SC22C_HUMAN
ID SC22C_HUMAN Reviewed; 303 AA.
AC Q9BRL7; O95152; Q68CX3; Q6UW18;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Vesicle-trafficking protein SEC22c;
DE AltName: Full=SEC22 vesicle-trafficking protein homolog C;
DE AltName: Full=SEC22 vesicle-trafficking protein-like 3;
GN Name=SEC22C; Synonyms=SEC22L3; ORFNames=UNQ459/PRO784;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RX PubMed=9501016; DOI=10.1006/bbrc.1998.8194;
RA Tang B.L., Low D.Y., Hong W.;
RT "Hsec22c: a homolog of yeast Sec22p and mammalian rsec22a and msec22b/ERS-
RT 24.";
RL Biochem. Biophys. Res. Commun. 243:885-891(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=B-cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 80-303 (ISOFORM 2).
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: May be involved in vesicle transport between the ER and the
CC Golgi complex. {ECO:0000269|PubMed:9501016}.
CC -!- INTERACTION:
CC Q9BRL7; Q969F0: FATE1; NbExp=6; IntAct=EBI-10297029, EBI-743099;
CC Q9BRL7; P48165: GJA8; NbExp=3; IntAct=EBI-10297029, EBI-17458373;
CC Q9BRL7; Q9H400: LIME1; NbExp=3; IntAct=EBI-10297029, EBI-2830566;
CC Q9BRL7; Q8IWY8-3: ZSCAN29; NbExp=3; IntAct=EBI-10297029, EBI-14188237;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:9501016}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:9501016}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9BRL7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BRL7-2; Sequence=VSP_032163, VSP_032164;
CC Name=3;
CC IsoId=Q9BRL7-3; Sequence=VSP_032161, VSP_032162;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:9501016}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
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DR EMBL; AF039568; AAD02171.1; -; mRNA.
DR EMBL; AK292856; BAF85545.1; -; mRNA.
DR EMBL; AY359041; AAQ89400.1; -; mRNA.
DR EMBL; CH471055; EAW64653.1; -; Genomic_DNA.
DR EMBL; CH471055; EAW64654.1; -; Genomic_DNA.
DR EMBL; BC006178; AAH06178.1; -; mRNA.
DR EMBL; BC018437; AAH18437.1; -; mRNA.
DR EMBL; CR749670; CAH18461.1; -; mRNA.
DR CCDS; CCDS2699.1; -. [Q9BRL7-2]
DR CCDS; CCDS2700.1; -. [Q9BRL7-1]
DR CCDS; CCDS56246.1; -. [Q9BRL7-3]
DR PIR; JE0157; JE0157.
DR RefSeq; NP_001188501.1; NM_001201572.1. [Q9BRL7-2]
DR RefSeq; NP_001188513.1; NM_001201584.1. [Q9BRL7-3]
DR RefSeq; NP_004197.1; NM_004206.3. [Q9BRL7-2]
DR RefSeq; NP_116752.1; NM_032970.3. [Q9BRL7-1]
DR RefSeq; XP_011532514.1; XM_011534212.1. [Q9BRL7-1]
DR AlphaFoldDB; Q9BRL7; -.
DR SMR; Q9BRL7; -.
DR BioGRID; 114565; 11.
DR IntAct; Q9BRL7; 10.
DR STRING; 9606.ENSP00000264454; -.
DR iPTMnet; Q9BRL7; -.
DR PhosphoSitePlus; Q9BRL7; -.
DR BioMuta; SEC22C; -.
DR DMDM; 74732899; -.
DR MassIVE; Q9BRL7; -.
DR PaxDb; Q9BRL7; -.
DR PeptideAtlas; Q9BRL7; -.
DR PRIDE; Q9BRL7; -.
DR ProteomicsDB; 78787; -. [Q9BRL7-1]
DR ProteomicsDB; 78788; -. [Q9BRL7-2]
DR ProteomicsDB; 78789; -. [Q9BRL7-3]
DR Antibodypedia; 29226; 40 antibodies from 16 providers.
DR DNASU; 9117; -.
