SC31A_ARATH
ID SC31A_ARATH Reviewed; 969 AA.
AC F4ICD9; Q9M9V2;
DT 29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Protein transport protein SEC31 homolog A {ECO:0000305};
DE AltName: Full=SEC31-like protein A {ECO:0000305};
GN Name=SEC31A {ECO:0000303|PubMed:24280388};
GN OrderedLocusNames=At1g18830 {ECO:0000312|Araport:AT1G18830};
GN ORFNames=F6A14.8 {ECO:0000312|EMBL:AAF27099.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AEE29767.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP INTERACTION WITH MAG5; SEC13A AND SEC13B.
RX PubMed=24280388; DOI=10.1105/tpc.113.118158;
RA Takagi J., Renna L., Takahashi H., Koumoto Y., Tamura K., Stefano G.,
RA Fukao Y., Kondo M., Nishimura M., Shimada T., Brandizzi F.,
RA Hara-Nishimura I.;
RT "MAIGO5 functions in protein export from Golgi-associated endoplasmic
RT reticulum exit sites in Arabidopsis.";
RL Plant Cell 25:4658-4675(2013).
CC -!- FUNCTION: Required for protein transport from the endoplasmic reticulum
CC to the Golgi apparatus. {ECO:0000305|PubMed:24280388}.
CC -!- SUBUNIT: Interacts with MAG5, SEC13A and SEC13B.
CC {ECO:0000269|PubMed:24280388}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000305|PubMed:24280388}.
CC Endoplasmic reticulum {ECO:0000305|PubMed:24280388}.
CC -!- SIMILARITY: Belongs to the WD repeat SEC31 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF27099.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC011809; AAF27099.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29767.1; -; Genomic_DNA.
DR PIR; B86322; B86322.
DR RefSeq; NP_173317.2; NM_101740.3.
DR AlphaFoldDB; F4ICD9; -.
DR SMR; F4ICD9; -.
DR BioGRID; 23703; 5.
DR STRING; 3702.AT1G18830.1; -.
DR PaxDb; F4ICD9; -.
DR ProteomicsDB; 232908; -.
DR EnsemblPlants; AT1G18830.1; AT1G18830.1; AT1G18830.
DR GeneID; 838464; -.
DR Gramene; AT1G18830.1; AT1G18830.1; AT1G18830.
DR KEGG; ath:AT1G18830; -.
DR Araport; AT1G18830; -.
DR TAIR; locus:2034990; AT1G18830.
DR eggNOG; KOG0307; Eukaryota.
DR HOGENOM; CLU_003033_0_0_1; -.
DR InParanoid; F4ICD9; -.
DR OMA; HMASTEW; -.
DR OrthoDB; 100998at2759; -.
DR PRO; PR:F4ICD9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4ICD9; baseline and differential.
DR Genevisible; F4ICD9; AT.
DR GO; GO:0030127; C:COPII vesicle coat; IBA:GO_Central.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
DR GO; GO:0090110; P:COPII-coated vesicle cargo loading; IBA:GO_Central.
DR GO; GO:0007029; P:endoplasmic reticulum organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR024298; ACE1_Sec16_Sec31.
DR InterPro; IPR040251; SEC31-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13923; PTHR13923; 1.
DR Pfam; PF12931; Sec16_C; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW Protein transport; Reference proteome; Repeat; Transport; WD repeat.
FT CHAIN 1..969
FT /note="Protein transport protein SEC31 homolog A"
FT /id="PRO_0000430540"
FT REPEAT 5..45
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 62..105
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 113..153
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 161..201
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 203..246
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 250..290
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 293..333
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REPEAT 510..550
FT /note="WD 8"
FT /evidence="ECO:0000255"
FT REPEAT 601..642
FT /note="WD 9"
FT /evidence="ECO:0000255"
FT REGION 457..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 722..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 969 AA; 106593 MW; 08EA6025A8BE1AB4 CRC64;
MDCIKSIGRS AFVAIAPESP FIAAGTMAGA VDLSFSSSAN LEIFELDFQS NDRELKLVGQ
CQSSERFNRL AWGSYGSGSD GLIAGGLVDG NIGLWNPISS ESGEIAHVRD LSKHKGPVRG
LEFNVKSPNQ LASGADDGTV CIWDLANPSK PSHYLKGTGS YMQSEISSLS WNKGFQHVLA
STSHNGTTVI WDVNNEKIIT DLKTTVRCSV LQWDPDHFNQ ILVASDEDSS PNVKLLDIRY
LQSPVRTFVG HQRGVIAMEW CPSDSLYLLT CGKDNRTICW NTKTGKIVAE LPTGQNWNFD
VHWYPKMPGV ISASSVDGKI GIYNLEGCSS YGTENQQHFL FHLLDADPLT APKWWKRPAG
ASFGFGGKLI SFNKNLPEAS EVFLHSLATE KSLVNRISKF EAALENGEKT SLRGLCEKKT
EEAESEEEKE TWGLLKIMLE EDGNAKTKLR SHLGFSLPSE ENDQTANEPH ATCSSTNVEE
TQKVPEPEGE EEESSDPTFD DAIQRSLIVG DYKEAVAQCF SANKMADALV IAHVGGTELW
ESTRDKYIRM SNAPYMKVVS AMMNNDLMTY LHTRQPKSWK ETLALICTFA EGDEWISLCD
ALASNLMAAG FTLAATLCYI CAGNVDKTVD IWSMSLEKQS AGKSYAECVQ DLMEKTLVLA
LTTCNKRVSA SLRKLFESYA EILASQGLIA TAMKFLKLLE SGDFSPELSI LRDRISLYAE
PEAANTSAST NTQPKISNPY QEKSFTPAPL SNAQPSRSIT FFPLNPPREL KNADQYQQPT
MDYHSFNRSA GPAYNAPPGP GSYRSIHSQV GPYINSKIPQ TVAPPVRPMT PTHQVAVQPE
PVAPPPTVQT ADTSNVPAHQ KPIVASLTRL FKETFEPLRG YSRDTPAKKR EAEDNCSRKL
GALFSKLNNG DISKNAAEKL TQLCQALDKR DFGAALKIQG LMTSTEWDEC SSWLPTLKKM
IVTGRQNVR
