SC22A_MOUSE
ID SC22A_MOUSE Reviewed; 307 AA.
AC Q8BH47; Q91Z54;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Vesicle-trafficking protein SEC22a;
DE AltName: Full=SEC22 vesicle-trafficking protein homolog A;
DE AltName: Full=SEC22 vesicle-trafficking protein-like 2;
GN Name=Sec22a {ECO:0000312|MGI:MGI:2447876};
GN Synonyms=Sec22l2 {ECO:0000312|MGI:MGI:2447876};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAC32004.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC32004.1};
RC TISSUE=Cerebellum {ECO:0000312|EMBL:BAC38514.1}, and
RC Retina {ECO:0000312|EMBL:BAC32004.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAH10189.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 62-307.
RC STRAIN=Czech II {ECO:0000312|EMBL:AAH10189.2};
RC TISSUE=Mammary gland {ECO:0000312|EMBL:AAH10189.2};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in vesicle transport between the ER and the
CC Golgi complex. {ECO:0000250|UniProtKB:Q642F4}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH10189.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK044615; BAC32004.1; -; mRNA.
DR EMBL; AK082516; BAC38514.1; -; mRNA.
DR EMBL; BC010189; AAH10189.2; ALT_INIT; mRNA.
DR CCDS; CCDS28138.1; -.
DR RefSeq; NP_598465.2; NM_133704.4.
DR AlphaFoldDB; Q8BH47; -.
DR SMR; Q8BH47; -.
DR STRING; 10090.ENSMUSP00000039568; -.
DR PhosphoSitePlus; Q8BH47; -.
DR MaxQB; Q8BH47; -.
DR PaxDb; Q8BH47; -.
DR PRIDE; Q8BH47; -.
DR ProteomicsDB; 256733; -.
DR Antibodypedia; 32946; 37 antibodies from 8 providers.
DR DNASU; 317717; -.
DR Ensembl; ENSMUST00000043521; ENSMUSP00000039568; ENSMUSG00000034473.
DR GeneID; 317717; -.
DR KEGG; mmu:317717; -.
DR UCSC; uc007zbk.1; mouse.
DR CTD; 26984; -.
DR MGI; MGI:2447876; Sec22a.
DR VEuPathDB; HostDB:ENSMUSG00000034473; -.
DR eggNOG; KOG0862; Eukaryota.
DR GeneTree; ENSGT00940000158470; -.
DR HOGENOM; CLU_054453_0_0_1; -.
DR InParanoid; Q8BH47; -.
DR OMA; PYQISVS; -.
DR OrthoDB; 903466at2759; -.
DR PhylomeDB; Q8BH47; -.
DR TreeFam; TF105933; -.
DR Reactome; R-MMU-204005; COPII-mediated vesicle transport.
DR BioGRID-ORCS; 317717; 8 hits in 74 CRISPR screens.
DR ChiTaRS; Sec22a; mouse.
DR PRO; PR:Q8BH47; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q8BH47; protein.
DR Bgee; ENSMUSG00000034473; Expressed in spermatocyte and 233 other tissues.
DR ExpressionAtlas; Q8BH47; baseline and differential.
DR Genevisible; Q8BH47; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; ISO:MGI.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISO:MGI.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd14824; Longin; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR027152; Sec22a.
DR InterPro; IPR043546; Sec22a/c.
DR PANTHER; PTHR46258; PTHR46258; 1.
DR PANTHER; PTHR46258:SF3; PTHR46258:SF3; 1.
DR Pfam; PF13774; Longin; 1.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
DR PROSITE; PS50859; LONGIN; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Coiled coil; Endoplasmic reticulum; ER-Golgi transport;
KW Membrane; Phosphoprotein; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q96IW7"
FT CHAIN 2..307
FT /note="Vesicle-trafficking protein SEC22a"
FT /id="PRO_0000253045"
FT TOPO_DOM 2..187
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..226
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..274
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..307
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 8..119
FT /note="Longin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:Q96IW7"
FT MOD_RES 6
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96IW7"
FT MOD_RES 8
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96IW7"
SQ SEQUENCE 307 AA; 35025 MW; 4E412E2BE37202B5 CRC64;
MSMILSASVI RVRDGLPLSA STDYEQSTGM QECRKYFKML SRKLAQFPDR CTLKTGRYNI
NFISSLGVSY MMLCSENYPN VLAFSFLDEL QKEFITTYNM MKTNTAVRPY CFIEFDNFIQ
RTKQRYNNPR SLSTKINLSD MQMEIKLRPP YQIPMCELGS ANGVTSAFSV DCKGAGKISS
AHQRLEPATL SGIVAFILSL LCGALNLIRG FHAIESLLQS DGEDLNYIIA FFLGTAACLY
QCYLLVYYTS WRNVKSFLTF GLICLCNMYL YELRNLWQLF FHVTVGAFVT LQIWLRQAQG
KAPDHDV
