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SC13A_ARATH
ID   SC13A_ARATH             Reviewed;         302 AA.
AC   Q9SRI1; Q8LAS2;
DT   29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 157.
DE   RecName: Full=Protein transport protein SEC13 homolog A {ECO:0000305};
DE   AltName: Full=SEC13-like protein A {ECO:0000305};
GN   Name=SEC13A {ECO:0000303|PubMed:24280388};
GN   OrderedLocusNames=At3g01340 {ECO:0000312|Araport:AT3G01340};
GN   ORFNames=T22N4.3 {ECO:0000312|EMBL:AAF03492.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND INTERACTION WITH MAG5; SEC31A AND
RP   SEC31B.
RX   PubMed=24280388; DOI=10.1105/tpc.113.118158;
RA   Takagi J., Renna L., Takahashi H., Koumoto Y., Tamura K., Stefano G.,
RA   Fukao Y., Kondo M., Nishimura M., Shimada T., Brandizzi F.,
RA   Hara-Nishimura I.;
RT   "MAIGO5 functions in protein export from Golgi-associated endoplasmic
RT   reticulum exit sites in Arabidopsis.";
RL   Plant Cell 25:4658-4675(2013).
CC   -!- FUNCTION: Required for protein transport from the endoplasmic reticulum
CC       to the Golgi apparatus. {ECO:0000305|PubMed:24280388}.
CC   -!- SUBUNIT: Interacts with MAG5, SEC31A and SEC31B.
CC       {ECO:0000269|PubMed:24280388}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000305|PubMed:24280388}.
CC       Endoplasmic reticulum {ECO:0000305|PubMed:24280388}.
CC   -!- SIMILARITY: Belongs to the WD repeat SEC13 family. {ECO:0000305}.
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DR   EMBL; AC010676; AAF03492.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE73651.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE73652.1; -; Genomic_DNA.
DR   EMBL; AF370262; AAK44077.1; -; mRNA.
DR   EMBL; AY063079; AAL34253.1; -; mRNA.
DR   EMBL; AY087647; AAM65185.1; -; mRNA.
DR   RefSeq; NP_001030616.1; NM_001035539.1.
DR   RefSeq; NP_186783.1; NM_111000.3.
DR   AlphaFoldDB; Q9SRI1; -.
DR   SMR; Q9SRI1; -.
DR   BioGRID; 6549; 6.
DR   IntAct; Q9SRI1; 3.
DR   STRING; 3702.AT3G01340.1; -.
DR   PaxDb; Q9SRI1; -.
DR   PRIDE; Q9SRI1; -.
DR   ProMEX; Q9SRI1; -.
DR   ProteomicsDB; 226654; -.
DR   DNASU; 821216; -.
DR   EnsemblPlants; AT3G01340.1; AT3G01340.1; AT3G01340.
DR   EnsemblPlants; AT3G01340.2; AT3G01340.2; AT3G01340.
DR   GeneID; 821216; -.
DR   Gramene; AT3G01340.1; AT3G01340.1; AT3G01340.
DR   Gramene; AT3G01340.2; AT3G01340.2; AT3G01340.
DR   KEGG; ath:AT3G01340; -.
DR   Araport; AT3G01340; -.
DR   TAIR; locus:2100267; AT3G01340.
DR   eggNOG; KOG1332; Eukaryota.
DR   HOGENOM; CLU_032441_0_1_1; -.
DR   InParanoid; Q9SRI1; -.
DR   OMA; NEWTQSH; -.
DR   OrthoDB; 944756at2759; -.
DR   PhylomeDB; Q9SRI1; -.
DR   PRO; PR:Q9SRI1; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9SRI1; baseline and differential.
DR   Genevisible; Q9SRI1; AT.
DR   GO; GO:0030127; C:COPII vesicle coat; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031080; C:nuclear pore outer ring; IBA:GO_Central.
DR   GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
DR   GO; GO:0090114; P:COPII-coated vesicle budding; IBA:GO_Central.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR037363; Sec13/Seh1_fam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR11024; PTHR11024; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW   Protein transport; Reference proteome; Repeat; Transport; WD repeat.
FT   CHAIN           1..302
FT                   /note="Protein transport protein SEC13 homolog A"
FT                   /id="PRO_0000430538"
FT   REPEAT          9..48
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          54..95
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          101..142
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          148..201
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          208..251
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          257..296
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        246
FT                   /note="Missing (in Ref. 4; AAM65185)"
FT   CONFLICT        271
FT                   /note="G -> A (in Ref. 4; AAM65185)"
SQ   SEQUENCE   302 AA;  32631 MW;  3FCC914E0B19DE31 CRC64;
     MPPQKIETGH SDTIHDVVMD YYGKRVATAS SDCTIKITGV SNSGGSQHLA TLTGHRGPVW
     QVAWAHPKFG SLLASCSYDG QIILWKEGNQ NQWTQAHVFT DHKVSVNSIA WAPHELGLSL
     ACGASDGNIS VFSARADGGW DTTKIDQAHP VGVTSVSWAP ATEPGALVSS GMIDPVYKLA
     SGGCDSTVKV WKFSNGSWKM DCFPALNKHT DWVRDVAWAP NLGLPKSTIA SGSEDGKVII
     WTIGKEGEQW EGTVLKDFKT PVWRVSWSLT GNLLAVSDGN NNVTVWKESV DGEWEQVTVV
     EP
 
 
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