SBP2L_HUMAN
ID SBP2L_HUMAN Reviewed; 1101 AA.
AC Q93073; Q8N767;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 3.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Selenocysteine insertion sequence-binding protein 2-like;
DE Short=SECIS-binding protein 2-like;
GN Name=SECISBP2L; Synonyms=KIAA0256;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Aortic endothelium;
RX PubMed=9039502; DOI=10.1093/dnares/3.5.321;
RA Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O.,
RA Tanaka A., Kotani H., Miyajima N., Nomura N.;
RT "Prediction of the coding sequences of unidentified human genes. VI. The
RT coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of
RT cDNA clones from cell line KG-1 and brain.";
RL DNA Res. 3:321-329(1996).
RN [2]
RP SEQUENCE REVISION.
RA Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O.,
RA Tanaka A., Kotani H., Miyajima N., Nomura N.;
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP BINDING TO SECIS ELEMENTS, LACK OF FUNCTION IN SEC INCORPORATION, AND
RP MUTAGENESIS OF GLY-721.
RX PubMed=22530054; DOI=10.1371/journal.pone.0035581;
RA Donovan J., Copeland P.R.;
RT "Selenocysteine insertion sequence binding protein 2L is implicated as a
RT novel post-transcriptional regulator of selenoprotein expression.";
RL PLoS ONE 7:E35581-E35581(2012).
CC -!- FUNCTION: Binds SECIS (Sec insertion sequence) elements present on
CC selenocysteine (Sec) protein mRNAs, but does not promote Sec
CC incorporation into selenoproteins in vitro.
CC -!- INTERACTION:
CC Q93073; Q96FJ2: DYNLL2; NbExp=3; IntAct=EBI-2805647, EBI-742371;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q93073-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q93073-2; Sequence=VSP_016342;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA13386.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; D87445; BAA13386.3; ALT_INIT; mRNA.
DR EMBL; BC033001; AAH33001.1; -; mRNA.
DR CCDS; CCDS32234.1; -. [Q93073-2]
DR CCDS; CCDS53942.1; -. [Q93073-1]
DR RefSeq; NP_001180418.1; NM_001193489.1. [Q93073-1]
DR RefSeq; NP_055516.2; NM_014701.3. [Q93073-2]
DR AlphaFoldDB; Q93073; -.
DR SMR; Q93073; -.
DR BioGRID; 115077; 24.
DR IntAct; Q93073; 10.
DR MINT; Q93073; -.
DR STRING; 9606.ENSP00000453854; -.
DR iPTMnet; Q93073; -.
DR PhosphoSitePlus; Q93073; -.
DR BioMuta; SECISBP2L; -.
DR DMDM; 59803102; -.
DR EPD; Q93073; -.
DR jPOST; Q93073; -.
DR MassIVE; Q93073; -.
DR MaxQB; Q93073; -.
DR PaxDb; Q93073; -.
DR PeptideAtlas; Q93073; -.
DR PRIDE; Q93073; -.
DR ProteomicsDB; 75699; -. [Q93073-1]
DR ProteomicsDB; 75700; -. [Q93073-2]
DR Antibodypedia; 50609; 10 antibodies from 8 providers.
DR DNASU; 9728; -.
DR Ensembl; ENST00000261847.7; ENSP00000261847.3; ENSG00000138593.9. [Q93073-2]
DR Ensembl; ENST00000559471.6; ENSP00000453854.1; ENSG00000138593.9. [Q93073-1]
DR GeneID; 9728; -.
DR KEGG; hsa:9728; -.
DR MANE-Select; ENST00000559471.6; ENSP00000453854.1; NM_001193489.2; NP_001180418.1.
DR UCSC; uc001zxd.4; human. [Q93073-1]
DR CTD; 9728; -.
DR DisGeNET; 9728; -.
DR GeneCards; SECISBP2L; -.
DR HGNC; HGNC:28997; SECISBP2L.
DR HPA; ENSG00000138593; Tissue enhanced (brain).
DR MIM; 615756; gene.
DR neXtProt; NX_Q93073; -.
DR OpenTargets; ENSG00000138593; -.
DR PharmGKB; PA164725649; -.
DR VEuPathDB; HostDB:ENSG00000138593; -.
DR eggNOG; ENOG502QUP4; Eukaryota.
DR GeneTree; ENSGT00490000043356; -.
DR HOGENOM; CLU_009625_0_0_1; -.
DR InParanoid; Q93073; -.
DR OMA; CAMNVVE; -.
DR PhylomeDB; Q93073; -.
