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SBT25_ARATH
ID   SBT25_ARATH             Reviewed;         815 AA.
AC   O64481;
DT   04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 162.
DE   RecName: Full=Subtilisin-like protease SBT2.5 {ECO:0000303|PubMed:16193095};
DE            EC=3.4.21.- {ECO:0000305};
DE   AltName: Full=Subtilase subfamily 2 member 5 {ECO:0000303|PubMed:16193095};
DE            Short=AtSBT2.5 {ECO:0000303|PubMed:16193095};
DE   AltName: Full=Subtilisin-like serine protease 3 {ECO:0000303|PubMed:12702015};
DE            Short=At-SLP3 {ECO:0000303|PubMed:12702015};
DE   Flags: Precursor;
GN   Name=SBT2.5 {ECO:0000303|PubMed:16193095};
GN   Synonyms=SLP3 {ECO:0000303|PubMed:12702015};
GN   OrderedLocusNames=At2g19170 {ECO:0000312|Araport:AT2G19170};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   TISSUE SPECIFICITY, AND INDUCTION BY METHYL JASMONATE.
RX   PubMed=12702015; DOI=10.1034/j.1399-3054.2003.00087.x;
RA   Golldack D., Vera P., Dietz K.J.;
RT   "Expression of subtilisin-like serine proteases in Arabidopsis thaliana is
RT   cell-specific and responds to jasmonic acid and heavy metals with
RT   developmental differences.";
RL   Physiol. Plantarum 118:64-73(2003).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16193095; DOI=10.1371/journal.pcbi.0010040;
RA   Rautengarten C., Steinhauser D., Bussis D., Stintzi A., Schaller A.,
RA   Kopka J., Altmann T.;
RT   "Inferring hypotheses on functional relationships of genes: Analysis of the
RT   Arabidopsis thaliana subtilase gene family.";
RL   PLoS Comput. Biol. 1:E40-E40(2005).
CC   -!- TISSUE SPECIFICITY: Expressed in roots, leaves and flowers of mature
CC       plants. {ECO:0000269|PubMed:12702015}.
CC   -!- INDUCTION: By methyl jasmonate. {ECO:0000269|PubMed:12702015}.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000305}.
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DR   EMBL; AC002392; AAD12040.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC06854.1; -; Genomic_DNA.
DR   EMBL; CP002685; ANM61987.1; -; Genomic_DNA.
DR   EMBL; AY051009; AAK93686.1; -; mRNA.
DR   EMBL; AY133826; AAM91760.1; -; mRNA.
DR   PIR; T00538; T00538.
DR   RefSeq; NP_001324171.1; NM_001335625.1.
DR   RefSeq; NP_565447.1; NM_127474.4.
DR   AlphaFoldDB; O64481; -.
DR   SMR; O64481; -.
DR   STRING; 3702.AT2G19170.1; -.
DR   MEROPS; S08.A02; -.
DR   PaxDb; O64481; -.
DR   PRIDE; O64481; -.
DR   ProteomicsDB; 232795; -.
DR   EnsemblPlants; AT2G19170.1; AT2G19170.1; AT2G19170.
DR   EnsemblPlants; AT2G19170.2; AT2G19170.2; AT2G19170.
DR   GeneID; 816434; -.
DR   Gramene; AT2G19170.1; AT2G19170.1; AT2G19170.
DR   Gramene; AT2G19170.2; AT2G19170.2; AT2G19170.
DR   KEGG; ath:AT2G19170; -.
DR   Araport; AT2G19170; -.
DR   TAIR; locus:2059052; AT2G19170.
DR   eggNOG; ENOG502QS8I; Eukaryota.
DR   HOGENOM; CLU_000625_3_1_1; -.
DR   InParanoid; O64481; -.
DR   OMA; DIRMIYF; -.
DR   OrthoDB; 337164at2759; -.
DR   PhylomeDB; O64481; -.
DR   PRO; PR:O64481; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; O64481; baseline and differential.
DR   Genevisible; O64481; AT.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0008236; F:serine-type peptidase activity; ISS:TAIR.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd04852; Peptidases_S8_3; 1.
DR   Gene3D; 3.30.70.80; -; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR034197; Peptidases_S8_3.
DR   InterPro; IPR010259; S8pro/Inhibitor_I9.
DR   InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR   InterPro; IPR045051; SBT.
DR   InterPro; IPR041469; Subtilisin-like_FN3.
DR   PANTHER; PTHR10795; PTHR10795; 1.
DR   Pfam; PF17766; fn3_6; 1.
DR   Pfam; PF05922; Inhibitor_I9; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Hydrolase; Protease; Reference proteome; Serine protease;
KW   Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..815
FT                   /note="Subtilisin-like protease SBT2.5"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000431967"
FT   DOMAIN          21..124
FT                   /note="Inhibitor I9"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          120..671
FT                   /note="Peptidase S8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   DOMAIN          397..501
FT                   /note="PA"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        160
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        234
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        596
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   CARBOHYD        503
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        577
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        701
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   815 AA;  87667 MW;  CD41FA92159AA200 CRC64;
     MDIGLRIFVV FVLLVAVTAE VYIVTMEGDP IISYKGGENG FEATAVESDE KIDTSSELVT
     VYARHLERKH DMILGMLFEE GSYKKLYSYK HLINGFAAHV SPEQAETLRR APGVRSVDKD
     WKVRRLTTHT PEFLGLPTDV WPTGGGFDRA GEDIVIGFVD SGIYPHHPSF ASHHRLPYGP
     LPHYKGKCEE DPHTKKSFCN RKIVGAQHFA EAAKAAGAFN PDIDYASPMD GDGHGSHTAA
     IAAGNNGIPL RMHGYEFGKA SGMAPRARIA VYKALYRLFG GFVADVVAAI DQAVHDGVDI
     LSLSVGPNSP PTTTKTTFLN PFDATLLGAV KAGVFVAQAA GNGGPFPKTL VSYSPWITTV
     AAAIDDRRYK NHLTLGNGKM LAGMGLSPPT RPHRLYTLVS ANDVLLDSSV SKYNPSDCQR
     PEVFNKKLVE GNILLCGYSF NFVVGTASIK KVVATAKHLG AAGFVLVVEN VSPGTKFDPV
     PSAIPGILIT DVSKSMDLID YYNASTSRDW TGRVKSFKAE GSIGDGLAPV LHKSAPQVAL
     FSARGPNTKD FSFQDADLLK PDILAPGYLI WAAWCPNGTD EPNYVGEGFA LISGTSMAAP
     HIAGIAALVK QKHPQWSPAA IKSALMTTST VIDRAGRLLQ AQQYSDTEAV TLVKATPFDY
     GSGHVNPSAA LDPGLIFDAG YEDYLGFLCT TPGISAHEIR NYTNTACNYD MKHPSNFNAP
     SIAVSHLVGT QTVTRKVTNV AEVEETYTIT ARMQPSIAIE VNPPAMTLRP GATRTFSVTM
     TVRSVSGVYS FGEVKLKGSR GHKVRIPVVA LGHRR
 
 
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