SC24C_ARATH
ID SC24C_ARATH Reviewed; 1096 AA.
AC Q9M291; A0A1I9LQT4; F4J1Y1;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 3.
DT 25-MAY-2022, entry version 136.
DE RecName: Full=Protein transport protein Sec24-like CEF;
GN Name=CEF; OrderedLocusNames=At3g44340; ORFNames=T22K7_20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia; TISSUE=Seed;
RX PubMed=11053466; DOI=10.1093/jexbot/51.351.1761;
RA Belles-Boix E., Babiychuk E., Van Montagu M., Inze D., Kushnir S.;
RT "CEF, a sec24 homologue of Arabidopsis thaliana, enhances the survival of
RT yeast under oxidative stress conditions.";
RL J. Exp. Bot. 51:1761-1762(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Component of the COPII coat, that covers ER-derived vesicles
CC involved in transport from the endoplasmic reticulum to the Golgi
CC apparatus. COPII is composed of at least five proteins: the SEC23/24
CC complex, the SEC13/31 complex, and the protein SAR1. Acts in the
CC cytoplasm to promote the transport of secretory, plasma membrane, and
CC vacuolar proteins from the endoplasmic reticulum to the Golgi complex
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:O95486}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:O95486}. Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:O95486}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:O95486}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9M291-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB86912.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AJ251579; CAC16574.1; -; mRNA.
DR EMBL; AL138641; CAB86912.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE77893.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM64942.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM64944.1; -; Genomic_DNA.
DR PIR; T47424; T47424.
DR RefSeq; NP_001326943.1; NM_001339129.1. [Q9M291-1]
DR RefSeq; NP_001326945.1; NM_001339130.1. [Q9M291-1]
DR RefSeq; NP_566869.1; NM_114302.3. [Q9M291-1]
DR AlphaFoldDB; Q9M291; -.
DR SMR; Q9M291; -.
DR BioGRID; 8879; 7.
DR STRING; 3702.AT3G44340.1; -.
DR iPTMnet; Q9M291; -.
DR PaxDb; Q9M291; -.
DR PRIDE; Q9M291; -.
DR ProteomicsDB; 232935; -. [Q9M291-1]
DR EnsemblPlants; AT3G44340.1; AT3G44340.1; AT3G44340. [Q9M291-1]
DR EnsemblPlants; AT3G44340.3; AT3G44340.3; AT3G44340. [Q9M291-1]
DR EnsemblPlants; AT3G44340.4; AT3G44340.4; AT3G44340. [Q9M291-1]
DR GeneID; 823559; -.
DR Gramene; AT3G44340.1; AT3G44340.1; AT3G44340. [Q9M291-1]
DR Gramene; AT3G44340.3; AT3G44340.3; AT3G44340. [Q9M291-1]
DR Gramene; AT3G44340.4; AT3G44340.4; AT3G44340. [Q9M291-1]
DR KEGG; ath:AT3G44340; -.
DR Araport; AT3G44340; -.
DR TAIR; locus:2100202; AT3G44340.
DR eggNOG; KOG1984; Eukaryota.
DR HOGENOM; CLU_004589_1_1_1; -.
DR InParanoid; Q9M291; -.
DR OMA; NSMMPGP; -.
DR OrthoDB; 330236at2759; -.
DR PRO; PR:Q9M291; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M291; baseline and differential.
DR Genevisible; Q9M291; AT.
DR GO; GO:0030127; C:COPII vesicle coat; IBA:GO_Central.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR GO; GO:0090110; P:COPII-coated vesicle cargo loading; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEP:TAIR.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 3.40.20.10; -; 1.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR SUPFAM; SSF81811; SSF81811; 1.
DR SUPFAM; SSF82754; SSF82754; 1.
DR SUPFAM; SSF82919; SSF82919; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Endoplasmic reticulum; ER-Golgi transport;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..1096
FT /note="Protein transport protein Sec24-like CEF"
FT /id="PRO_0000205160"
FT REGION 1..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..458
FT /note="Zinc finger-like"
FT COMPBIAS 10..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..66
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..126
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..195
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..232
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..307
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 76
FT /note="Q -> QQ (in Ref. 1; CAC16574)"
FT /evidence="ECO:0000305"
FT CONFLICT 219
FT /note="P -> T (in Ref. 1; CAC16574)"
FT /evidence="ECO:0000305"
FT CONFLICT 277
FT /note="P -> A (in Ref. 1; CAC16574)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1096 AA; 117691 MW; 3F9E7F738C03AD07 CRC64;
MAAPVPPGAY RPNNNQQNSG GPPNFVPGSQ GNPNSLAANM QNLNINRPPP PMPGSGPRPS
PPFGQSPQSF PQQQQQQPRP SPMARPGPPP PAAMARPGGP PQVSQPGGFP PVGRPVAPPS
NQPPFGGRPS TGPLVGGGSS FPQPGGFPAS GPPGGVPSGP PSGARPIGFG SPPPMGPGMS
MPPPSGMPGG PLSNGPPPSG MHGGHLSNGP PPSGMPGGPL SNGPPPPMMG PGAFPRGSQF
TSGPMMAPPP PYGQPPNAGP FTGNSPLSSP PAHSIPPPTN FPGVPYGRPP MPGGFPYGAP
PQQLPSAPGT PGSIYGMGPM QNQSMTSVSS PSKIDLNQIP RPGSSSSPIV YETRVENKAN
PPPPTTVDYI TRDTGNSSPR YMRCTINQIP CTVDLLSTSG MQLALIVQPM ALSHPSEEPI
QVVDFGESGP VRCSRCKGYV NPFMKFIDQG RKFICNLCGY TDETPRDYQC NLGPDGRRRD
ADERPELCRG TVDFVATKEY MVRDPMPAVY FFLIDVSMNA IQTGATAAAC SAIQQVLSDL
PEGPRTFVGI ATFDSTIHFY NLKRALQQPL MLIVPDVQDV YTPLETDVIV QLSECRQHLE
ILLESIPTMF QESKSPESAF GAAVKAAFLA MKSTGGKLMV FQSVLPSVGI GALSSREADG
RANASAGEKE AHKLLQPADK TLRTMAIEFA EYQVCVDLFI TTQAYVDMAS ISEIPRTTGG
QVYCYYPFSA LSDPPKLYND LRWNITRPQG FEAVMRVRCS QGIQVQEYSG NFCKRIPTDI
DLPAIDCDKA IMVTLKHDDK LQDGAECGFQ CALLYTTISG ERRIRVLNLS IPCTNMLSNL
FRSADLDSQF ACMLKQAANE IPSKALPLVK EQATNDCITI LHSYRKFCAT VTSTGQLILP
EALKLLPLYT LALTKGVGLR MDGRIDDRSF WINHVSSLST PLAIPLVYPR MIAVHDLDAN
DNEENVVPCP IPLQSEHLSD EGVYFLENGE DGLIYIGESV NSDILQKLFN VRSAAELPSQ
YVLQKYDNQL SKKFNDVVNE IRRQRSSYLR IKLCKKGDPA GNMLFQSYMV EDRGSGGASY
VDFLVSVHRQ IQHKLN
