SBSPO_MOUSE
ID SBSPO_MOUSE Reviewed; 264 AA.
AC Q3UPR9; B2RVH7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Somatomedin-B and thrombospondin type-1 domain-containing protein;
DE AltName: Full=RPE-spondin;
DE Flags: Precursor;
GN Name=Sbspon; Synonyms=Gm106, Rpesp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Oviduct, and Urinary bladder;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the thrombospondin family. {ECO:0000305}.
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DR EMBL; AK137144; BAE23250.1; -; mRNA.
DR EMBL; AK143251; BAE25326.1; -; mRNA.
DR EMBL; BC147194; AAI47195.1; -; mRNA.
DR EMBL; BC147195; AAI47196.1; -; mRNA.
DR CCDS; CCDS14828.1; -.
DR RefSeq; NP_001028460.1; NM_001033288.3.
DR AlphaFoldDB; Q3UPR9; -.
DR STRING; 10090.ENSMUSP00000047730; -.
DR GlyGen; Q3UPR9; 1 site.
DR PhosphoSitePlus; Q3UPR9; -.
DR MaxQB; Q3UPR9; -.
DR PaxDb; Q3UPR9; -.
DR PRIDE; Q3UPR9; -.
DR ProteomicsDB; 256600; -.
DR Antibodypedia; 25155; 72 antibodies from 18 providers.
DR DNASU; 226866; -.
DR Ensembl; ENSMUST00000040695; ENSMUSP00000047730; ENSMUSG00000032719.
DR GeneID; 226866; -.
DR KEGG; mmu:226866; -.
DR UCSC; uc007ajj.1; mouse.
DR CTD; 157869; -.
DR MGI; MGI:2684952; Sbspon.
DR VEuPathDB; HostDB:ENSMUSG00000032719; -.
DR eggNOG; ENOG502QV8I; Eukaryota.
DR GeneTree; ENSGT00390000008325; -.
DR HOGENOM; CLU_058116_1_1_1; -.
DR InParanoid; Q3UPR9; -.
DR OMA; QAASPQW; -.
DR OrthoDB; 915522at2759; -.
DR PhylomeDB; Q3UPR9; -.
DR TreeFam; TF315634; -.
DR Reactome; R-MMU-5173214; O-glycosylation of TSR domain-containing proteins.
DR BioGRID-ORCS; 226866; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Sbspon; mouse.
DR PRO; PR:Q3UPR9; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q3UPR9; protein.
DR Bgee; ENSMUSG00000032719; Expressed in sciatic nerve and 107 other tissues.
DR Genevisible; Q3UPR9; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR Gene3D; 2.20.100.10; -; 1.
DR InterPro; IPR039942; SBSPO.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR044004; TSP1_spondin_dom.
DR PANTHER; PTHR20920; PTHR20920; 1.
DR Pfam; PF19028; TSP1_spondin; 1.
DR SUPFAM; SSF82895; SSF82895; 1.
DR SUPFAM; SSF90188; SSF90188; 1.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 1.
DR PROSITE; PS50092; TSP1; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Extracellular matrix; Glycoprotein; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..264
FT /note="Somatomedin-B and thrombospondin type-1 domain-
FT containing protein"
FT /id="PRO_0000332159"
FT DOMAIN 24..75
FT /note="SMB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT DOMAIN 74..125
FT /note="TSP type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT CARBOHYD 227
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 28..52
FT /note="Alternate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT DISULFID 28..36
FT /note="Alternate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT DISULFID 36..70
FT /note="Alternate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT DISULFID 50..63
FT /note="Alternate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT DISULFID 50..52
FT /note="Alternate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT DISULFID 56..62
FT /evidence="ECO:0000250"
FT DISULFID 63..70
FT /note="Alternate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
SQ SEQUENCE 264 AA; 29464 MW; C30DD59250267876 CRC64;
MKTLWMVLCA LARLWPGALA GCAEAGRCCP GRDPACFARG WRLDRVYGTC FCDQACRLTG
DCCFDYDRAC PARPCFVGEW SPWSGCAGQC QPTTRVRRRS VRQEPLNGGA PCPPLEERAG
CLEYSSSQSQ DCGHSFVPAF ITSSVFNKKR IIQAVSPQWS THTKDAGYCM EFKTESLTPH
CALVNSPLTR WMQYLREGYT VCVDCQPPAM NSVSLRCSGD GLDSDGNQTL RWQAIGNPRC
QGTWKKVRRV EQCSCPDVHR FIFI
