SC5A6_RABIT
ID SC5A6_RABIT Reviewed; 636 AA.
AC Q9XT77;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Sodium-dependent multivitamin transporter;
DE Short=Na(+)-dependent multivitamin transporter;
DE AltName: Full=Solute carrier family 5 member 6;
GN Name=SLC5A6; Synonyms=SMVT;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Intestine;
RX PubMed=10334869; DOI=10.1006/abbi.1999.1213;
RA Prasad P.D., Wang H., Huang W., Fei Y.-J., Leibach F.H., Devoe L.D.,
RA Ganapathy V.;
RT "Molecular and functional characterization of the intestinal Na+-dependent
RT multivitamin transporter.";
RL Arch. Biochem. Biophys. 366:95-106(1999).
CC -!- FUNCTION: Sodium-dependent multivitamin transporter that transports
CC pantothenate, biotin and lipoate (By similarity). Required for biotin
CC and pantothenate uptake in the instestine (By similarity). Plays a role
CC in the maintenance of intestinal mucosa integrity, by providing the gut
CC mucosa with biotin (By similarity). May play a role in the transport of
CC biotin and pantothenate into the brain across the blood-brain barrier
CC (By similarity). May also be involved in the sodium-dependent transport
CC of iodide ions (By similarity). {ECO:0000250|UniProtKB:Q5U4D8,
CC ECO:0000250|UniProtKB:Q9Y289}.
CC -!- SUBUNIT: Interacts with PDZD11. {ECO:0000250|UniProtKB:Q9Y289}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9Y289};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000305}.
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DR EMBL; AF080067; AAD37480.1; -; mRNA.
DR RefSeq; NP_001076106.1; NM_001082637.1.
DR AlphaFoldDB; Q9XT77; -.
DR SMR; Q9XT77; -.
DR STRING; 9986.ENSOCUP00000014587; -.
DR Ensembl; ENSOCUT00000016978; ENSOCUP00000014587; ENSOCUG00000016976.
DR GeneID; 100009326; -.
DR KEGG; ocu:100009326; -.
DR CTD; 8884; -.
DR eggNOG; KOG2349; Eukaryota.
DR GeneTree; ENSGT00940000155731; -.
DR HOGENOM; CLU_018808_11_1_1; -.
DR InParanoid; Q9XT77; -.
DR OMA; YVFIHFI; -.
DR OrthoDB; 327628at2759; -.
DR TreeFam; TF316728; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000016976; Expressed in adult mammalian kidney and 16 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0015225; F:biotin transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0090482; F:vitamin transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:1905135; P:biotin import across plasma membrane; ISS:UniProtKB.
DR GO; GO:1904200; P:iodide transmembrane transport; ISS:UniProtKB.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1730.10; -; 1.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR InterPro; IPR018212; Na/solute_symporter_CS.
DR Pfam; PF00474; SSF; 1.
DR TIGRFAMs; TIGR00813; sss; 1.
DR PROSITE; PS00456; NA_SOLUT_SYMP_1; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 2: Evidence at transcript level;
KW Biotin; Cell membrane; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..636
FT /note="Sodium-dependent multivitamin transporter"
FT /id="PRO_0000105388"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..424
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 528..548
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 606..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 489
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 498
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 636 AA; 68730 MW; C65A7DAA7C5EBD2F CRC64;
MSVGETTSAP PTPAPDSDVI TSTFSLVDYV VFSLLLVFSL AIGLYHACRG WGKHTVGQLL
LADRRMGCLP VALSLLATFQ SAVAILGVPS EIYRFGTQYW FLGCCYFLGL LIPAHVFIPV
FYRLHLTSAY EYLELRFNKV VRICGTVTFI FQMVIYMGVV LYAPSLALNA VTGFDLWLSV
LTLGIVCTIY TALGGLKAVI WTDVFQTLVM FLGQLAVIIV GSAKVGGLGR VWDVASQHGL
ISGIELDPDP FVRHTFWTLA FGGVFMMLSL YGVNQAQVQR YLSSRTEKAA VLSCYAVFPC
QQVALSMGCL IGLVMFAYYQ EYPMSTQQSQ AASDQFVLYF VMDLLKGLPG LPGLFVACLF
SGSLSTISSA FNSLATVTME DLIRPWFPEC SEAQAIMLSR SLAFGYGLLC LGMAYISSQM
GPVLQAAISI FGMVGGPLLG LFCLGMFFPC ANPPGAIVGL LAGLIMAFWI GIGSIVTSMG
SGLAPSPPNG SSFSLPSNLT IATVTTLMPS TSLSKPTGLQ RLYSLSYLWY SAHNSTTVIV
VGLIVSLLTG GMRGRPPNPR TIYPVLPKLL ALLPLSWQKR LHCTSHCQDL PVDTELFPEK
MRNGALRASG DKEPMTEASP VHQGTSPTFI LHETSL
