SC13A_ARATH
ID SC13A_ARATH Reviewed; 302 AA.
AC Q9SRI1; Q8LAS2;
DT 29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 157.
DE RecName: Full=Protein transport protein SEC13 homolog A {ECO:0000305};
DE AltName: Full=SEC13-like protein A {ECO:0000305};
GN Name=SEC13A {ECO:0000303|PubMed:24280388};
GN OrderedLocusNames=At3g01340 {ECO:0000312|Araport:AT3G01340};
GN ORFNames=T22N4.3 {ECO:0000312|EMBL:AAF03492.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND INTERACTION WITH MAG5; SEC31A AND
RP SEC31B.
RX PubMed=24280388; DOI=10.1105/tpc.113.118158;
RA Takagi J., Renna L., Takahashi H., Koumoto Y., Tamura K., Stefano G.,
RA Fukao Y., Kondo M., Nishimura M., Shimada T., Brandizzi F.,
RA Hara-Nishimura I.;
RT "MAIGO5 functions in protein export from Golgi-associated endoplasmic
RT reticulum exit sites in Arabidopsis.";
RL Plant Cell 25:4658-4675(2013).
CC -!- FUNCTION: Required for protein transport from the endoplasmic reticulum
CC to the Golgi apparatus. {ECO:0000305|PubMed:24280388}.
CC -!- SUBUNIT: Interacts with MAG5, SEC31A and SEC31B.
CC {ECO:0000269|PubMed:24280388}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000305|PubMed:24280388}.
CC Endoplasmic reticulum {ECO:0000305|PubMed:24280388}.
CC -!- SIMILARITY: Belongs to the WD repeat SEC13 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC010676; AAF03492.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE73651.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE73652.1; -; Genomic_DNA.
DR EMBL; AF370262; AAK44077.1; -; mRNA.
DR EMBL; AY063079; AAL34253.1; -; mRNA.
DR EMBL; AY087647; AAM65185.1; -; mRNA.
DR RefSeq; NP_001030616.1; NM_001035539.1.
DR RefSeq; NP_186783.1; NM_111000.3.
DR AlphaFoldDB; Q9SRI1; -.
DR SMR; Q9SRI1; -.
DR BioGRID; 6549; 6.
DR IntAct; Q9SRI1; 3.
DR STRING; 3702.AT3G01340.1; -.
DR PaxDb; Q9SRI1; -.
DR PRIDE; Q9SRI1; -.
DR ProMEX; Q9SRI1; -.
DR ProteomicsDB; 226654; -.
DR DNASU; 821216; -.
DR EnsemblPlants; AT3G01340.1; AT3G01340.1; AT3G01340.
DR EnsemblPlants; AT3G01340.2; AT3G01340.2; AT3G01340.
DR GeneID; 821216; -.
DR Gramene; AT3G01340.1; AT3G01340.1; AT3G01340.
DR Gramene; AT3G01340.2; AT3G01340.2; AT3G01340.
DR KEGG; ath:AT3G01340; -.
DR Araport; AT3G01340; -.
DR TAIR; locus:2100267; AT3G01340.
DR eggNOG; KOG1332; Eukaryota.
DR HOGENOM; CLU_032441_0_1_1; -.
DR InParanoid; Q9SRI1; -.
DR OMA; NEWTQSH; -.
DR OrthoDB; 944756at2759; -.
DR PhylomeDB; Q9SRI1; -.
DR PRO; PR:Q9SRI1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SRI1; baseline and differential.
DR Genevisible; Q9SRI1; AT.
DR GO; GO:0030127; C:COPII vesicle coat; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0031080; C:nuclear pore outer ring; IBA:GO_Central.
DR GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
DR GO; GO:0090114; P:COPII-coated vesicle budding; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR037363; Sec13/Seh1_fam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR11024; PTHR11024; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW Protein transport; Reference proteome; Repeat; Transport; WD repeat.
FT CHAIN 1..302
FT /note="Protein transport protein SEC13 homolog A"
FT /id="PRO_0000430538"
FT REPEAT 9..48
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 54..95
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 101..142
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 148..201
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 208..251
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 257..296
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT CONFLICT 246
FT /note="Missing (in Ref. 4; AAM65185)"
FT CONFLICT 271
FT /note="G -> A (in Ref. 4; AAM65185)"
SQ SEQUENCE 302 AA; 32631 MW; 3FCC914E0B19DE31 CRC64;
MPPQKIETGH SDTIHDVVMD YYGKRVATAS SDCTIKITGV SNSGGSQHLA TLTGHRGPVW
QVAWAHPKFG SLLASCSYDG QIILWKEGNQ NQWTQAHVFT DHKVSVNSIA WAPHELGLSL
ACGASDGNIS VFSARADGGW DTTKIDQAHP VGVTSVSWAP ATEPGALVSS GMIDPVYKLA
SGGCDSTVKV WKFSNGSWKM DCFPALNKHT DWVRDVAWAP NLGLPKSTIA SGSEDGKVII
WTIGKEGEQW EGTVLKDFKT PVWRVSWSLT GNLLAVSDGN NNVTVWKESV DGEWEQVTVV
EP