SC22C_MOUSE
ID SC22C_MOUSE Reviewed; 303 AA.
AC Q8BXT9; Q8BMH4; Q8C0R8;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Vesicle-trafficking protein SEC22c;
DE AltName: Full=SEC22 vesicle trafficking protein-like 3;
DE AltName: Full=SEC22 vesicle-trafficking protein homolog C;
GN Name=Sec22c; Synonyms=Sec22l3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Forelimb, Retina, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in vesicle transport between the ER and the
CC Golgi complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
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DR EMBL; AK029985; BAC26717.1; -; mRNA.
DR EMBL; AK031125; BAC27266.1; -; mRNA.
DR EMBL; AK044249; BAC31840.1; -; mRNA.
DR EMBL; BC046289; AAH46289.1; -; mRNA.
DR CCDS; CCDS23634.1; -.
DR RefSeq; NP_001158034.1; NM_001164562.1.
DR RefSeq; NP_848792.2; NM_178677.4.
DR RefSeq; XP_006512105.1; XM_006512042.3.
DR RefSeq; XP_006512106.1; XM_006512043.3.
DR AlphaFoldDB; Q8BXT9; -.
DR SMR; Q8BXT9; -.
DR STRING; 10090.ENSMUSP00000107185; -.
DR iPTMnet; Q8BXT9; -.
DR PhosphoSitePlus; Q8BXT9; -.
DR EPD; Q8BXT9; -.
DR PaxDb; Q8BXT9; -.
DR PRIDE; Q8BXT9; -.
DR ProteomicsDB; 255342; -.
DR Antibodypedia; 29226; 40 antibodies from 16 providers.
DR DNASU; 215474; -.
DR Ensembl; ENSMUST00000078547; ENSMUSP00000077628; ENSMUSG00000061536.
DR Ensembl; ENSMUST00000111560; ENSMUSP00000107185; ENSMUSG00000061536.
DR GeneID; 215474; -.
DR KEGG; mmu:215474; -.
DR UCSC; uc009sdm.2; mouse.
DR CTD; 9117; -.
DR MGI; MGI:2447871; Sec22c.
DR VEuPathDB; HostDB:ENSMUSG00000061536; -.
DR eggNOG; KOG0862; Eukaryota.
DR GeneTree; ENSGT00940000159338; -.
DR HOGENOM; CLU_054453_0_0_1; -.
DR InParanoid; Q8BXT9; -.
DR OMA; CNIYLYG; -.
DR OrthoDB; 903466at2759; -.
DR PhylomeDB; Q8BXT9; -.
DR TreeFam; TF105933; -.
DR Reactome; R-MMU-204005; COPII-mediated vesicle transport.
DR BioGRID-ORCS; 215474; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Sec22c; mouse.
DR PRO; PR:Q8BXT9; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8BXT9; protein.
DR Bgee; ENSMUSG00000061536; Expressed in granulocyte and 197 other tissues.
DR ExpressionAtlas; Q8BXT9; baseline and differential.
DR Genevisible; Q8BXT9; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd14824; Longin; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR043546; Sec22a/c.
DR PANTHER; PTHR46258; PTHR46258; 1.
DR Pfam; PF13774; Longin; 1.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
DR PROSITE; PS50859; LONGIN; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..303
FT /note="Vesicle-trafficking protein SEC22c"
FT /id="PRO_0000324162"
FT TOPO_DOM 1..183
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..223
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 245..248
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..303
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 8..119
FT /note="Longin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT CONFLICT 8
FT /note="S -> N (in Ref. 1; BAC27266)"
FT /evidence="ECO:0000305"
FT CONFLICT 14
FT /note="D -> E (in Ref. 1; BAC26717)"
FT /evidence="ECO:0000305"
FT CONFLICT 49
FT /note="G -> A (in Ref. 1; BAC26717)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 303 AA; 33913 MW; AFD6E5D731C0C90C CRC64;
MSMILFASIV RVRDGLPLSA STDFYYAQEF LECRRQLKTL AQRLARHPGR GCAESCDFLI
YFSSSGDVAC MAICSRQCPA AMAFCFLEAL WWDFIASYDT TCVGLASRPY AFLEFDSVIQ
KTKWHFNHMS SSQMKSGLEK IQEELEFQPP AVLSLEDTDV ANGMLNGHTP VHSEPAPNLR
MKPVTALGVL SLVLNIMCAA LNLIRGVHLA EHSLQVAQEE VGNILAFFIP SVACIVQCYL
YLFYSPARTL KVLLMLASIC LGNAYLHGLR NTWQILFHVG VAFLSSYQIL TRQLQERQSD
YGV
