SC5AA_BOVIN
ID SC5AA_BOVIN Reviewed; 597 AA.
AC Q6R4Q5;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Sodium/glucose cotransporter 5;
DE Short=Na(+)/glucose cotransporter 5;
DE AltName: Full=Solute carrier family 5 member 10;
GN Name=SLC5A10; Synonyms=SGLT5;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Kidney;
RX PubMed=15591382; DOI=10.3168/jds.s0022-0302(05)72677-1;
RA Zhao F.-Q., Zheng Y.-C., Wall E.H., McFadden T.B.;
RT "Cloning and expression of bovine sodium/glucose cotransporters.";
RL J. Dairy Sci. 88:182-194(2005).
CC -!- FUNCTION: High capacity transporter for mannose and fructose and, to a
CC lesser extent, glucose, AMG, and galactose. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein.
CC -!- TISSUE SPECIFICITY: Expressed only in kidney.
CC {ECO:0000269|PubMed:15591382}.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000305}.
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DR EMBL; AY514442; AAS07045.1; -; mRNA.
DR RefSeq; NP_001001442.1; NM_001001442.1.
DR AlphaFoldDB; Q6R4Q5; -.
DR SMR; Q6R4Q5; -.
DR STRING; 9913.ENSBTAP00000004823; -.
DR PaxDb; Q6R4Q5; -.
DR Ensembl; ENSBTAT00000004823; ENSBTAP00000004823; ENSBTAG00000003700.
DR GeneID; 407227; -.
DR KEGG; bta:407227; -.
DR CTD; 125206; -.
DR VEuPathDB; HostDB:ENSBTAG00000003700; -.
DR VGNC; VGNC:34903; SLC5A10.
DR eggNOG; KOG2349; Eukaryota.
DR GeneTree; ENSGT00940000159416; -.
DR HOGENOM; CLU_018808_9_2_1; -.
DR InParanoid; Q6R4Q5; -.
DR OMA; CWTDLIQ; -.
DR OrthoDB; 243316at2759; -.
DR TreeFam; TF352855; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000003700; Expressed in adult mammalian kidney and 32 other tissues.
DR ExpressionAtlas; Q6R4Q5; baseline.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005412; F:glucose:sodium symporter activity; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IBA:GO_Central.
DR Gene3D; 1.20.1730.10; -; 1.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR InterPro; IPR018212; Na/solute_symporter_CS.
DR Pfam; PF00474; SSF; 1.
DR TIGRFAMs; TIGR00813; sss; 1.
DR PROSITE; PS00457; NA_SOLUT_SYMP_2; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Ion transport; Membrane; Reference proteome;
KW Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..597
FT /note="Sodium/glucose cotransporter 5"
FT /id="PRO_0000311210"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..73
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..174
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..201
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..265
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..301
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 323..367
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 389..410
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 432..444
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 466..472
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 473..493
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 494..514
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 515..535
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 536..576
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 577..597
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 597 AA; 64726 MW; 8EF9B62E705D437E CRC64;
MAVDNSTSDA HTPGRQLTVV DIAIIAVYFA LNVAVGIWSS CRASRNTVRG YFLAGRDMTW
WPIGASLFAS SEGSGLFIGL AGSGAAGGLA VAGFEWNATY VLLALAWVFV PIYLSSEIVT
MPEYMQKRYG GQRIRMYLSV LSLLLSVFTK ISIDLYAGAL FVHICLGWNF YLSTVIMLAI
TALYTIAGGL TAVIYTDALQ TLVMVAGAVI LTIKAFEQIG GYEQLAEAYA QAVPSRTISN
TTCHVPRADA MHMFRDPYTA DLPWTGMTFG LTIMAAWYWC TDQVIVQRSL SARDLNHAKG
GSILASYLKM LPMGLMVMPG MISRVLFPDD VGCVVPAECL RACGAEIGCS NIAYPKLVME
LMPTGLRGLM VAVMMAALMS SLTSIFNSSS TLFTMDIWRR LRPRAGEREL LLVGRLVIVV
LVGVSVAWIP VLQGSNGGQL FIYMQSVTSS LAPPVTAVFV LGIFWRRANE QGAFWGLMAG
LAVGATRLVL EFLHPAPPCG HPDTRPPILH GVHYLHFAVA LFLLSGAVVV AGSLLTPHPQ
GVQIQSLTWW TLAQDLPLGV KTGDGRASQR HAFWARVCGV NAILLMCVNI FFYTYFA
