ID   SC22C_BOVIN             Reviewed;         303 AA.
AC   Q2YDJ2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Vesicle-trafficking protein SEC22c;
DE   AltName: Full=SEC22 vesicle-trafficking protein homolog C;
GN   Name=SEC22C;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in vesicle transport between the ER and the
CC       Golgi complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
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DR   EMBL; BC110195; AAI10196.1; -; mRNA.
DR   RefSeq; NP_001040011.1; NM_001046546.2.
DR   RefSeq; XP_010815828.1; XM_010817526.2.
DR   RefSeq; XP_010815830.1; XM_010817528.2.
DR   RefSeq; XP_010815831.1; XM_010817529.2.
DR   RefSeq; XP_010815833.1; XM_010817531.2.
DR   RefSeq; XP_010815834.1; XM_010817532.1.
DR   AlphaFoldDB; Q2YDJ2; -.
DR   SMR; Q2YDJ2; -.
DR   STRING; 9913.ENSBTAP00000008631; -.
DR   PaxDb; Q2YDJ2; -.
DR   PRIDE; Q2YDJ2; -.
DR   Ensembl; ENSBTAT00000008631; ENSBTAP00000008631; ENSBTAG00000006570.
DR   Ensembl; ENSBTAT00000077660; ENSBTAP00000073788; ENSBTAG00000006570.
DR   GeneID; 614905; -.
DR   KEGG; bta:614905; -.
DR   CTD; 9117; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006570; -.
DR   VGNC; VGNC:34409; SEC22C.
DR   eggNOG; KOG0862; Eukaryota.
DR   GeneTree; ENSGT00940000159338; -.
DR   HOGENOM; CLU_054453_0_0_1; -.
DR   InParanoid; Q2YDJ2; -.
DR   OMA; CNIYLYG; -.
DR   OrthoDB; 903466at2759; -.
DR   TreeFam; TF105933; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000006570; Expressed in oocyte and 108 other tissues.
DR   ExpressionAtlas; Q2YDJ2; baseline.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd14824; Longin; 1.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   InterPro; IPR010908; Longin_dom.
DR   InterPro; IPR043546; Sec22a/c.
DR   PANTHER; PTHR46258; PTHR46258; 1.
DR   Pfam; PF13774; Longin; 1.
DR   SMART; SM01270; Longin; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
DR   PROSITE; PS50859; LONGIN; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..303
FT                   /note="Vesicle-trafficking protein SEC22c"
FT                   /id="PRO_0000324160"
FT   TOPO_DOM        1..183
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        205..223
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        245..248
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        270
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..303
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          8..119
FT                   /note="Longin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
SQ   SEQUENCE   303 AA;  34133 MW;  7B6E53E6BAFC2FD7 CRC64;
     MSLILFACVV RVRDGLPLSA STDFYHSQDF LECRRRLKTL ALRLAQYPGR GSAEGCDFSI
     HFSSSRDVAC MAICSLQCPA AMAFCFLETL WWEFTASYDT TCVGLASRPY AFLEFDNVIQ
     KVKWHFNYVS STQMDSSLGK IQEELKFQPP VVLTLEDTDV ANGVMNGHTL MHLEPAPSFR
     MEPVTALGIL SLILNIMCAA LNLIRGIHLA EHSLQVAHEE IGNILAFLIP FVACIFQCYL
     YLFYSPARTM KVVLMLLFIC LGNVYLHGLR NLWQILFHIG VAFLSSHQIL TRQLQDKQSD
     CGV