFLHDPD AAQGLVGCAL SSTVFRFYKE KDGKWAAEKV IKVPSKKVEG
     WALPEMPGLI TDILISLDDR FLYFSNWLHG DIRQYDITDP RNPKLVGQIF LGGSILRGGP
     VTVLEDKDLE CQPDPVIVKG KKVPGGPQMI QLSLDGKRLY VTNSLYSKWD KQFYPDMIKE
     GSVMLQIDVD TEKGGLKLNP NFLVDFGKEP GGPVLAHELR YPGGDCSSDI WV