SBP2L_MOUSE
ID SBP2L_MOUSE Reviewed; 1086 AA.
AC Q6A098;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 2.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Selenocysteine insertion sequence-binding protein 2-like;
DE Short=SECIS-binding protein 2-like;
GN Name=Secisbp2l; Synonyms=Kiaa0256;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreatic islet;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Liver, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Binds SECIS (Sec insertion sequence) elements present on
CC selenocysteine (Sec) protein mRNAs, but does not promote Sec
CC incorporation into selenoproteins. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD32198.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK172920; BAD32198.1; ALT_INIT; Transcribed_RNA.
DR AlphaFoldDB; Q6A098; -.
DR SMR; Q6A098; -.
DR STRING; 10090.ENSMUSP00000055772; -.
DR iPTMnet; Q6A098; -.
DR PhosphoSitePlus; Q6A098; -.
DR EPD; Q6A098; -.
DR jPOST; Q6A098; -.
DR MaxQB; Q6A098; -.
DR PaxDb; Q6A098; -.
DR PRIDE; Q6A098; -.
DR ProteomicsDB; 255339; -.
DR MGI; MGI:1917604; Secisbp2l.
DR eggNOG; ENOG502QUP4; Eukaryota.
DR InParanoid; Q6A098; -.
DR ChiTaRS; Secisbp2l; mouse.
DR PRO; PR:Q6A098; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q6A098; protein.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IBA:GO_Central.
DR GO; GO:0035368; F:selenocysteine insertion sequence binding; IBA:GO_Central.
DR GO; GO:0001514; P:selenocysteine incorporation; IBA:GO_Central.
DR Gene3D; 3.30.1330.30; -; 1.
DR InterPro; IPR029064; L30e-like.
DR InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR InterPro; IPR040051; SECISBP2.
DR PANTHER; PTHR13284; PTHR13284; 1.
DR Pfam; PF01248; Ribosomal_L7Ae; 1.
DR SUPFAM; SSF55315; SSF55315; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..1086
FT /note="Selenocysteine insertion sequence-binding protein 2-
FT like"
FT /id="PRO_0000050740"
FT REGION 155..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 919..1086
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..997
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1023
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1057..1086
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 276
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355"
SQ SEQUENCE 1086 AA; 119641 MW; E016F2E4E207DF52 CRC64;
MDRAPAEQNV KLSAEVEPFV PQKKNLDAFV LPMALPSDNG SVSGVEPTPI PSYLITCYPF
VQENQSNRQF PLYNNDIRWQ QPSPSPTGPY LAYPIISAQP PVSTEYTYYQ LMPAPCAQVM
GFYHPFPTPY SSTFQAANTV NAISTECTER PNQLGQAFPL SSHRSRNGNR GPVVPKPQLL
QQHIKNKRPQ VKNVATQKET SATGPDSRSK IVLLVDASQQ TDFPSDIANK SLSESTATML
WKAKGRRRRA SHPAVESSSE QGASEADIDS DSGYCSPKHN NQSAPGALRD PASGTMNRLE
SSGCSGGVNW PKVTCQATQK RPWMEKNQAF SRGGRQTEQR NNLQVGFRCR GHSTSSERRQ
NLQKRQDNKH LNSTQSHRSD PNSESLYFED EDGFQELSEN GNSKDENIQQ KLSSKVLDDL
PENSPINIVQ TPIPITTSVP KRAKSQKKKA LAAALATAQE YSEISKKSCR KLYQKQLEKT
KTPVQLDLGD MLAALEKQQQ AMKARQITNT RPLAHPVVTT ATFHTKDSNR KTLAKSQPCV
TSFNSLDITS SKAKKGKEKE IAKLKRPTAL KKVILKEREE KKGRLIVEHS VLGAEEPTET
HLDLTNDLPQ ETVSQEDAGL SMPSDASLSP ASQNSPYCMT PVSQGSPASS GIGSPMASST
ITKIHSKRFR EYCNQVLSKE IDECVTLLLQ ELVSFQERIY QKDPVRAKAR RRLVMGLREV
TKHMKLNKIK CVIISPNCEK IQSKGGLDEA LYNVIAMARE QEIPFVFALG RKALGRCVNK
LVPVSVVGIF NYFGAESLFN RLVELTEEAR KAYKDMVAAT EQEQAEEALR SVKTVPHHMG
HSRNPSAASA ISFCSVISEP ISEVNEKEYE TNWRSMVETS DGLEPSEMEK AAPCTHSPPE
KPSRLALDTS LVGKQLPLAA GSITSAPSQG KPTGDKDELK PDDLEWASQQ STETGSLDGS
CRDLLNSSIT STTSTLVPGM LEEEEDEEEE EEDYSHEPTA EEVQLNSRIE SWVSETQRTM
ETLQLGKALP GSEEDSAEQS GEEAAEVPEG LESGADSETW TPDQPPKPSS NMGKEHPDSS
SPPQST
