SC22A_HUMAN
ID SC22A_HUMAN Reviewed; 307 AA.
AC Q96IW7; B2RE26; Q9Y682;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Vesicle-trafficking protein SEC22a;
DE AltName: Full=SEC22 vesicle-trafficking protein homolog A;
DE AltName: Full=SEC22 vesicle-trafficking protein-like 2;
GN Name=SEC22A; Synonyms=SEC22L2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000312|EMBL:AAD43013.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Umbilical cord blood {ECO:0000312|EMBL:AAD43013.1};
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AAH07122.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix {ECO:0000312|EMBL:AAH07122.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND SER-8, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: May be involved in vesicle transport between the ER and the
CC Golgi complex. {ECO:0000250|UniProtKB:Q642F4}.
CC -!- INTERACTION:
CC Q96IW7; Q86Y34: ADGRG3; NbExp=3; IntAct=EBI-8652744, EBI-17979264;
CC Q96IW7; Q13520: AQP6; NbExp=3; IntAct=EBI-8652744, EBI-13059134;
CC Q96IW7; P07307-3: ASGR2; NbExp=3; IntAct=EBI-8652744, EBI-12808270;
CC Q96IW7; O75787: ATP6AP2; NbExp=3; IntAct=EBI-8652744, EBI-2512037;
CC Q96IW7; Q13323: BIK; NbExp=3; IntAct=EBI-8652744, EBI-700794;
CC Q96IW7; Q12983: BNIP3; NbExp=3; IntAct=EBI-8652744, EBI-749464;
CC Q96IW7; Q8IYJ2-2: C10orf67; NbExp=3; IntAct=EBI-8652744, EBI-13381098;
CC Q96IW7; Q6UWD8: C16orf54; NbExp=3; IntAct=EBI-8652744, EBI-18041102;
CC Q96IW7; Q9BXU9: CALN1; NbExp=3; IntAct=EBI-8652744, EBI-12187137;
CC Q96IW7; Q9UJ71: CD207; NbExp=3; IntAct=EBI-8652744, EBI-2873235;
CC Q96IW7; Q9UGN4: CD300A; NbExp=3; IntAct=EBI-8652744, EBI-10320732;
CC Q96IW7; P09564: CD7; NbExp=3; IntAct=EBI-8652744, EBI-2836587;
CC Q96IW7; P04233-2: CD74; NbExp=3; IntAct=EBI-8652744, EBI-12222807;
CC Q96IW7; Q8N5K1: CISD2; NbExp=3; IntAct=EBI-8652744, EBI-1045797;
CC Q96IW7; Q8IUN9: CLEC10A; NbExp=3; IntAct=EBI-8652744, EBI-2873246;
CC Q96IW7; Q2HXU8-2: CLEC12B; NbExp=3; IntAct=EBI-8652744, EBI-12811991;
CC Q96IW7; Q9UHP7-3: CLEC2D; NbExp=3; IntAct=EBI-8652744, EBI-11749983;
CC Q96IW7; Q9BXN2-6: CLEC7A; NbExp=3; IntAct=EBI-8652744, EBI-11989440;
CC Q96IW7; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-8652744, EBI-6942903;
CC Q96IW7; P49447: CYB561; NbExp=3; IntAct=EBI-8652744, EBI-8646596;
CC Q96IW7; Q53TN4: CYBRD1; NbExp=3; IntAct=EBI-8652744, EBI-8637742;
CC Q96IW7; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-8652744, EBI-742054;
CC Q96IW7; Q9NR28: DIABLO; NbExp=3; IntAct=EBI-8652744, EBI-517508;
CC Q96IW7; Q86UW9: DTX2; NbExp=10; IntAct=EBI-8652744, EBI-740376;
CC Q96IW7; Q92838: EDA; NbExp=7; IntAct=EBI-8652744, EBI-529425;
CC Q96IW7; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-8652744, EBI-18535450;
CC Q96IW7; O75477: ERLIN1; NbExp=6; IntAct=EBI-8652744, EBI-359299;
CC Q96IW7; P60508: ERVFRD-1; NbExp=3; IntAct=EBI-8652744, EBI-17973325;
CC Q96IW7; Q8TBP5: FAM174A; NbExp=3; IntAct=EBI-8652744, EBI-18636064;
CC Q96IW7; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-8652744, EBI-18304435;
