SBSN_MOUSE
ID SBSN_MOUSE Reviewed; 700 AA.
AC Q8CIT9; Q6SZK0; Q80WB4; Q8K2V9;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Suprabasin;
DE Flags: Precursor;
GN Name=Sbsn;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, INDUCTION,
RP AND TISSUE SPECIFICITY.
RC STRAIN=129/SvJ; TISSUE=Keratinocyte;
RX PubMed=12228223; DOI=10.1074/jbc.m205380200;
RA Park G.T., Lim S.E., Jang S.-I., Morasso M.I.;
RT "Suprabasin, a novel epidermal differentiation marker and potential
RT cornified envelope precursor.";
RL J. Biol. Chem. 277:45195-45202(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC STRAIN=CD-1; TISSUE=Embryonic limb, and Embryonic skin;
RX PubMed=15256262; DOI=10.1016/j.gene.2004.03.010;
RA Moffatt P., Salois P., St Amant N., Gaumond M.-H., Lanctot C.;
RT "Identification of a conserved cluster of skin-specific genes encoding
RT secreted proteins.";
RL Gene 334:123-131(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=FVB/N-3; TISSUE=Mammary gland, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15256262}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CIT9-1; Sequence=Displayed;
CC Name=3; Synonyms=Short;
CC IsoId=Q8CIT9-3; Sequence=VSP_030902;
CC -!- TISSUE SPECIFICITY: Detected in epidermis, in suprabasal keratinocytes.
CC Detected in suprabasal layers of embryonic epidermis and in stratified
CC layers of embryonic tongue and palate. Detected in adult stomach.
CC {ECO:0000269|PubMed:12228223, ECO:0000269|PubMed:15256262}.
CC -!- DEVELOPMENTAL STAGE: First detected after 15 days of embryonic
CC development, and highly expressed after 17 days, coinciding with
CC stratification of epidermis.
CC -!- INDUCTION: Up-regulated in differentiating keratinocytes.
CC {ECO:0000269|PubMed:12228223}.
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DR EMBL; AY115494; AAM75407.1; -; mRNA.
DR EMBL; AY444556; AAR20795.1; -; mRNA.
DR EMBL; BC051531; AAH51531.1; -; mRNA.
DR EMBL; BC092350; AAH92350.1; -; mRNA.
DR CCDS; CCDS59725.1; -. [Q8CIT9-3]
DR RefSeq; NP_001077372.1; NM_001083903.1.
DR AlphaFoldDB; Q8CIT9; -.
DR BioGRID; 235036; 4.
DR STRING; 10090.ENSMUSP00000079362; -.
DR PhosphoSitePlus; Q8CIT9; -.
DR MaxQB; Q8CIT9; -.
DR PeptideAtlas; Q8CIT9; -.
DR PRIDE; Q8CIT9; -.
DR ProteomicsDB; 255340; -. [Q8CIT9-1]
DR ProteomicsDB; 255341; -. [Q8CIT9-3]
DR GeneID; 282619; -.
DR KEGG; mmu:282619; -.
DR UCSC; uc009ggf.1; mouse. [Q8CIT9-3]
DR CTD; 374897; -.
DR MGI; MGI:2446326; Sbsn.
DR eggNOG; ENOG502SGZY; Eukaryota.
DR InParanoid; Q8CIT9; -.
DR BioGRID-ORCS; 282619; 2 hits in 75 CRISPR screens.
DR ChiTaRS; Sbsn; mouse.
DR PRO; PR:Q8CIT9; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8CIT9; protein.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..700
FT /note="Suprabasin"
FT /id="PRO_0000317121"
FT REGION 133..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 488..546
FT /evidence="ECO:0000255"
FT COMPBIAS 641..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 119..654
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15256262,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_030902"
FT CONFLICT 96
FT /note="N -> S (in Ref. 3; AAH51531)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 700 AA; 72334 MW; E514974A14C947AD CRC64;
MYLVSLLSSC CLLVLLGTLP ARAAHEDPVE KVIEGFSRGL SNAEREVGKA LEGINNGITQ
AGREVEKIFG ELSNMGSQAG KNVEHGLDKV AHDINNGIGH AGKEAEKFAH GVNHAAGQVG
KETNKIIHHG VSQGGSEAGK FGQGSHHAFG QGGNVANKLG HETHHAFGQG GNVAHKLGHE
THHAFGQGGN VADKLGHGGN VADKLGHGTH HAFGQGGNVA DKLGHETHHA FGQGGNVADK
LGHGTHHAFG QGGNVADKLG HETHHAFGQG GNVAEKLGHE THHAFGQGGN MADKFGQGAH
HAFGQGGNMA DKFGQGAHHA FGQGGNMADK FGQGAHHAFG QGGNMADKFG QGAHHAFGQG
GNMADKFGQG AHHAFGQGGN MADKFGQGAH HAFGQGRDMA ETFDQGAHHA FGQGGREGGR
LVQGAGQGLS HAAKEAQQFG HGHGHGYYAA GQTWQEGDKV IHPGVSQAGE EMEQFGQGVR
HTIKQAEKEA EKVAHGVQNG VNQAQKEAEK VAHGVQNGVN QAQKEAEKVA HGVQNGVNQA
QKEAEKVAHG VQTGVNQAGK ETQRVGQGVQ TGFNQGQKEA EKVAHGVQTG VNQAGKETQK
AGQGVNYAAG QAEKEAEKLG QGVHHAAGQE MNRLQQDVHN GVNQPSKEAN QLLNGSHQGQ
GGYGGQHGGA ATTTVVSGAS VNKPFINFPA LWRSIAATMP
