ID   SC52_SHEEP              Reviewed;         160 AA.
AC   P49929;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Cathelin-related peptide SC5;
DE   AltName: Full=Antibacterial peptide SMAP-29;
DE   AltName: Full=Myeloid antibacterial peptide MAP-29;
DE   Flags: Precursor;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RX   PubMed=8549789; DOI=10.1016/0014-5793(95)01390-3;
RA   Mahoney M.M., Lee A.Y., Brezinski-Caliguri D.J., Huttner K.M.;
RT   "Molecular analysis of the sheep cathelin family reveals a novel
RT   antimicrobial peptide.";
RL   FEBS Lett. 377:519-522(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RX   PubMed=7498547; DOI=10.1016/0014-5793(95)01285-3;
RA   Bagella L., Scocchi M., Zanetti M.;
RT   "cDNA sequences of three sheep myeloid cathelicidins.";
RL   FEBS Lett. 376:225-228(1995).
CC   -!- FUNCTION: Broad spectrum bactericidal agent.
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       Temperature dependence:
CC         Thermostable.;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cathelicidin family. {ECO:0000305}.
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DR   EMBL; X92758; CAA63413.1; -; mRNA.
DR   EMBL; L46854; AAA85470.1; -; mRNA.
DR   PIR; S68228; S68228.
DR   PIR; S68412; S68412.
DR   RefSeq; NP_001009406.1; NM_001009406.1.
DR   AlphaFoldDB; P49929; -.
DR   BMRB; P49929; -.
DR   SMR; P49929; -.
DR   STRING; 9940.ENSOARP00000002274; -.
DR   GeneID; 443424; -.
DR   KEGG; oas:443424; -.
DR   CTD; 443424; -.
DR   eggNOG; ENOG502SAES; Eukaryota.
DR   OrthoDB; 1534863at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008219; P:cell death; IMP:AgBase.
DR   GO; GO:0019835; P:cytolysis; IMP:AgBase.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:AgBase.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IMP:AgBase.
DR   InterPro; IPR001894; Cathelicidin-like.
DR   InterPro; IPR018216; Cathelicidin_CS.
DR   InterPro; IPR046350; Cystatin_sf.
DR   PANTHER; PTHR10206; PTHR10206; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00946; CATHELICIDINS_1; 1.
DR   PROSITE; PS00947; CATHELICIDINS_2; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Disulfide bond; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   PROPEP          30..131
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004760"
FT   PEPTIDE         132..160
FT                   /note="Cathelin-related peptide SC5"
FT                   /id="PRO_0000004761"
FT   DISULFID        86..97
FT                   /evidence="ECO:0000250"
FT   DISULFID        108..125
FT                   /evidence="ECO:0000250"
FT   CONFLICT        28
FT                   /note="S -> R (in Ref. 2; AAA85470)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   160 AA;  17742 MW;  4FB98A09355BB51F CRC64;
     METQRASLSL GRRSLWLLLL GLVLASASAQ ALSYREAVLR AVDQLNEKSS EANLYRLLEL
     DPPPKQDDEN SNIPKPVSFR VKETVCPRTS QQPAEQCDFK ENGLLKECVG TVTLDQVGNN
     FDITCAEPQS VRGLRRLGRK IAHGVKKYGP TVLRIIRIAG