SC22A_RAT
ID SC22A_RAT Reviewed; 307 AA.
AC Q642F4; Q62891;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Vesicle-trafficking protein SEC22a;
DE AltName: Full=SEC22 vesicle-trafficking protein homolog A;
DE AltName: Full=SEC22 vesicle-trafficking protein-like 2;
DE Short=rSec22a;
GN Name=Sec22a; Synonyms=Sec22l2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAB03367.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, AND SUBCELLULAR LOCATION.
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAB03367.1};
RC TISSUE=Liver {ECO:0000269|PubMed:8621431};
RX PubMed=8621431; DOI=10.1074/jbc.271.10.5671;
RA Hay J.C., Hirling H., Scheller R.H.;
RT "Mammalian vesicle trafficking proteins of the endoplasmic reticulum and
RT Golgi apparatus.";
RL J. Biol. Chem. 271:5671-5679(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in vesicle transport between the ER and the
CC Golgi complex. {ECO:0000269|PubMed:8621431}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:8621431}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:8621431}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q642F4-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:8621431}; Synonyms=rsec22a
CC {ECO:0000269|PubMed:8621431};
CC IsoId=Q642F4-2; Sequence=VSP_020996;
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
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DR EMBL; U42209; AAB03367.1; -; mRNA.
DR EMBL; BC081746; AAH81746.1; -; mRNA.
DR RefSeq; NP_476488.2; NM_057147.2. [Q642F4-1]
DR RefSeq; XP_006248481.1; XM_006248419.3. [Q642F4-1]
DR RefSeq; XP_006248482.1; XM_006248420.3. [Q642F4-1]
DR RefSeq; XP_008766915.2; XM_008768693.2. [Q642F4-2]
DR AlphaFoldDB; Q642F4; -.
DR SMR; Q642F4; -.
DR STRING; 10116.ENSRNOP00000061258; -.
DR PaxDb; Q642F4; -.
DR PRIDE; Q642F4; -.
DR Ensembl; ENSRNOT00000063795; ENSRNOP00000061258; ENSRNOG00000043069. [Q642F4-1]
DR GeneID; 117513; -.
DR KEGG; rno:117513; -.
DR UCSC; RGD:621659; rat. [Q642F4-1]
DR CTD; 26984; -.
DR RGD; 621659; Sec22a.
DR eggNOG; KOG0862; Eukaryota.
DR GeneTree; ENSGT00940000158470; -.
DR HOGENOM; CLU_054453_0_0_1; -.
DR InParanoid; Q642F4; -.
DR OMA; PYQISVS; -.
DR OrthoDB; 903466at2759; -.
DR PhylomeDB; Q642F4; -.
DR Reactome; R-RNO-204005; COPII-mediated vesicle transport.
DR PRO; PR:Q642F4; -.
DR Proteomes; UP000002494; Chromosome 11.
DR Bgee; ENSRNOG00000043069; Expressed in liver and 19 other tissues.
DR Genevisible; Q642F4; RN.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IDA:RGD.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IDA:RGD.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd14824; Longin; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR027152; Sec22a.
DR InterPro; IPR043546; Sec22a/c.
DR PANTHER; PTHR46258; PTHR46258; 1.
DR PANTHER; PTHR46258:SF3; PTHR46258:SF3; 1.
DR Pfam; PF13774; Longin; 1.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
DR PROSITE; PS50859; LONGIN; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Alternative splicing; Coiled coil; Endoplasmic reticulum;
KW ER-Golgi transport; Membrane; Phosphoprotein; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q96IW7"
FT CHAIN 2..307
FT /note="Vesicle-trafficking protein SEC22a"
FT /id="PRO_0000253046"
FT TOPO_DOM 2..187
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..226
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..274
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..307
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 8..119
FT /note="Longin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:Q96IW7"
FT MOD_RES 6
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96IW7"
FT MOD_RES 8
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96IW7"
FT VAR_SEQ 242..307
FT /note="CYLLVYYTSWRNVKSFLTFGLICLCNMYLYELRNLWQLFFHVTVGAFVTLQI
FT WLRQAQGKAPDHDV -> MICLCLQGRKERT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:8621431"
FT /id="VSP_020996"
SQ SEQUENCE 307 AA; 34902 MW; 6476E49A735794E9 CRC64;
MSMILSASVV RVRDGLPLSA STDCEQSAGV QECRKYFKML SRKLAQFPDR CTLKTGRHNI
NFISSLGVSY MMLCTENYPN VLAFSFLDEL QKEFITTYNM MKTNTAVRPY CFIEFDNFIQ
RTKQRYNNPR SLSTKINLSD MQMEIKLRPP YQIPMCELGS ANGVTSAFSV DCKGAGKISS
AHQRLEPATL SGIVAFILSL LCGALNLIRG FHAIESLLQS DGEDFSYMIA FFLGTAACLY
QCYLLVYYTS WRNVKSFLTF GLICLCNMYL YELRNLWQLF FHVTVGAFVT LQIWLRQAQG
KAPDHDV
