SC5AA_HUMAN
ID SC5AA_HUMAN Reviewed; 596 AA.
AC A0PJK1; A8MUC9; B4DPI0; B7WPR4; Q6P5X0; Q8IXM4; Q96LQ1;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Sodium/glucose cotransporter 5;
DE Short=Na(+)/glucose cotransporter 5;
DE AltName: Full=Solute carrier family 5 member 10;
GN Name=SLC5A10; Synonyms=SGLT5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 3-596 (ISOFORM 2), AND NUCLEOTIDE SEQUENCE [LARGE
RP SCALE MRNA] OF 6-596 (ISOFORM 1).
RC TISSUE=Brain, and Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141; SER-145 AND THR-148, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND ALTERNATIVE
RP SPLICING (ISOFORMS 1; 2; 4 AND 5).
RX PubMed=22212718; DOI=10.1016/j.febslet.2011.12.027;
RA Grempler R., Augustin R., Froehner S., Hildebrandt T., Simon E., Mark M.,
RA Eickelmann P.;
RT "Functional characterisation of human SGLT-5 as a novel kidney-specific
RT sodium-dependent sugar transporter.";
RL FEBS Lett. 586:248-253(2012).
CC -!- FUNCTION: High capacity transporter for mannose and fructose and, to a
CC lesser extent, glucose, AMG, and galactose.
CC {ECO:0000269|PubMed:22212718}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22212718};
CC Multi-pass membrane protein {ECO:0000269|PubMed:22212718}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1; Synonyms=IF2;
CC IsoId=A0PJK1-1; Sequence=Displayed;
CC Name=2; Synonyms=IF3;
CC IsoId=A0PJK1-2; Sequence=VSP_029417;
CC Name=3;
CC IsoId=A0PJK1-3; Sequence=VSP_029416, VSP_029417, VSP_029418,
CC VSP_029419;
CC Name=4; Synonyms=IF1;
CC IsoId=A0PJK1-4; Sequence=VSP_029418;
CC Name=5; Synonyms=IF4;
CC IsoId=A0PJK1-5; Sequence=VSP_045061;
CC -!- TISSUE SPECIFICITY: Seems to be exclusively expressed in kidney.
CC {ECO:0000269|PubMed:22212718}.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB71619.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK057946; BAB71619.1; ALT_SEQ; mRNA.
DR EMBL; AK298345; BAG60592.1; -; mRNA.
DR EMBL; AC003957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090286; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC034380; AAH34380.1; -; mRNA.
DR EMBL; BC039868; AAH39868.1; -; mRNA.
DR EMBL; BC062617; AAH62617.1; -; mRNA.
DR CCDS; CCDS11201.2; -. [A0PJK1-4]
DR CCDS; CCDS42275.1; -. [A0PJK1-1]
DR CCDS; CCDS59277.1; -. [A0PJK1-5]
DR CCDS; CCDS59278.1; -. [A0PJK1-2]
DR CCDS; CCDS74008.1; -. [A0PJK1-3]
DR RefSeq; NP_001035915.1; NM_001042450.2. [A0PJK1-1]
DR RefSeq; NP_001257577.1; NM_001270648.1. [A0PJK1-2]
DR RefSeq; NP_001257578.1; NM_001270649.1. [A0PJK1-5]
DR RefSeq; NP_001269346.1; NM_001282417.1. [A0PJK1-3]
DR RefSeq; NP_689564.3; NM_152351.4. [A0PJK1-4]
DR AlphaFoldDB; A0PJK1; -.
DR SMR; A0PJK1; -.
DR BioGRID; 125922; 6.
DR STRING; 9606.ENSP00000379008; -.
DR DrugCentral; A0PJK1; -.
DR TCDB; 2.A.21.3.15; the solute:sodium symporter (sss) family.
DR GlyGen; A0PJK1; 2 sites.
DR iPTMnet; A0PJK1; -.
DR PhosphoSitePlus; A0PJK1; -.
DR BioMuta; SLC5A10; -.
DR jPOST; A0PJK1; -.
DR MassIVE; A0PJK1; -.
DR PaxDb; A0PJK1; -.
DR PeptideAtlas; A0PJK1; -.
DR PRIDE; A0PJK1; -.
DR ProteomicsDB; 4787; -.
DR ProteomicsDB; 57; -. [A0PJK1-1]
DR ProteomicsDB; 58; -. [A0PJK1-2]
DR ProteomicsDB; 59; -. [A0PJK1-3]
DR ProteomicsDB; 60; -. [A0PJK1-4]
DR Antibodypedia; 13581; 93 antibodies from 26 providers.
DR DNASU; 125206; -.
DR Ensembl; ENST00000317977.10; ENSP00000324346.6; ENSG00000154025.16. [A0PJK1-3]
DR Ensembl; ENST00000395643.6; ENSP00000379005.2; ENSG00000154025.16. [A0PJK1-2]
DR Ensembl; ENST00000395645.4; ENSP00000379007.3; ENSG00000154025.16. [A0PJK1-1]
DR Ensembl; ENST00000395647.6; ENSP00000379008.2; ENSG00000154025.16. [A0PJK1-4]
DR Ensembl; ENST00000417251.6; ENSP00000401875.2; ENSG00000154025.16. [A0PJK1-5]
DR GeneID; 125206; -.
