SC5A9_HUMAN
ID SC5A9_HUMAN Reviewed; 681 AA.
AC Q2M3M2; B3KY87; B7ZL45; B7ZL47; E9PAK4; E9PJ08; Q5TET3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Sodium/glucose cotransporter 4;
DE Short=Na(+)/glucose cotransporter 4;
DE Short=hSGLT4;
DE AltName: Full=Solute carrier family 5 member 9;
GN Name=SLC5A9; Synonyms=SGLT4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), FUNCTION, TISSUE
RP SPECIFICITY, AND VARIANT MET-269.
RC TISSUE=Intestine;
RX PubMed=15607332; DOI=10.1016/j.lfs.2004.10.016;
RA Tazawa S., Yamato T., Fujikura H., Hiratochi M., Itoh F., Tomae M.,
RA Takemura Y., Maruyama H., Sugiyama T., Wakamatsu A., Isogai T., Isaji M.;
RT "SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential
RT transporter for mannose, 1,5-anhydro-D-glucitol, and fructose.";
RL Life Sci. 76:1039-1050(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT MET-269.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), AND VARIANTS
RP ILE-124 AND MET-269.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604 AND SER-605, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: Involved in sodium-dependent transport of D-mannose, D-
CC glucose and D-fructose. {ECO:0000269|PubMed:15607332}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q2M3M2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2M3M2-2; Sequence=VSP_044577;
CC Name=3;
CC IsoId=Q2M3M2-3; Sequence=VSP_057168;
CC -!- TISSUE SPECIFICITY: Expressed in the small intestine, kidney and liver.
CC {ECO:0000269|PubMed:15607332}.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000305}.
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DR EMBL; AK131200; BAG54749.1; -; mRNA.
DR EMBL; AL109659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471059; EAX06857.1; -; Genomic_DNA.
DR EMBL; BC104857; AAI04858.1; -; mRNA.
DR EMBL; BC104863; AAI04864.1; -; mRNA.
DR EMBL; BC143570; AAI43571.1; -; mRNA.
DR EMBL; BC143572; AAI43573.1; -; mRNA.
DR CCDS; CCDS30709.2; -. [Q2M3M2-1]
DR CCDS; CCDS44136.1; -. [Q2M3M2-2]
DR RefSeq; NP_001011547.2; NM_001011547.2. [Q2M3M2-1]
DR RefSeq; NP_001128653.1; NM_001135181.1. [Q2M3M2-2]
DR AlphaFoldDB; Q2M3M2; -.
DR SMR; Q2M3M2; -.
DR BioGRID; 128290; 3.
DR IntAct; Q2M3M2; 1.
DR STRING; 9606.ENSP00000236495; -.
DR DrugCentral; Q2M3M2; -.
DR TCDB; 2.A.21.3.17; the solute:sodium symporter (sss) family.
DR GlyGen; Q2M3M2; 2 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q2M3M2; -.
DR PhosphoSitePlus; Q2M3M2; -.
DR BioMuta; SLC5A9; -.
DR DMDM; 189046189; -.
DR jPOST; Q2M3M2; -.
DR MassIVE; Q2M3M2; -.
DR PaxDb; Q2M3M2; -.
DR PeptideAtlas; Q2M3M2; -.
DR PRIDE; Q2M3M2; -.
DR ProteomicsDB; 19032; -.
DR ProteomicsDB; 20981; -.
DR ProteomicsDB; 61379; -. [Q2M3M2-1]
DR Antibodypedia; 32891; 172 antibodies from 24 providers.
DR DNASU; 200010; -.
DR Ensembl; ENST00000236495.9; ENSP00000236495.5; ENSG00000117834.13. [Q2M3M2-2]
DR Ensembl; ENST00000438567.7; ENSP00000401730.2; ENSG00000117834.13. [Q2M3M2-1]
DR Ensembl; ENST00000533824.5; ENSP00000431900.1; ENSG00000117834.13. [Q2M3M2-3]
DR GeneID; 200010; -.
DR KEGG; hsa:200010; -.
DR MANE-Select; ENST00000438567.7; ENSP00000401730.2; NM_001011547.3; NP_001011547.2.
DR UCSC; uc001crn.3; human. [Q2M3M2-1]
DR CTD; 200010; -.
DR DisGeNET; 200010; -.
DR GeneCards; SLC5A9; -.
DR HGNC; HGNC:22146; SLC5A9.
DR HPA; ENSG00000117834; Tissue enriched (intestine).
DR neXtProt; NX_Q2M3M2; -.
DR OpenTargets; ENSG00000117834; -.
DR PharmGKB; PA134949681; -.
DR VEuPathDB; HostDB:ENSG00000117834; -.
