SC5A9_MOUSE
ID SC5A9_MOUSE Reviewed; 685 AA.
AC Q8VDT1; Q8BGU9; Q8BZW1;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 3.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Sodium/glucose cotransporter 4;
DE Short=Na(+)/glucose cotransporter 4;
DE Short=mSGLT4;
DE AltName: Full=Solute carrier family 5 member 9;
GN Name=Slc5a9; Synonyms=Sglt4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Colon, Embryo, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in sodium-dependent transport of D-mannose, D-
CC glucose and D-fructose. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000305}.
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DR EMBL; AK029158; BAC26332.1; -; mRNA.
DR EMBL; AK033425; BAC28283.1; -; mRNA.
DR EMBL; AK050696; BAC34386.1; -; mRNA.
DR EMBL; BC021357; AAH21357.2; -; mRNA.
DR CCDS; CCDS18474.1; -.
DR RefSeq; NP_663526.3; NM_145551.4.
DR RefSeq; XP_006503063.1; XM_006503000.2.
DR AlphaFoldDB; Q8VDT1; -.
DR SMR; Q8VDT1; -.
DR STRING; 10090.ENSMUSP00000099782; -.
DR GlyGen; Q8VDT1; 1 site.
DR iPTMnet; Q8VDT1; -.
DR PhosphoSitePlus; Q8VDT1; -.
DR jPOST; Q8VDT1; -.
DR PaxDb; Q8VDT1; -.
DR PRIDE; Q8VDT1; -.
DR ProteomicsDB; 256606; -.
DR Antibodypedia; 32891; 172 antibodies from 24 providers.
DR DNASU; 230612; -.
DR Ensembl; ENSMUST00000102719; ENSMUSP00000099780; ENSMUSG00000028544.
DR Ensembl; ENSMUST00000102720; ENSMUSP00000099781; ENSMUSG00000028544.
DR Ensembl; ENSMUST00000102721; ENSMUSP00000099782; ENSMUSG00000028544.
DR GeneID; 230612; -.
DR KEGG; mmu:230612; -.
DR UCSC; uc008udj.3; mouse.
DR CTD; 200010; -.
DR MGI; MGI:2140201; Slc5a9.
DR VEuPathDB; HostDB:ENSMUSG00000028544; -.
DR eggNOG; KOG2349; Eukaryota.
DR GeneTree; ENSGT00940000157546; -.
DR HOGENOM; CLU_018808_9_2_1; -.
DR InParanoid; Q8VDT1; -.
DR OMA; MFFVVMP; -.
DR OrthoDB; 243316at2759; -.
DR PhylomeDB; Q8VDT1; -.
DR TreeFam; TF352855; -.
DR Reactome; R-MMU-189200; Cellular hexose transport.
DR BioGRID-ORCS; 230612; 1 hit in 70 CRISPR screens.
DR ChiTaRS; Slc5a9; mouse.
DR PRO; PR:Q8VDT1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8VDT1; protein.
DR Bgee; ENSMUSG00000028544; Expressed in optic fissure and 71 other tissues.
DR ExpressionAtlas; Q8VDT1; baseline and differential.
DR Genevisible; Q8VDT1; MM.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005412; F:glucose:sodium symporter activity; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IBA:GO_Central.
DR Gene3D; 1.20.1730.10; -; 1.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR InterPro; IPR018212; Na/solute_symporter_CS.
DR Pfam; PF00474; SSF; 1.
DR TIGRFAMs; TIGR00813; sss; 1.
DR PROSITE; PS00456; NA_SOLUT_SYMP_1; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Ion transport; Membrane; Reference proteome; Sodium;
KW Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..685
FT /note="Sodium/glucose cotransporter 4"
FT /id="PRO_0000333806"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..71
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..110
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..186
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..213
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 335..379
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..402
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 403..423
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 445..455
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 477..483
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 505..526
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 527..547
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 548..664
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 665..685
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 247
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 190
FT /note="L -> V (in Ref. 2; AAH21357)"
FT /evidence="ECO:0000305"
FT CONFLICT 203
FT /note="T -> A (in Ref. 1; BAC28283)"
FT /evidence="ECO:0000305"
FT CONFLICT 584
FT /note="D -> G (in Ref. 2; AAH21357)"
FT /evidence="ECO:0000305"
FT CONFLICT 685
FT /note="A -> S (in Ref. 2; AAH21357)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 685 AA; 75065 MW; 6D223B4EE896572C CRC64;
MNTELVAMEP GVSRNGVRTE TTTNPSLGLH TYDIVVVVIY FVFVLAVGIW SSIRASRGTV
GGYFLAGRSM TWWPIGASLM SSNVGSGLFI GLAGTGAAGG LAVGGFEWNA TFLLLALGWI
FVPVYIAAGV VTMPQYLKKR FGGQRIQVYM SVLSLILYIF TKISTDIFSG ALFIQMALGW
NLYLSTVILL VVTAVYTIAG GLTAVIYTDA LQTVIMVGGA LVLMFLGFQE VGWYPGLQQL
YRQAIPNTTV PNTTCHLPRP DAFHMLRDPV NGDIPWPGLI FGLTVLATWC WCTDQVIVQR
SLAAKNLSHA KGGSVLGGYL KILPMFFIVM PGMISRALYP DEVACVDPDI CQRVCGARVG
CSNIAYPKLV MALMPVGLRG LMIAVIMAAL MSSLTSIFNS SSTLFAIDVW QRFRRQASEQ
ELMVVGRLFV VFLVVISILW IPIIQSSNSG QLFDYIQSIT SYLAPPITAL FLLAIFCKRV
NEPGAFWGLM FGLVVGILRM ILEFSYSAPA CGEMDRRPAV LKDFHYLYFA LLLCGLTAII
IVVISFFTEP IPDDKLARLT WWTRNCAVSD LQKKTSVSVN NTEDDNSPGL AGRPVVEGPA
GDEEEANTTQ GPEQPGALHR SWGKWLWNWF CGLSGAPQQA LSPAEKAVLE QKLTSIEEEP
LWRRVCNINA IILLAINIFL WGYFA
