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SBT_MEDTR
ID   SBT_MEDTR               Reviewed;         748 AA.
AC   G7KEU7;
DT   17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Subtilisin-like protease {ECO:0000303|PubMed:12953114};
DE            Short=Subtilase {ECO:0000303|PubMed:12953114};
DE            EC=3.4.21.- {ECO:0000255|PROSITE-ProRule:PRU10080};
DE   Flags: Precursor;
GN   Name=SBT {ECO:0000303|PubMed:12953114};
GN   OrderedLocusNames=MTR_5g011320 {ECO:0000312|EMBL:AES94154.1};
OS   Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX   NCBI_TaxID=3880;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Jemalong A17;
RX   PubMed=22089132; DOI=10.1038/nature10625;
RA   Young N.D., Debelle F., Oldroyd G.E.D., Geurts R., Cannon S.B.,
RA   Udvardi M.K., Benedito V.A., Mayer K.F.X., Gouzy J., Schoof H.,
RA   Van de Peer Y., Proost S., Cook D.R., Meyers B.C., Spannagl M., Cheung F.,
RA   De Mita S., Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K.,
RA   Murray J.D., Naoumkina M.A., Rosen B., Silverstein K.A.T., Tang H.,
RA   Rombauts S., Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M.,
RA   Bellec A., Berger A., Berges H., Bidwell S., Bisseling T., Choisne N.,
RA   Couloux A., Denny R., Deshpande S., Dai X., Doyle J.J., Dudez A.-M.,
RA   Farmer A.D., Fouteau S., Franken C., Gibelin C., Gish J., Goldstein S.,
RA   Gonzalez A.J., Green P.J., Hallab A., Hartog M., Hua A., Humphray S.J.,
RA   Jeong D.-H., Jing Y., Jocker A., Kenton S.M., Kim D.-J., Klee K., Lai H.,
RA   Lang C., Lin S., Macmil S.L., Magdelenat G., Matthews L., McCorrison J.,
RA   Monaghan E.L., Mun J.-H., Najar F.Z., Nicholson C., Noirot C.,
RA   O'Bleness M., Paule C.R., Poulain J., Prion F., Qin B., Qu C., Retzel E.F.,
RA   Riddle C., Sallet E., Samain S., Samson N., Sanders I., Saurat O.,
RA   Scarpelli C., Schiex T., Segurens B., Severin A.J., Sherrier D.J., Shi R.,
RA   Sims S., Singer S.R., Sinharoy S., Sterck L., Viollet A., Wang B.-B.,
RA   Wang K., Wang M., Wang X., Warfsmann J., Weissenbach J., White D.D.,
RA   White J.D., Wiley G.B., Wincker P., Xing Y., Yang L., Yao Z., Ying F.,
RA   Zhai J., Zhou L., Zuber A., Denarie J., Dixon R.A., May G.D.,
RA   Schwartz D.C., Rogers J., Quetier F., Town C.D., Roe B.A.;
RT   "The Medicago genome provides insight into the evolution of rhizobial
RT   symbioses.";
RL   Nature 480:520-524(2011).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Jemalong A17;
RX   PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA   Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA   Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA   Schwartz D.C., Town C.D.;
RT   "An improved genome release (version Mt4.0) for the model legume Medicago
RT   truncatula.";
RL   BMC Genomics 15:312-312(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-228, AND INDUCTION BY GLOMUS VERSIFORME.
RC   STRAIN=cv. Jemalong A17;
RX   PubMed=12953114; DOI=10.1105/tpc.014183;
RA   Liu J., Blaylock L.A., Endre G., Cho J., Town C.D., VandenBosch K.A.,
RA   Harrison M.J.;
RT   "Transcript profiling coupled with spatial expression analyses reveals
RT   genes involved in distinct developmental stages of an arbuscular
RT   mycorrhizal symbiosis.";
RL   Plant Cell 15:2106-2123(2003).
CC   -!- FUNCTION: Required for arbuscular mycorrhiza (AM) development during AM
CC       symbiosis with AM fungi (e.g. Glomeromycota intraradices).
CC       {ECO:0000250|UniProtKB:A9QY40}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, apoplast
CC       {ECO:0000250|UniProtKB:A9QY40}. Note=Accumulates in the intercellular
CC       spaces and the periarbuscular space (PAS) during arbuscular mycorrhizal
CC       (AM) symbiosis. {ECO:0000250|UniProtKB:A9QY40}.
