SC5A5_RAT
ID SC5A5_RAT Reviewed; 618 AA.
AC Q63008;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 128.
DE RecName: Full=Sodium/iodide cotransporter;
DE Short=Na(+)/I(-) cotransporter;
DE AltName: Full=Sodium-iodide symporter;
DE Short=Na(+)/I(-) symporter;
DE AltName: Full=Solute carrier family 5 member 5;
GN Name=Slc5a5; Synonyms=Nis;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Thyroid;
RX PubMed=8559252; DOI=10.1038/379458a0;
RA Dai G., Levy O., Carrasco N.;
RT "Cloning and characterization of the thyroid iodide transporter.";
RL Nature 379:458-460(1996).
CC -!- FUNCTION: Mediates iodide uptake in the thyroid gland.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000305}.
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DR EMBL; U60282; AAB03338.1; -; mRNA.
DR PIR; S68513; S68513.
DR RefSeq; NP_443215.2; NM_052983.2.
DR AlphaFoldDB; Q63008; -.
DR SMR; Q63008; -.
DR STRING; 10116.ENSRNOP00000025577; -.
DR BindingDB; Q63008; -.
DR ChEMBL; CHEMBL2331047; -.
DR GlyGen; Q63008; 2 sites.
DR iPTMnet; Q63008; -.
DR PhosphoSitePlus; Q63008; -.
DR PaxDb; Q63008; -.
DR GeneID; 114613; -.
DR KEGG; rno:114613; -.
DR UCSC; RGD:69267; rat.
DR CTD; 6528; -.
DR RGD; 69267; Slc5a5.
DR eggNOG; KOG2349; Eukaryota.
DR InParanoid; Q63008; -.
DR OrthoDB; 1180002at2759; -.
DR PhylomeDB; Q63008; -.
DR Reactome; R-RNO-209968; Thyroxine biosynthesis.
DR Reactome; R-RNO-428643; Organic anion transporters.
DR PRO; PR:Q63008; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; TAS:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; IDA:ARUK-UCL.
DR GO; GO:0015111; F:iodide transmembrane transporter activity; IMP:ARUK-UCL.
DR GO; GO:0008507; F:sodium:iodide symporter activity; IDA:RGD.
DR GO; GO:0015293; F:symporter activity; ISO:RGD.
DR GO; GO:0071320; P:cellular response to cAMP; ISO:RGD.
DR GO; GO:0071371; P:cellular response to gonadotropin stimulus; ISO:RGD.
DR GO; GO:1904200; P:iodide transmembrane transport; IMP:ARUK-UCL.
DR GO; GO:0015705; P:iodide transport; IDA:RGD.
DR GO; GO:0006814; P:sodium ion transport; IDA:RGD.
DR GO; GO:0006590; P:thyroid hormone generation; TAS:RGD.
DR CDD; cd11503; SLC5sbd_NIS; 1.
DR Gene3D; 1.20.1730.10; -; 1.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR InterPro; IPR018212; Na/solute_symporter_CS.
DR InterPro; IPR035689; SLC5A5.
DR Pfam; PF00474; SSF; 1.
DR TIGRFAMs; TIGR00813; sss; 1.
DR PROSITE; PS00456; NA_SOLUT_SYMP_1; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome;
KW Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..618
FT /note="Sodium/iodide cotransporter"
FT /id="PRO_0000105385"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..53
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..88
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..163
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..186
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..241
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..286
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..326
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 348..391
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 413..416
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 438..444
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 466..520
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 521..541
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 542..618
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 587..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 551
FT /note="Phosphoserine; by PKA"
FT /evidence="ECO:0000255"
FT CARBOHYD 485
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 497
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 618 AA; 65196 MW; 91EFAA6752B4F4B2 CRC64;
MEGAEAGARA TFGAWDYGVF ATMLLVSTGI GLWVGLARGG QRSADDFFTG GRQLAAVPVG
LSLAASFMSA VQVLGVPAEA ARYGLKFLWM CAGQLLNSLL TAFLFLPIFY RLGLTSTYQY
LELRFSRAVR LCGTLQYLVA TMLYTGIVIY APALILNQVT GLDIWASLLS TGIICTLYTT
VGGMKAVVWT DVFQVVVMLV GFWVILARGV ILLGGPRNVL SLAQNHSRIN LMDFDPDPRS
RYTFWTFIVG GTLVWLSMYG VNQAQVQRYV ACHTEGKAKL ALLVNQLGLF LIVASAACCG
IVMFVYYKDC DPLLTGRISA PDQYMPLLVL DIFEDLPGVP GLFLACAYSG TLSTASTSIN
AMAAVTVEDL IKPRMPGLAP RKLVFISKGL SFIYGSACLT VAALSSLLGG GVLQGSFTVM
GVISGPLLGA FTLGMLLPAC NTPGVLSGLA AGLAVSLWVA VGATLYPPGE QTMGVLPTSA
AGCTNDSVLL GPPGATNASN GIPSSGMDTG RPALADTFYA ISYLYYGALG TLTTMLCGAL
ISYLTGPTKR SSLGPGLLWW DLARQTASVA PKEDTATLEE SLVKGPEDIP AVTKKPPGLK
PGAETHPLYL GHDVETNL