CC Q96IW7; Q969F0: FATE1; NbExp=6; IntAct=EBI-8652744, EBI-743099;
CC Q96IW7; Q96LL3: FIMP; NbExp=3; IntAct=EBI-8652744, EBI-12887376;
CC Q96IW7; P21217: FUT3; NbExp=3; IntAct=EBI-8652744, EBI-12839380;
CC Q96IW7; Q05329: GAD2; NbExp=3; IntAct=EBI-8652744, EBI-9304251;
CC Q96IW7; Q6P531: GGT6; NbExp=3; IntAct=EBI-8652744, EBI-2868927;
CC Q96IW7; O95377: GJB5; NbExp=3; IntAct=EBI-8652744, EBI-3909454;
CC Q96IW7; O95452: GJB6; NbExp=3; IntAct=EBI-8652744, EBI-13345609;
CC Q96IW7; O60883: GPR37L1; NbExp=3; IntAct=EBI-8652744, EBI-2927498;
CC Q96IW7; Q96HH9: GRAMD2B; NbExp=3; IntAct=EBI-8652744, EBI-2832937;
CC Q96IW7; Q8TDQ0: HAVCR2; NbExp=3; IntAct=EBI-8652744, EBI-11472922;
CC Q96IW7; Q9UBK5: HCST; NbExp=3; IntAct=EBI-8652744, EBI-2801937;
CC Q96IW7; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-8652744, EBI-1052304;
CC Q96IW7; P32942: ICAM3; NbExp=3; IntAct=EBI-8652744, EBI-725421;
CC Q96IW7; P63252: KCNJ2; NbExp=3; IntAct=EBI-8652744, EBI-703457;
CC Q96IW7; Q96B96: LDAF1; NbExp=3; IntAct=EBI-8652744, EBI-7055862;
CC Q96IW7; Q5T700: LDLRAD1; NbExp=3; IntAct=EBI-8652744, EBI-10173166;
CC Q96IW7; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-8652744, EBI-2820517;
CC Q96IW7; P43657: LPAR6; NbExp=3; IntAct=EBI-8652744, EBI-2876949;
CC Q96IW7; Q8N386: LRRC25; NbExp=3; IntAct=EBI-8652744, EBI-11304917;
CC Q96IW7; Q8N112: LSMEM2; NbExp=3; IntAct=EBI-8652744, EBI-10264855;
CC Q96IW7; Q9GZU1: MCOLN1; NbExp=3; IntAct=EBI-8652744, EBI-721209;
CC Q96IW7; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-8652744, EBI-11956541;
CC Q96IW7; Q99735: MGST2; NbExp=3; IntAct=EBI-8652744, EBI-11324706;
CC Q96IW7; Q9UPX6: MINAR1; NbExp=3; IntAct=EBI-8652744, EBI-11977115;
CC Q96IW7; Q96JA4: MS4A14; NbExp=3; IntAct=EBI-8652744, EBI-12839612;
CC Q96IW7; Q96HJ5: MS4A3; NbExp=3; IntAct=EBI-8652744, EBI-12806656;
CC Q96IW7; Q96JQ5: MS4A4A; NbExp=5; IntAct=EBI-8652744, EBI-12820341;
CC Q96IW7; P21757: MSR1; NbExp=7; IntAct=EBI-8652744, EBI-1776976;
CC Q96IW7; P35372-10: OPRM1; NbExp=3; IntAct=EBI-8652744, EBI-12807478;
CC Q96IW7; Q9H813: PACC1; NbExp=3; IntAct=EBI-8652744, EBI-4319734;
CC Q96IW7; O00623: PEX12; NbExp=3; IntAct=EBI-8652744, EBI-594836;
CC Q96IW7; P35232: PHB; NbExp=3; IntAct=EBI-8652744, EBI-354213;
CC Q96IW7; O14684: PTGES; NbExp=3; IntAct=EBI-8652744, EBI-11161398;
CC Q96IW7; Q8TDF6-2: RASGRP4; NbExp=3; IntAct=EBI-8652744, EBI-12816371;
CC Q96IW7; Q86VR2: RETREG3; NbExp=5; IntAct=EBI-8652744, EBI-10192441;
CC Q96IW7; Q5EBL4-3: RILPL1; NbExp=3; IntAct=EBI-8652744, EBI-12072024;
CC Q96IW7; Q6P5S7: RNASEK; NbExp=3; IntAct=EBI-8652744, EBI-18397230;
CC Q96IW7; P50876: RNF144A; NbExp=3; IntAct=EBI-8652744, EBI-2340657;
CC Q96IW7; Q6ZMZ0: RNF19B; NbExp=3; IntAct=EBI-8652744, EBI-2466594;
CC Q96IW7; Q99942: RNF5; NbExp=3; IntAct=EBI-8652744, EBI-348482;
CC Q96IW7; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-8652744, EBI-3920694;
CC Q96IW7; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-8652744, EBI-17247926;