DR eggNOG; KOG2349; Eukaryota.
DR GeneTree; ENSGT00940000157546; -.
DR HOGENOM; CLU_018808_9_2_1; -.
DR InParanoid; Q2M3M2; -.
DR OMA; MFFVVMP; -.
DR OrthoDB; 243316at2759; -.
DR PhylomeDB; Q2M3M2; -.
DR TreeFam; TF352855; -.
DR PathwayCommons; Q2M3M2; -.
DR Reactome; R-HSA-189200; Cellular hexose transport.
DR BioGRID-ORCS; 200010; 14 hits in 1063 CRISPR screens.
DR GenomeRNAi; 200010; -.
DR Pharos; Q2M3M2; Tbio.
DR PRO; PR:Q2M3M2; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q2M3M2; protein.
DR Bgee; ENSG00000117834; Expressed in ileal mucosa and 111 other tissues.
DR ExpressionAtlas; Q2M3M2; baseline and differential.
DR Genevisible; Q2M3M2; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005412; F:glucose:sodium symporter activity; IBA:GO_Central.
DR GO; GO:0005362; F:low-affinity glucose:sodium symporter activity; TAS:Reactome.
DR GO; GO:0008645; P:hexose transmembrane transport; TAS:Reactome.
DR GO; GO:0006814; P:sodium ion transport; IBA:GO_Central.
DR Gene3D; 1.20.1730.10; -; 1.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR InterPro; IPR018212; Na/solute_symporter_CS.
DR Pfam; PF00474; SSF; 1.
DR TIGRFAMs; TIGR00813; sss; 1.
DR PROSITE; PS00456; NA_SOLUT_SYMP_1; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Ion transport; Membrane;
KW Phosphoprotein; Reference proteome; Sodium; Sodium transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..681
FT /note="Sodium/glucose cotransporter 4"
FT /id="PRO_0000333805"
FT TOPO_DOM 1..36
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..114
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..157
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..190
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..217
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 239..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..317
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 339..383
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..406
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 407..427
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 449..459
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 481..487
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 509..530
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 531..551
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 552..660
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 661..681
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 579..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 604
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 605
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT CARBOHYD 251
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 113
FT /note="N -> NMRKSRSGGDRGIHPRSHGRTGVRSQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_044577"
FT VAR_SEQ 113
FT /note="N -> NMRKSRSGGDRGIHPRSHGRTG (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_057168"
FT VARIANT 124
FT /note="V -> I (in dbSNP:rs141515954)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_068963"
FT VARIANT 152
FT /note="V -> M (in dbSNP:rs212989)"
FT /id="VAR_043166"
FT VARIANT 207
FT /note="M -> T (in dbSNP:rs12047252)"
FT /id="VAR_043167"
FT VARIANT 269
FT /note="I -> M (in dbSNP:rs212991)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:15607332, ECO:0000269|Ref.3"
FT /id="VAR_043168"
SQ SEQUENCE 681 AA; 74073 MW; 618D27DC590EE826 CRC64;
MSKELAAMGP GASGDGVRTE TAPHIALDSR VGLHAYDISV VVIYFVFVIA VGIWSSIRAS
RGTIGGYFLA GRSMSWWPIG ASLMSSNVGS GLFIGLAGTG AAGGLAVGGF EWNATWLLLA
LGWVFVPVYI AAGVVTMPQY LKKRFGGQRI QVYMSVLSLI LYIFTKISTD IFSGALFIQM
ALGWNLYLST GILLVVTAVY TIAGGLMAVI YTDALQTVIM VGGALVLMFL GFQDVGWYPG
LEQRYRQAIP NVTVPNTTCH LPRPDAFHIL RDPVSGDIPW PGLIFGLTVL ATWCWCTDQV
IVQRSLSAKS LSHAKGGSVL GGYLKILPMF FIVMPGMISR ALFPDEVGCV DPDVCQRICG
ARVGCSNIAY PKLVMALMPV GLRGLMIAVI MAALMSSLTS IFNSSSTLFT IDVWQRFRRK
STEQELMVVG RVFVVFLVVI SILWIPIIQS SNSGQLFDYI QAVTSYLAPP ITALFLLAIF
CKRVTEPGAF WGLVFGLGVG LLRMILEFSY PAPACGEVDR RPAVLKDFHY LYFAILLCGL
TAIVIVIVSL CTTPIPEEQL TRLTWWTRNC PLSELEKEAH ESTPEISERP AGECPAGGGA
AENSSLGQEQ PEAPSRSWGK LLWSWFCGLS GTPEQALSPA EKAALEQKLT SIEEEPLWRH
VCNINAVLLL AINIFLWGYF A