DR TreeFam; TF328821; -.
DR PathwayCommons; Q93073; -.
DR SignaLink; Q93073; -.
DR BioGRID-ORCS; 9728; 18 hits in 1081 CRISPR screens.
DR ChiTaRS; SECISBP2L; human.
DR GenomeRNAi; 9728; -.
DR Pharos; Q93073; Tdark.
DR PRO; PR:Q93073; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q93073; protein.
DR Bgee; ENSG00000138593; Expressed in corpus callosum and 213 other tissues.
DR ExpressionAtlas; Q93073; baseline and differential.
DR Genevisible; Q93073; HS.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0035368; F:selenocysteine insertion sequence binding; IBA:GO_Central.
DR GO; GO:0001514; P:selenocysteine incorporation; IBA:GO_Central.
DR Gene3D; 3.30.1330.30; -; 1.
DR InterPro; IPR029064; L30e-like.
DR InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR InterPro; IPR040051; SECISBP2.
DR PANTHER; PTHR13284; PTHR13284; 1.
DR Pfam; PF01248; Ribosomal_L7Ae; 1.
DR SUPFAM; SSF55315; SSF55315; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..1101
FT /note="Selenocysteine insertion sequence-binding protein 2-
FT like"
FT /id="PRO_0000050739"
FT REGION 154..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 884..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1030..1101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..375
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..907
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..939
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 952..985
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1004
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1044..1059
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1068..1101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 276
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6A098"
FT VAR_SEQ 346..390
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9039502"
FT /id="VSP_016342"
FT MUTAGEN 721
FT /note="G->R: Loss of binding to SELV and TXNRD1 SECIS
FT elements."
FT /evidence="ECO:0000269|PubMed:22530054"
FT CONFLICT 756
FT /note="L -> F (in Ref. 3; AAH33001)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1101 AA; 121776 MW; C946BC473619FF6D CRC64;
MDRAPTEQNV KLSAEVEPFI PQKKSPDTFM IPMALPNDNG SVSGVEPTPI PSYLITCYPF
VQENQSNRQF PLYNNDIRWQ QPNPNPTGPY FAYPIISAQP PVSTEYTYYQ LMPAPCAQVM
GFYHPFPTPY SNTFQAANTV NAITTECTER PSQLGQVFPL SSHRSRNSNR GSVVPKQQLL
QQHIKSKRPL VKNVATQKET NAAGPDSRSK IVLLVDASQQ TDFPSDIANK SLSETTATML
WKSKGRRRRA SHPTAESSSE QGASEADIDS DSGYCSPKHS NNQPAAGALR NPDSGTMNHV
ESSMCAGGVN WSNVTCQATQ KKPWMEKNQT FSRGGRQTEQ RNNSQVGFRC RGHSTSSERR
QNLQKRPDNK HLSSSQSHRS DPNSESLYFE DEDGFQELNE NGNAKDENIQ QKLSSKVLDD
LPENSPINIV QTPIPITTSV PKRAKSQKKK ALAAALATAQ EYSEISMEQK KLQEALSKAA
GKKNKTPVQL DLGDMLAALE KQQQAMKARQ ITNTRPLSYT VVTAASFHTK DSTNRKPLTK
SQPCLTSFNS VDIASSKAKK GKEKEIAKLK RPTALKKVIL KEREEKKGRL TVDHNLLGSE
EPTEMHLDFI DDLPQEIVSQ EDTGLSMPSD TSLSPASQNS PYCMTPVSQG SPASSGIGSP
MASSTITKIH SKRFREYCNQ VLCKEIDECV TLLLQELVSF QERIYQKDPV RAKARRRLVM
GLREVTKHMK LNKIKCVIIS PNCEKIQSKG GLDEALYNVI AMAREQEIPF VFALGRKALG
RCVNKLVPVS VVGIFNYFGA ESLFNKLVEL TEEARKAYKD MVAAMEQEQA EEALKNVKKV
PHHMGHSRNP SAASAISFCS VISEPISEVN EKEYETNWRN MVETSDGLEA SENEKEVSCK
HSTSEKPSKL PFDTPPIGKQ PSLVATGSTT SATSAGKSTA SDKEEVKPDD LEWASQQSTE
TGSLDGSCRD LLNSSITSTT STLVPGMLEE EEDEDEEEEE DYTHEPISVE VQLNSRIESW
VSETQRTMET LQLGKTLNGS EEDNVEQSGE EEAEAPEVLE PGMDSEAWTA DQQASPGQQK
SSNCSSLNKE HSDSNYTTQT T