DR KEGG; hsa:125206; -.
DR MANE-Select; ENST00000395645.4; ENSP00000379007.3; NM_001042450.4; NP_001035915.1.
DR UCSC; uc002gur.3; human. [A0PJK1-1]
DR CTD; 125206; -.
DR DisGeNET; 125206; -.
DR GeneCards; SLC5A10; -.
DR HGNC; HGNC:23155; SLC5A10.
DR HPA; ENSG00000154025; Tissue enriched (kidney).
DR MIM; 618636; gene.
DR neXtProt; NX_A0PJK1; -.
DR OpenTargets; ENSG00000154025; -.
DR PharmGKB; PA134940254; -.
DR VEuPathDB; HostDB:ENSG00000154025; -.
DR eggNOG; KOG2349; Eukaryota.
DR GeneTree; ENSGT00940000159416; -.
DR HOGENOM; CLU_018808_9_2_1; -.
DR InParanoid; A0PJK1; -.
DR OMA; CWTDLIQ; -.
DR OrthoDB; 243316at2759; -.
DR PhylomeDB; A0PJK1; -.
DR TreeFam; TF352855; -.
DR PathwayCommons; A0PJK1; -.
DR Reactome; R-HSA-189200; Cellular hexose transport.
DR BioGRID-ORCS; 125206; 19 hits in 1065 CRISPR screens.
DR ChiTaRS; SLC5A10; human.
DR GenomeRNAi; 125206; -.
DR Pharos; A0PJK1; Tbio.
DR PRO; PR:A0PJK1; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; A0PJK1; protein.
DR Bgee; ENSG00000154025; Expressed in kidney epithelium and 89 other tissues.
DR Genevisible; A0PJK1; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005412; F:glucose:sodium symporter activity; IBA:GO_Central.
DR GO; GO:0015370; F:solute:sodium symporter activity; TAS:Reactome.
DR GO; GO:0008645; P:hexose transmembrane transport; TAS:Reactome.
DR GO; GO:0006814; P:sodium ion transport; IBA:GO_Central.
DR Gene3D; 1.20.1730.10; -; 1.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR InterPro; IPR018212; Na/solute_symporter_CS.
DR Pfam; PF00474; SSF; 1.
DR TIGRFAMs; TIGR00813; sss; 1.
DR PROSITE; PS00457; NA_SOLUT_SYMP_2; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Glycoprotein; Ion transport; Membrane;
KW Phosphoprotein; Reference proteome; Sodium; Sodium transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..596
FT /note="Sodium/glucose cotransporter 5"
FT /id="PRO_0000311211"
FT TOPO_DOM 1..15
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..173
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 195..200
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..264
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..300
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 322..355
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 377..409
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 431..443
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 444..464
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 465..471
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 493..513
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 514..534
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 535..575
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 576..596
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 141
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332"
FT MOD_RES 145
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332"
FT MOD_RES 148
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:19690332"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 96
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..56
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029416"
FT VAR_SEQ 187..213
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029417"
FT VAR_SEQ 327
FT /note="P -> PGAHVYEERHQVSVSRT (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_029418"
FT VAR_SEQ 328..363
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045061"
FT VAR_SEQ 414
FT /note="R -> RTGIPSTPPAPQSRLSFLLPETPPLERYLLGLVVMDLW (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029419"
FT VARIANT 522
FT /note="A -> V (in dbSNP:rs12604020)"
FT /id="VAR_052493"
SQ SEQUENCE 596 AA; 64342 MW; 73D104A9F8065926 CRC64;
MAANSTSDLH TPGTQLSVAD IIVITVYFAL NVAVGIWSSC RASRNTVNGY FLAGRDMTWW
PIGASLFASS EGSGLFIGLA GSGAAGGLAV AGFEWNATYV LLALAWVFVP IYISSEIVTL
PEYIQKRYGG QRIRMYLSVL SLLLSVFTKI SLDLYAGALF VHICLGWNFY LSTILTLGIT
ALYTIAGGLA AVIYTDALQT LIMVVGAVIL TIKAFDQIGG YGQLEAAYAQ AIPSRTIANT
TCHLPRTDAM HMFRDPHTGD LPWTGMTFGL TIMATWYWCT DQVIVQRSLS ARDLNHAKAG
SILASYLKML PMGLIIMPGM ISRALFPDDV GCVVPSECLR ACGAEVGCSN IAYPKLVMEL
MPIGLRGLMI AVMLAALMSS LTSIFNSSST LFTMDIWRRL RPRSGERELL LVGRLVIVAL
IGVSVAWIPV LQDSNSGQLF IYMQSVTSSL APPVTAVFVL GVFWRRANEQ GAFWGLIAGL
VVGATRLVLE FLNPAPPCGE PDTRPAVLGS IHYLHFAVAL FALSGAVVVA GSLLTPPPQS
VQIENLTWWT LAQDVPLGTK AGDGQTPQKH AFWARVCGFN AILLMCVNIF FYAYFA