CC Q96IW7; Q9NX18: SDHAF2; NbExp=3; IntAct=EBI-8652744, EBI-713250;
CC Q96IW7; P11686: SFTPC; NbExp=6; IntAct=EBI-8652744, EBI-10197617;
CC Q96IW7; Q15849: SLC14A2; NbExp=3; IntAct=EBI-8652744, EBI-1573290;
CC Q96IW7; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-8652744, EBI-8644112;
CC Q96IW7; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-8652744, EBI-17295964;
CC Q96IW7; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-8652744, EBI-12898013;
CC Q96IW7; Q9BZL3: SMIM3; NbExp=3; IntAct=EBI-8652744, EBI-741850;
CC Q96IW7; Q9NPE6: SPAG4; NbExp=3; IntAct=EBI-8652744, EBI-10819434;
CC Q96IW7; Q9H169-2: STMN4; NbExp=3; IntAct=EBI-8652744, EBI-20117546;
CC Q96IW7; Q8TAV4: STOML3; NbExp=3; IntAct=EBI-8652744, EBI-12900395;
CC Q96IW7; Q16623: STX1A; NbExp=3; IntAct=EBI-8652744, EBI-712466;
CC Q96IW7; P32856-2: STX2; NbExp=3; IntAct=EBI-8652744, EBI-11956649;
CC Q96IW7; Q12846: STX4; NbExp=6; IntAct=EBI-8652744, EBI-744942;
CC Q96IW7; Q96L08: SUSD3; NbExp=3; IntAct=EBI-8652744, EBI-18194029;
CC Q96IW7; Q8N205: SYNE4; NbExp=3; IntAct=EBI-8652744, EBI-7131783;
CC Q96IW7; Q9UP52: TFR2; NbExp=3; IntAct=EBI-8652744, EBI-3934135;
CC Q96IW7; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-8652744, EBI-12947623;
CC Q96IW7; Q9BVK6: TMED9; NbExp=3; IntAct=EBI-8652744, EBI-1056827;
CC Q96IW7; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-8652744, EBI-2821497;
CC Q96IW7; Q8WUU8: TMEM174; NbExp=3; IntAct=EBI-8652744, EBI-10276729;
CC Q96IW7; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-8652744, EBI-10982110;
CC Q96IW7; Q96B21: TMEM45B; NbExp=3; IntAct=EBI-8652744, EBI-3923061;
CC Q96IW7; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-8652744, EBI-18178701;
CC Q96IW7; Q6P5X7-2: TMEM71; NbExp=3; IntAct=EBI-8652744, EBI-12886878;
CC Q96IW7; Q9BSE2: TMEM79; NbExp=7; IntAct=EBI-8652744, EBI-8649725;
CC Q96IW7; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-8652744, EBI-12345267;
CC Q96IW7; O43557: TNFSF14; NbExp=3; IntAct=EBI-8652744, EBI-524131;
CC Q96IW7; Q96A56: TP53INP1; NbExp=3; IntAct=EBI-8652744, EBI-9986117;
CC Q96IW7; Q6PIZ9: TRAT1; NbExp=3; IntAct=EBI-8652744, EBI-17710254;
CC Q96IW7; Q8IWR1: TRIM59; NbExp=5; IntAct=EBI-8652744, EBI-10262539;
CC Q96IW7; P17643: TYRP1; NbExp=3; IntAct=EBI-8652744, EBI-7900408;
CC Q96IW7; Q5T4F4: ZFYVE27; NbExp=3; IntAct=EBI-8652744, EBI-3892947;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD43013.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF100749; AAD43013.1; ALT_FRAME; mRNA.
DR EMBL; AK315771; BAG38123.1; -; mRNA.
DR EMBL; CH471052; EAW79451.1; -; Genomic_DNA.
DR EMBL; BC007122; AAH07122.1; -; mRNA.
DR CCDS; CCDS3021.1; -.
DR RefSeq; NP_036562.2; NM_012430.4.
DR RefSeq; XP_011510975.1; XM_011512673.2.
DR RefSeq; XP_011510977.1; XM_011512675.2.
DR RefSeq; XP_011510978.1; XM_011512676.2.
DR AlphaFoldDB; Q96IW7; -.
DR SMR; Q96IW7; -.
DR BioGRID; 117937; 119.
DR IntAct; Q96IW7; 104.
DR MINT; Q96IW7; -.
DR STRING; 9606.ENSP00000310521; -.
DR iPTMnet; Q96IW7; -.
DR PhosphoSitePlus; Q96IW7; -.
DR SwissPalm; Q96IW7; -.
