SC22B_CHICK
ID SC22B_CHICK Reviewed; 215 AA.
AC Q5ZJW4;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Vesicle-trafficking protein SEC22b;
DE AltName: Full=SEC22 vesicle-trafficking protein homolog B;
GN Name=SEC22B {ECO:0000250|UniProtKB:O75396}; ORFNames=RCJMB04_15c3;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1] {ECO:0000312|EMBL:CAG31979.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB {ECO:0000312|EMBL:CAG31979.1};
RC TISSUE=Bursa of Fabricius {ECO:0000312|EMBL:CAG31979.1};
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: SNARE involved in targeting and fusion of ER-derived
CC transport vesicles with the Golgi complex as well as Golgi-derived
CC retrograde transport vesicles with the ER.
CC {ECO:0000250|UniProtKB:O75396, ECO:0000250|UniProtKB:Q4KM74}.
CC -!- SUBUNIT: Component of 2 distinct SNARE complexes.
CC {ECO:0000250|UniProtKB:O75396}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q4KM74}; Single-pass type IV membrane protein
CC {ECO:0000250|UniProtKB:Q4KM74}. Endoplasmic reticulum-Golgi
CC intermediate compartment membrane {ECO:0000250|UniProtKB:Q4KM74}. Golgi
CC apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q4KM74}.
CC Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250|UniProtKB:Q4KM74}. Melanosome
CC {ECO:0000250|UniProtKB:O75396}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000255}.
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DR EMBL; AJ720320; CAG31979.1; -; mRNA.
DR RefSeq; NP_001026437.1; NM_001031266.3.
DR AlphaFoldDB; Q5ZJW4; -.
DR SMR; Q5ZJW4; -.
DR STRING; 9031.ENSGALP00000041744; -.
DR PaxDb; Q5ZJW4; -.
DR Ensembl; ENSGALT00000079169; ENSGALP00000051201; ENSGALG00000039704.
DR GeneID; 424377; -.
DR KEGG; gga:424377; -.
DR CTD; 9554; -.
DR VEuPathDB; HostDB:geneid_424377; -.
DR eggNOG; KOG0862; Eukaryota.
DR GeneTree; ENSGT00940000156349; -.
DR HOGENOM; CLU_054453_4_1_1; -.
DR InParanoid; Q5ZJW4; -.
DR OMA; ERSYPRK; -.
DR OrthoDB; 903466at2759; -.
DR PhylomeDB; Q5ZJW4; -.
DR Reactome; R-GGA-204005; COPII-mediated vesicle transport.
DR Reactome; R-GGA-5694530; Cargo concentration in the ER.
DR Reactome; R-GGA-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR PRO; PR:Q5ZJW4; -.
DR Proteomes; UP000000539; Chromosome 8.
DR Bgee; ENSGALG00000039704; Expressed in liver and 14 other tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:1902902; P:negative regulation of autophagosome assembly; IEA:Ensembl.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0048280; P:vesicle fusion with Golgi apparatus; IBA:GO_Central.
DR CDD; cd14824; Longin; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR044565; Sec22.
DR InterPro; IPR001388; Synaptobrevin.
DR InterPro; IPR042855; V_SNARE_CC.
DR PANTHER; PTHR45837; PTHR45837; 1.
DR Pfam; PF13774; Longin; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR PRINTS; PR00219; SYNAPTOBREVN.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
DR PROSITE; PS50859; LONGIN; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW Membrane; Protein transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..215
FT /note="Vesicle-trafficking protein SEC22b"
FT /id="PRO_0000252242"
FT TOPO_DOM 1..194
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 6..119
FT /note="Longin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT DOMAIN 134..194
FT /note="v-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
SQ SEQUENCE 215 AA; 24718 MW; B0ADF3A7CF16C870 CRC64;
MVLLTMIARV ADGLPLAASM QEDEQSGRDL QQYQSQAKQL FRKLNEQSPT RCTLEAGAMA
FHYIIEKGVC YLVLCEAAFP KKLAFAYLED LQSEFDEQHG KKVPTVSRPY SFIEFDTYIQ
KTKKLYIDSR ARRNLGSINT ELQDVQRIMV ANIEEVLQRG EALSALDSKA NNLSSLSKKY
RQDAKYLNMR STYAKLAAVA VFFIMLIVYV RFWWL