CC   -!- INDUCTION: Accumulates in mycorrhizal roots upon colonization by the
CC       arbuscular mycorrhiza (AM) fungus Glomus versiforme.
CC       {ECO:0000269|PubMed:12953114}.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01240}.
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DR   EMBL; CM001221; AES94154.1; -; Genomic_DNA.
DR   EMBL; AW584611; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_003611196.1; XM_003611148.1.
DR   AlphaFoldDB; G7KEU7; -.
DR   SMR; G7KEU7; -.
DR   STRING; 3880.AES94154; -.
DR   EnsemblPlants; AES94154; AES94154; MTR_5g011320.
DR   GeneID; 11443095; -.
DR   Gramene; AES94154; AES94154; MTR_5g011320.
DR   KEGG; mtr:MTR_5g011320; -.
DR   eggNOG; ENOG502QPQR; Eukaryota.
DR   HOGENOM; CLU_000625_4_6_1; -.
DR   OMA; VYPFHPS; -.
DR   OrthoDB; 337164at2759; -.
DR   Proteomes; UP000002051; Chromosome 5.
DR   GO; GO:0048046; C:apoplast; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0036377; P:arbuscular mycorrhizal association; ISS:UniProtKB.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0009610; P:response to symbiotic fungus; IEP:UniProtKB.
DR   CDD; cd04852; Peptidases_S8_3; 1.
DR   Gene3D; 3.30.70.80; -; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR034197; Peptidases_S8_3.
DR   InterPro; IPR010259; S8pro/Inhibitor_I9.
DR   InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR   InterPro; IPR045051; SBT.
DR   InterPro; IPR041469; Subtilisin-like_FN3.
DR   PANTHER; PTHR10795; PTHR10795; 1.
DR   Pfam; PF17766; fn3_6; 1.
DR   Pfam; PF05922; Inhibitor_I9; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
PE   2: Evidence at transcript level;
KW   Apoplast; Glycoprotein; Hydrolase; Protease; Reference proteome; Secreted;
KW   Serine protease; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..748
FT                   /note="Subtilisin-like protease"
FT                   /id="PRO_5014573578"
FT   DOMAIN          37..115
FT                   /note="Inhibitor I9"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          122..600
FT                   /note="Peptidase S8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   DOMAIN          365..454
FT                   /note="PA"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        147
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        206
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        533
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   CARBOHYD        376
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        380
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        405
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        675
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        722
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CONFLICT        223..224
FT                   /note="SV -> KC (in Ref. 3; AW584611)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   748 AA;  80476 MW;  EFB315C7B4CA70D7 CRC64;
     MMKMELRLLV SLIFILCSIS MLAAEENLEH DQINLMTYIV HVKKSENVAS HQSEDLHSWY
     HSFLPQTFPH KERMVFSYRK VASGFAVKLT PEEAKSLQEK GEIVSARPER TLELHTTHTP
     TFLGLKQGQG LWSDDNLGKG VIIGIIDTGI FPLHPSFNDE GMPPPPAKWK GHCEFTGGQV
     CNNKLIGARN LVKSAIQEPP FENFFHGTHT AAEAAGRFIE DASVFGNAKG VAAGMAPNAH
     LAIYKVCNDK IGCTESAILA AMDIAIEDGV DVLSLSLGLG SLPFFEDPIA IGAFAATQNG
     VFVSCSAANS GPGYSTLSNE APWILTVGAS TIDRKIVASA KLGNGEEYEG ETLFQPKDFS
     QQLLPLVYPG SFGYGNQTQN QSLCLPGSLK NIDLSGKVVL CDVGNVSSIV KGQEVLNSGG
     IAMILANSEA LGFSTFAIAH VLPAVEVSYA AGLTIKSYIK STYNPTATLI FKGTIIGDSL
     APSVVYFSSR GPSQESPGIL KPDIIGPGVN ILAAWAVSVD NKIPAFDIVS GTSMSCPHLS
     GIAALIKSSH PDWSPAAIKS AIMTTANTLN LGGIPILDQR LFPADIFATG AGHVNPVKAN
     DPGLVYDIEP EDYVPYLCGL GYSDKEIEVI VQWKVKCSNV KSIPEAQLNY PSFSILLGSD
     SQYYTRTLTN VGFANSTYKV ELEVPLALGM SVNPSEITFT EVNEKVSFSV EFIPQIKENR
     RNHTFGQGSL TWVSDRHAVR IPISVIFK
 
 
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