SC5A6_RAT
ID SC5A6_RAT Reviewed; 634 AA.
AC O70247;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Sodium-dependent multivitamin transporter;
DE Short=Na(+)-dependent multivitamin transporter;
DE AltName: Full=Solute carrier family 5 member 6;
GN Name=Slc5a6; Synonyms=Smvt;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Placenta;
RX PubMed=9516450; DOI=10.1074/jbc.273.13.7501;
RA Prasad P.D., Wang H., Kekuda R., Fujita T., Fei Y.-J., Devoe L.D.,
RA Leibach F.H., Ganapathy V.;
RT "Cloning and functional expression of a cDNA encoding a mammalian sodium-
RT dependent vitamin transporter mediating the uptake of pantothenate, biotin,
RT and lipoate.";
RL J. Biol. Chem. 273:7501-7506(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney, and Small intestine;
RA Kumar C.K., Chatterjee N.S., Rubin S.A., Said H.M.;
RT "Cloning and characterization of rat kidney sodium dependent multivitamin
RT transporter.";
RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=12620923; DOI=10.1152/ajprenal.00364.2002;
RA Nabokina S.M., Subramanian V.S., Said H.M.;
RT "Comparative analysis of ontogenic changes in renal and intestinal biotin
RT transport in the rat.";
RL Am. J. Physiol. 284:F737-F742(2003).
CC -!- FUNCTION: Sodium-dependent multivitamin transporter that transports
CC pantothenate, biotin and lipoate (By similarity). Required for biotin
CC and pantothenate uptake in the instestine (By similarity). Plays a role
CC in the maintenance of intestinal mucosa integrity, by providing the gut
CC mucosa with biotin (By similarity). May play a role in the transport of
CC biotin and pantothenate into the brain across the blood-brain barrier
CC (By similarity). May also be involved in the sodium-dependent transport
CC of iodide ions (By similarity). {ECO:0000250|UniProtKB:Q5U4D8,
CC ECO:0000250|UniProtKB:Q9Y289}.
CC -!- SUBUNIT: Interacts with PDZD11. {ECO:0000250|UniProtKB:Q9Y289}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9Y289};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in the jejunum (at protein level)
CC (PubMed:12620923). Expressed in lung, skeletal muscle, heart, brain,
CC kidney, intestine, liver, and placenta (PubMed:9516450,
CC PubMed:12620923). {ECO:0000269|PubMed:12620923,
CC ECO:0000269|PubMed:9516450}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the jejunum in 13-14 days old animals
CC (at protein level) (PubMed:12620923). Expressed in the kidney in 13-14
CC days old animals (PubMed:12620923). {ECO:0000269|PubMed:12620923}.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000305}.
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DR EMBL; AF026554; AAC12270.1; -; mRNA.
DR EMBL; AF081205; AAC64061.1; -; mRNA.
DR EMBL; AF081204; AAC64060.1; -; mRNA.
DR RefSeq; NP_570102.1; NM_130746.1.
DR AlphaFoldDB; O70247; -.
DR SMR; O70247; -.
DR STRING; 10116.ENSRNOP00000009042; -.
DR ChEMBL; CHEMBL2176793; -.
DR TCDB; 2.A.21.5.2; the solute:sodium symporter (sss) family.
DR GlyGen; O70247; 2 sites.
DR PhosphoSitePlus; O70247; -.
DR PaxDb; O70247; -.
DR Ensembl; ENSRNOT00000082623; ENSRNOP00000075361; ENSRNOG00000057628.
DR GeneID; 170551; -.
DR KEGG; rno:170551; -.
DR CTD; 8884; -.
DR RGD; 69648; Slc5a6.
DR eggNOG; KOG2349; Eukaryota.
DR GeneTree; ENSGT00940000155731; -.
DR HOGENOM; CLU_018808_11_1_1; -.
DR InParanoid; O70247; -.
DR OMA; YVFIHFI; -.