DR BioMuta; SEC22A; -.
DR DMDM; 74732111; -.
DR EPD; Q96IW7; -.
DR jPOST; Q96IW7; -.
DR MassIVE; Q96IW7; -.
DR MaxQB; Q96IW7; -.
DR PaxDb; Q96IW7; -.
DR PeptideAtlas; Q96IW7; -.
DR PRIDE; Q96IW7; -.
DR ProteomicsDB; 76864; -.
DR Antibodypedia; 32946; 37 antibodies from 8 providers.
DR DNASU; 26984; -.
DR Ensembl; ENST00000309934.4; ENSP00000310521.4; ENSG00000121542.12.
DR Ensembl; ENST00000492595.6; ENSP00000417972.1; ENSG00000121542.12.
DR GeneID; 26984; -.
DR KEGG; hsa:26984; -.
DR MANE-Select; ENST00000492595.6; ENSP00000417972.1; NM_012430.5; NP_036562.2.
DR UCSC; uc003ege.4; human.
DR CTD; 26984; -.
DR DisGeNET; 26984; -.
DR GeneCards; SEC22A; -.
DR HGNC; HGNC:20260; SEC22A.
DR HPA; ENSG00000121542; Low tissue specificity.
DR MIM; 612442; gene.
DR neXtProt; NX_Q96IW7; -.
DR OpenTargets; ENSG00000121542; -.
DR PharmGKB; PA134921956; -.
DR VEuPathDB; HostDB:ENSG00000121542; -.
DR eggNOG; KOG0862; Eukaryota.
DR GeneTree; ENSGT00940000158470; -.
DR InParanoid; Q96IW7; -.
DR OMA; PYQISVS; -.
DR OrthoDB; 903466at2759; -.
DR PhylomeDB; Q96IW7; -.
DR TreeFam; TF105933; -.
DR PathwayCommons; Q96IW7; -.
DR Reactome; R-HSA-204005; COPII-mediated vesicle transport.
DR SignaLink; Q96IW7; -.
DR BioGRID-ORCS; 26984; 21 hits in 1083 CRISPR screens.
DR ChiTaRS; SEC22A; human.
DR GeneWiki; SEC22A; -.
DR GenomeRNAi; 26984; -.
DR Pharos; Q96IW7; Tdark.
DR PRO; PR:Q96IW7; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q96IW7; protein.
DR Bgee; ENSG00000121542; Expressed in secondary oocyte and 166 other tissues.
DR ExpressionAtlas; Q96IW7; baseline and differential.
DR Genevisible; Q96IW7; HS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:ProtInc.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005484; F:SNAP receptor activity; ISS:UniProtKB.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd14824; Longin; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR027152; Sec22a.
DR InterPro; IPR043546; Sec22a/c.
DR PANTHER; PTHR46258; PTHR46258; 1.
DR PANTHER; PTHR46258:SF3; PTHR46258:SF3; 1.
DR Pfam; PF13774; Longin; 1.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
DR PROSITE; PS50859; LONGIN; 1.
PE 1: Evidence at protein level;
KW Acetylation; Coiled coil; Endoplasmic reticulum; ER-Golgi transport;
KW Membrane; Phosphoprotein; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22814378"
FT CHAIN 2..307
FT /note="Vesicle-trafficking protein SEC22a"
FT /id="PRO_0000253043"
FT TOPO_DOM 2..187
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..226
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..274
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..307
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 8..119
FT /note="Longin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 6
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 8
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT CONFLICT 61
FT /note="N -> K (in Ref. 1; AAD43013)"
FT /evidence="ECO:0000305"
FT CONFLICT 116
FT /note="D -> N (in Ref. 1; AAD43013)"
FT /evidence="ECO:0000305"
FT CONFLICT 295
FT /note="L -> V (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 303..304
FT /note="PD -> SR (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 307 AA; 34948 MW; 227A7F6944EC621F CRC64;
MSMILSASVI RVRDGLPLSA STDYEQSTGM QECRKYFKML SRKLAQLPDR CTLKTGHYNI
NFISSLGVSY MMLCTENYPN VLAFSFLDEL QKEFITTYNM MKTNTAVRPY CFIEFDNFIQ
RTKQRYNNPR SLSTKINLSD MQTEIKLRPP YQISMCELGS ANGVTSAFSV DCKGAGKISS
AHQRLEPATL SGIVGFILSL LCGALNLIRG FHAIESLLQS DGDDFNYIIA FFLGTAACLY
QCYLLVYYTG WRNVKSFLTF GLICLCNMYL YELRNLWQLF FHVTVGAFVT LQIWLRQAQG
KAPDYDV
