SC5A3_BOVIN
ID SC5A3_BOVIN Reviewed; 718 AA.
AC P53793;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Sodium/myo-inositol cotransporter;
DE Short=Na(+)/myo-inositol cotransporter;
DE AltName: Full=Sodium/myo-inositol transporter 1;
DE Short=SMIT1;
DE AltName: Full=Solute carrier family 5 member 3;
GN Name=SLC5A3; Synonyms=SMIT;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Mallee J.J., Parrella T., Kwon H.M., Berry G.T.;
RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Prevents intracellular accumulation of high concentrations of
CC myo-inositol (an osmolyte) that result in impairment of cellular
CC function.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000305}.
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DR EMBL; U41338; AAA93188.1; -; Genomic_DNA.
DR RefSeq; NP_777032.1; NM_174607.1.
DR AlphaFoldDB; P53793; -.
DR SMR; P53793; -.
DR PRIDE; P53793; -.
DR GeneID; 282362; -.
DR KEGG; bta:282362; -.
DR CTD; 6526; -.
DR InParanoid; P53793; -.
DR OrthoDB; 243316at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005412; F:glucose:sodium symporter activity; IBA:GO_Central.
DR GO; GO:0006020; P:inositol metabolic process; IBA:GO_Central.
DR GO; GO:0015798; P:myo-inositol transport; IBA:GO_Central.
DR CDD; cd11491; SLC5sbd_SMIT; 1.
DR Gene3D; 1.20.1730.10; -; 1.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR InterPro; IPR018212; Na/solute_symporter_CS.
DR InterPro; IPR042731; SMIT.
DR Pfam; PF00474; SSF; 1.
DR TIGRFAMs; TIGR00813; sss; 1.
DR PROSITE; PS00456; NA_SOLUT_SYMP_1; 1.
DR PROSITE; PS00457; NA_SOLUT_SYMP_2; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; Ion transport; Membrane; Phosphoprotein;
KW Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..718
FT /note="Sodium/myo-inositol cotransporter"
FT /id="PRO_0000105379"
FT TOPO_DOM 1..9
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..38
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..86
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..123
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..157
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..186
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..303
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..353
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 377..406
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 431..443
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 444..462
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 463..510
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 511..532
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 533..695
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 696..716
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 717..718
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT SITE 24
FT /note="Implicated in sodium coupling"
FT /evidence="ECO:0000250"
FT SITE 285
FT /note="Implicated in sodium coupling"
FT /evidence="ECO:0000250"
FT MOD_RES 594
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P53794"
FT MOD_RES 632
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P53794"
FT CARBOHYD 232
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 718 AA; 79674 MW; 206BE25FA385111D CRC64;
MRAVLETADI AIVALYFILV MCIGFFAMWK SNRSTVSGYF LAGRSMTWVA IGASLFVSNI
GSEHFIGLAG SGAASGFAVG AWEFNALLLL QLLGWVFIPI YIRSGVYTMP EYLSKRFGGH
RIQVYFAALS LILYIFTKLS VDLYSGALFI QESMGWNLYV SVILLIGMTA LLTVTGGLVA
VIYTDTLQAL LMIVGALTLM VISMMEIGGF EEVKRRYMLA SPNVTSILLT YNLSNTNSCN
VHPKKDALKM LRNPTDEDVP WPGFILGQTP ASVWYWCADQ VIVQRVLAAK NIAHAKGSTL
MAGFLKLLPM FIIVVPGMIS RILFADDIAC INPEHCMQVC GSRAGCSNIA YPRLVMKLVP
VGLRGLMMAV MIAALMSDLD SIFNSASTIF TLDVYKLIRK SASSRELMIV GRIFVAFMVV
ISIAWVPIIV EMQGGQMYLY IQEVADYLTP PVAALFLLAI FWKRCNEQGA FYGGMAGFIL
VVVRLTLAFA YRAPECDQPD NRPVFIKDIH YMYVATALFW ITGLITVIVS LLTPPPTKEQ
IRTTTFWSKK SLVVKESCSP KDEPYKMQEK SILRCSENSE VINHVIPNGK SEDSIKGLQP
EDVNLLVTCR EEGNPVASLG HSEAETPVDA YSNGQAALMG EKERKKEAED GSRYWKFIDW
FCGFKSKSLS KRSLRDLMEE EAVCLQMLEE PPQVKVILNI GLFGVCSLGI FMFVYFSL
