ID   SBSPO_BOVIN             Reviewed;         264 AA.
AC   Q32L50;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Somatomedin-B and thrombospondin type-1 domain-containing protein;
DE   AltName: Full=RPE-spondin;
DE   Flags: Precursor;
GN   Name=SBSPON; Synonyms=RPESP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the thrombospondin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC109766; AAI09767.2; -; mRNA.
DR   RefSeq; NP_001069337.1; NM_001075869.2.
DR   AlphaFoldDB; Q32L50; -.
DR   STRING; 9913.ENSBTAP00000022924; -.
DR   PaxDb; Q32L50; -.
DR   Ensembl; ENSBTAT00000022924; ENSBTAP00000022924; ENSBTAG00000017249.
DR   GeneID; 525332; -.
DR   KEGG; bta:525332; -.
DR   CTD; 157869; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017249; -.
DR   VGNC; VGNC:34311; SBSPON.
DR   eggNOG; ENOG502QV8I; Eukaryota.
DR   GeneTree; ENSGT00390000008325; -.
DR   HOGENOM; CLU_058116_1_1_1; -.
DR   InParanoid; Q32L50; -.
DR   OMA; QAASPQW; -.
DR   OrthoDB; 915522at2759; -.
DR   TreeFam; TF315634; -.
DR   Reactome; R-BTA-5173214; O-glycosylation of TSR domain-containing proteins.
DR   Proteomes; UP000009136; Chromosome 14.
DR   Bgee; ENSBTAG00000017249; Expressed in trachea and 92 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.100.10; -; 1.
DR   InterPro; IPR039942; SBSPO.
DR   InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR   InterPro; IPR001212; Somatomedin_B_dom.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR044004; TSP1_spondin_dom.
DR   PANTHER; PTHR20920; PTHR20920; 1.
DR   Pfam; PF19028; TSP1_spondin; 1.
DR   SUPFAM; SSF82895; SSF82895; 1.
DR   SUPFAM; SSF90188; SSF90188; 1.
DR   PROSITE; PS00524; SMB_1; 1.
DR   PROSITE; PS50958; SMB_2; 1.
DR   PROSITE; PS50092; TSP1; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Extracellular matrix; Glycoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..264
FT                   /note="Somatomedin-B and thrombospondin type-1 domain-
FT                   containing protein"
FT                   /id="PRO_0000332157"
FT   DOMAIN          24..75
FT                   /note="SMB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT   DOMAIN          74..127
FT                   /note="TSP type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   CARBOHYD        227
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        28..52
FT                   /note="Alternate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT   DISULFID        28..36
FT                   /note="Alternate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT   DISULFID        36..70
FT                   /note="Alternate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT   DISULFID        50..63
FT                   /note="Alternate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT   DISULFID        50..52
FT                   /note="Alternate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT   DISULFID        56..62
FT                   /evidence="ECO:0000250"
FT   DISULFID        63..70
FT                   /note="Alternate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
SQ   SEQUENCE   264 AA;  29310 MW;  53DCF7A2A6B7C664 CRC64;
     MRTLWMALCV LARLWPGALA GCADAGRCCP GRDPACFASG WRQDRVYGTC FCDQACRLTG
     DCCFDYARAC PARPCIVGEW SPWSGCASQC RPTARVRRRA VQQEPQNGGE PCPALEERAG
     CLEYATPQGE DCGHAFVPAF ITTSAFNKER TRQAASPHWT TSTEDAGYCM EFKTESLTHH
     CALENRPLTR WMQYLREGYT VCVDCQPPAM NSVSLRCSGD GLDSDGNQTL HWQAIGNPRC
     QGTWKKVRRV EQCSCPAVHS FIFI