DR Ensembl; ENST00000264454.8; ENSP00000264454.3; ENSG00000093183.14. [Q9BRL7-1]
DR Ensembl; ENST00000273156.11; ENSP00000273156.7; ENSG00000093183.14. [Q9BRL7-2]
DR Ensembl; ENST00000417572.5; ENSP00000407564.1; ENSG00000093183.14. [Q9BRL7-2]
DR Ensembl; ENST00000423701.6; ENSP00000414576.2; ENSG00000093183.14. [Q9BRL7-3]
DR GeneID; 9117; -.
DR KEGG; hsa:9117; -.
DR MANE-Select; ENST00000264454.8; ENSP00000264454.3; NM_032970.4; NP_116752.1.
DR UCSC; uc003clh.4; human. [Q9BRL7-1]
DR CTD; 9117; -.
DR GeneCards; SEC22C; -.
DR HGNC; HGNC:16828; SEC22C.
DR HPA; ENSG00000093183; Low tissue specificity.
DR MIM; 604028; gene.
DR neXtProt; NX_Q9BRL7; -.
DR OpenTargets; ENSG00000093183; -.
DR PharmGKB; PA134952972; -.
DR VEuPathDB; HostDB:ENSG00000093183; -.
DR eggNOG; KOG0862; Eukaryota.
DR GeneTree; ENSGT00940000159338; -.
DR InParanoid; Q9BRL7; -.
DR OMA; CNIYLYG; -.
DR OrthoDB; 903466at2759; -.
DR PhylomeDB; Q9BRL7; -.
DR TreeFam; TF105933; -.
DR PathwayCommons; Q9BRL7; -.
DR Reactome; R-HSA-204005; COPII-mediated vesicle transport.
DR SignaLink; Q9BRL7; -.
DR BioGRID-ORCS; 9117; 11 hits in 1074 CRISPR screens.
DR ChiTaRS; SEC22C; human.
DR GenomeRNAi; 9117; -.
DR Pharos; Q9BRL7; Tdark.
DR PRO; PR:Q9BRL7; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9BRL7; protein.
DR Bgee; ENSG00000093183; Expressed in parotid gland and 181 other tissues.
DR ExpressionAtlas; Q9BRL7; baseline and differential.
DR Genevisible; Q9BRL7; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; TAS:ProtInc.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd14824; Longin; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR043546; Sec22a/c.
DR PANTHER; PTHR46258; PTHR46258; 1.
DR Pfam; PF13774; Longin; 1.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
DR PROSITE; PS50859; LONGIN; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Endoplasmic reticulum; ER-Golgi transport; Membrane;
KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..303
FT /note="Vesicle-trafficking protein SEC22c"
FT /id="PRO_0000324161"
FT TOPO_DOM 1..183
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..223
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 245..248
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..303
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 8..119
FT /note="Longin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT VAR_SEQ 216..228
FT /note="VAHEEIGNILAFL -> DPRSWFCWLDQTS (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_032161"
FT VAR_SEQ 229..303
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_032162"
FT VAR_SEQ 238..250
FT /note="CYLYLFYSPARTM -> DPRSWFCWLDQTS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005, ECO:0000303|PubMed:9501016"
FT /id="VSP_032163"
FT VAR_SEQ 251..303
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005, ECO:0000303|PubMed:9501016"
FT /id="VSP_032164"
SQ SEQUENCE 303 AA; 34269 MW; 24F908848A8A9625 CRC64;
MSVIFFACVV RVRDGLPLSA STDFYHTQDF LEWRRRLKSL ALRLAQYPGR GSAEGCDFSI
HFSSFGDVAC MAICSCQCPA AMAFCFLETL WWEFTASYDT TCIGLASRPY AFLEFDSIIQ
KVKWHFNYVS SSQMECSLEK IQEELKLQPP AVLTLEDTDV ANGVMNGHTP MHLEPAPNFR
MEPVTALGIL SLILNIMCAA LNLIRGVHLA EHSLQVAHEE IGNILAFLVP FVACIFQCYL
YLFYSPARTM KVVLMLLFIC LGNMYLHGLR NLWQILFHIG VAFLSSYQIL TRQLQEKQSD
CGV