DR OrthoDB; 327628at2759; -.
DR PhylomeDB; O70247; -.
DR TreeFam; TF316728; -.
DR Reactome; R-RNO-196780; Biotin transport and metabolism.
DR Reactome; R-RNO-199220; Vitamin B5 (pantothenate) metabolism.
DR Reactome; R-RNO-425397; Transport of vitamins, nucleosides, and related molecules.
DR PRO; PR:O70247; -.
DR Proteomes; UP000002494; Chromosome 6.
DR Bgee; ENSRNOG00000057628; Expressed in kidney and 20 other tissues.
DR ExpressionAtlas; O70247; baseline and differential.
DR Genevisible; O70247; RN.
DR GO; GO:0031526; C:brush border membrane; IDA:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0012506; C:vesicle membrane; IDA:RGD.
DR GO; GO:0015225; F:biotin transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015233; F:pantothenate transmembrane transporter activity; ISO:RGD.
DR GO; GO:0008523; F:sodium-dependent multivitamin transmembrane transporter activity; IDA:RGD.
DR GO; GO:0015293; F:symporter activity; IBA:GO_Central.
DR GO; GO:0090482; F:vitamin transmembrane transporter activity; ISO:RGD.
DR GO; GO:1905135; P:biotin import across plasma membrane; ISS:UniProtKB.
DR GO; GO:0015878; P:biotin transport; IDA:RGD.
DR GO; GO:1904200; P:iodide transmembrane transport; ISS:UniProtKB.
DR GO; GO:0015887; P:pantothenate transmembrane transport; IDA:RGD.
DR GO; GO:0006814; P:sodium ion transport; IBA:GO_Central.
DR GO; GO:0150104; P:transport across blood-brain barrier; ISO:RGD.
DR Gene3D; 1.20.1730.10; -; 1.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR InterPro; IPR018212; Na/solute_symporter_CS.
DR Pfam; PF00474; SSF; 1.
DR TIGRFAMs; TIGR00813; sss; 1.
DR PROSITE; PS00456; NA_SOLUT_SYMP_1; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 1: Evidence at protein level;
KW Biotin; Cell membrane; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..634
FT /note="Sodium-dependent multivitamin transporter"
FT /id="PRO_0000105389"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 526..546
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 488
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 497
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 634 AA; 68642 MW; 902F60978831BEFC CRC64;
MTVASTAAPS YTTSDTNRVI STFSVVDYVV FGLLLVLSLV IGLYHACRGW GRHTVGELLM
ADRKMGCLPV ALSLLATFQS AVAILGGPAE IYRFGTQYWF LGCSYFLGLL IPAHIFIPVF
YRLHLTSAYE YLELRFNKAV RICGTVTFIF QMVVYMGVAL YAPSLALNAV TGFDLWLSVL
ALGIVCNIYT ALGGLKAVIW TDVFQTLIMF LGQLVVIIVG AAKVGGLGHV WAVASQHGLI
SGIELDPDPF VRHTFWTLAF GGVFMMLSLY GVNQAQVQRY LSSHSEKAAV LSCYAVFPCQ
QVALCMSCLI GLVMFAYYKK YSMSPQQEQA APDQLVLYFV MDLLKDMPGL PGLFVACLFS
GSLSTISSAF NSLATVTMED LIQPWFPQLT ETRAIMLSRS LAFAYGLVCL GMAYVSSHLG
SVLQAALSIF GMVGGPLLGL FCLGMFFPCA NPLGAIVGLL TGLTMAFWIG IGSIVSRMSS
AAASPPLNGS SSFLPSNLTV ATVTTLMPST LSKPTGLQQF YSLSYLWYSA HNSTTVIAVG
LIVSLLTGGM RGRSLNPGTI YPVLPKLLAL LPLSCQKRLC WRSHNQDIPV VTNLFPEKMG
NGALQDSRDK ERMAEDGLVH QPCSPTYIVQ ETSL
