ID   SC22B_XENTR             Reviewed;         215 AA.
AC   Q6P7L4;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Vesicle-trafficking protein SEC22b;
DE   AltName: Full=SEC22 vesicle-trafficking protein homolog B;
DE   AltName: Full=SEC22-like protein 1;
GN   Name=sec22b {ECO:0000250|UniProtKB:O75396};
GN   Synonyms=sec22l1 {ECO:0000312|EMBL:AAH61616.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAH61616.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryonic tail;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: SNARE involved in targeting and fusion of ER-derived
CC       transport vesicles with the Golgi complex as well as Golgi-derived
CC       retrograde transport vesicles with the ER.
CC       {ECO:0000250|UniProtKB:O75396, ECO:0000250|UniProtKB:Q4KM74}.
CC   -!- SUBUNIT: Component of 2 distinct SNARE complexes.
CC       {ECO:0000250|UniProtKB:O75396}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q4KM74}; Single-pass type IV membrane protein
CC       {ECO:0000250|UniProtKB:Q4KM74}. Endoplasmic reticulum-Golgi
CC       intermediate compartment membrane {ECO:0000250|UniProtKB:Q4KM74}. Golgi
CC       apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q4KM74}.
CC       Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000250|UniProtKB:Q4KM74}. Melanosome
CC       {ECO:0000250|UniProtKB:O75396}.
CC   -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC061616; AAH61616.1; -; mRNA.
DR   RefSeq; NP_989156.1; NM_203825.1.
DR   AlphaFoldDB; Q6P7L4; -.
DR   SMR; Q6P7L4; -.
DR   STRING; 8364.ENSXETP00000054708; -.
DR   PaxDb; Q6P7L4; -.
DR   PRIDE; Q6P7L4; -.
DR   DNASU; 394761; -.
DR   Ensembl; ENSXETT00000054708; ENSXETP00000054708; ENSXETG00000025777.
DR   GeneID; 394761; -.
DR   KEGG; xtr:394761; -.
DR   CTD; 9554; -.
DR   Xenbase; XB-GENE-999421; sec22b.
DR   eggNOG; KOG0862; Eukaryota.
DR   HOGENOM; CLU_054453_4_1_1; -.
DR   InParanoid; Q6P7L4; -.
DR   OrthoDB; 903466at2759; -.
DR   Reactome; R-XTR-204005; COPII-mediated vesicle transport.
DR   Reactome; R-XTR-5694530; Cargo concentration in the ER.
DR   Reactome; R-XTR-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000025777; Expressed in neurula embryo and 12 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR   GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0048280; P:vesicle fusion with Golgi apparatus; IBA:GO_Central.
DR   CDD; cd14824; Longin; 1.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   InterPro; IPR010908; Longin_dom.
DR   InterPro; IPR044565; Sec22.
DR   InterPro; IPR042855; V_SNARE_CC.
DR   PANTHER; PTHR45837; PTHR45837; 1.
DR   Pfam; PF13774; Longin; 1.
DR   Pfam; PF00957; Synaptobrevin; 1.
DR   SMART; SM01270; Longin; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
DR   PROSITE; PS50859; LONGIN; 1.
DR   PROSITE; PS50892; V_SNARE; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW   Membrane; Protein transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..215
FT                   /note="Vesicle-trafficking protein SEC22b"
FT                   /id="PRO_0000252245"
FT   TOPO_DOM        1..190
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        214..215
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          6..119
FT                   /note="Longin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT   DOMAIN          134..194
FT                   /note="v-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
SQ   SEQUENCE   215 AA;  24709 MW;  A1EBDF12041ACC60 CRC64;
     MVLLTMIARV ADGLPLAASM QEDEQSGRDL QQYQNQAKQL FRKLNEQSPT RCTLEAGAMT
     FHYLIEKGVC YLVLCEAAFP KKLAFAYLED LFSEFDEQHG KKVPTVSRPY SFIEFDNYIQ
     KTKKSYIDSR ARRNLSSVNT ELQDVQRIMV ANIEEVLLRG EALSALDSKA SNLSTLSKKY
     RQDAKYLNMR STYAKLAAVA VFSVMLIVYI RFWWL