ID   SC22A_MACFA             Reviewed;         307 AA.
AC   Q4R866;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Vesicle-trafficking protein SEC22a;
DE   AltName: Full=SEC22 vesicle-trafficking protein homolog A;
GN   Name=SEC22A; ORFNames=QtsA-13287;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1] {ECO:0000312|EMBL:BAE00706.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis {ECO:0000312|EMBL:BAE00706.1};
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
CC   -!- FUNCTION: May be involved in vesicle transport between the ER and the
CC       Golgi complex. {ECO:0000250|UniProtKB:Q642F4}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
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DR   EMBL; AB168592; BAE00706.1; -; mRNA.
DR   RefSeq; NP_001270605.1; NM_001283676.1.
DR   RefSeq; XP_005548022.1; XM_005547965.2.
DR   RefSeq; XP_005548024.1; XM_005547967.2.
DR   RefSeq; XP_015300765.1; XM_015445279.1.
DR   AlphaFoldDB; Q4R866; -.
DR   SMR; Q4R866; -.
DR   STRING; 9541.XP_005548022.1; -.
DR   Ensembl; ENSMFAT00000011937; ENSMFAP00000037686; ENSMFAG00000038056.
DR   GeneID; 101865042; -.
DR   KEGG; mcf:101865042; -.
DR   CTD; 26984; -.
DR   VEuPathDB; HostDB:ENSMFAG00000038056; -.
DR   eggNOG; KOG0862; Eukaryota.
DR   GeneTree; ENSGT00940000158470; -.
DR   OMA; PYQISVS; -.
DR   OrthoDB; 903466at2759; -.
DR   Proteomes; UP000233100; Chromosome 2.
DR   Bgee; ENSMFAG00000038056; Expressed in pituitary gland and 13 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd14824; Longin; 1.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   InterPro; IPR010908; Longin_dom.
DR   InterPro; IPR027152; Sec22a.
DR   InterPro; IPR043546; Sec22a/c.
DR   PANTHER; PTHR46258; PTHR46258; 1.
DR   PANTHER; PTHR46258:SF3; PTHR46258:SF3; 1.
DR   Pfam; PF13774; Longin; 1.
DR   SMART; SM01270; Longin; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
DR   PROSITE; PS50859; LONGIN; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Coiled coil; Endoplasmic reticulum; ER-Golgi transport;
KW   Membrane; Phosphoprotein; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q96IW7"
FT   CHAIN           2..307
FT                   /note="Vesicle-trafficking protein SEC22a"
FT                   /id="PRO_0000253044"
FT   TOPO_DOM        2..187
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        209..226
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        248..253
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        272..274
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        296..307
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          8..119
FT                   /note="Longin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96IW7"
FT   MOD_RES         6
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96IW7"
FT   MOD_RES         8
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96IW7"
SQ   SEQUENCE   307 AA;  34934 MW;  DFD9A554703F2F2B CRC64;
     MSMILSASVI RVRDGLPLSA STDYEQSTGM QECRKYFKML SRKLAQLPDR CTLKTGHYNI
     NFISSLGVSY MMLCTDNYPN VLAFSFLDEL QKEFITTYNM MKTNTAVRPY CFIEFDNFIQ
     RTKQRYNNPR SLSTKINLSD MQTEIKLRPP YQISMCELGS ANGVTSAFSV DCKGAGKISS
     AHQRLEPATL SGIVGFILSL LCGALNLIRG FHAIESLLQS DGDDFNYIIA FFLGTAACLY
     QCYLLVYYTG WRNVKSFLTF GLICLCNMYL YELRNLWQLF FHVTVGAFVT LQIWLRQAQG
     KAPDYDV