SC5AA_PIG
ID SC5AA_PIG Reviewed; 597 AA.
AC Q5FY69;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Sodium/glucose cotransporter 5;
DE Short=Na(+)/glucose cotransporter 5;
DE AltName: Full=Solute carrier family 5 member 10;
GN Name=SLC5A10; Synonyms=SGLT1, SGLT5;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney;
RA Honscha K.U., Urbansky I., Gabel G., Aschenbach J.R.;
RT "Cloning and functional characterization of porcine SGLT1.";
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: High capacity transporter for mannose and fructose and, to a
CC lesser extent, glucose, AMG, and galactose. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000305}.
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DR EMBL; AY876919; AAW69922.1; -; mRNA.
DR RefSeq; NP_001012297.1; NM_001012297.1.
DR AlphaFoldDB; Q5FY69; -.
DR SMR; Q5FY69; -.
DR STRING; 9823.ENSSSCP00000019123; -.
DR PaxDb; Q5FY69; -.
DR GeneID; 497235; -.
DR KEGG; ssc:497235; -.
DR CTD; 125206; -.
DR eggNOG; KOG2349; Eukaryota.
DR InParanoid; Q5FY69; -.
DR OrthoDB; 243316at2759; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1730.10; -; 1.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR InterPro; IPR018212; Na/solute_symporter_CS.
DR Pfam; PF00474; SSF; 1.
DR TIGRFAMs; TIGR00813; sss; 1.
DR PROSITE; PS00457; NA_SOLUT_SYMP_2; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Ion transport; Membrane; Phosphoprotein;
KW Reference proteome; Sodium; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..597
FT /note="Sodium/glucose cotransporter 5"
FT /id="PRO_0000311213"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..73
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..174
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..201
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..265
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..301
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 323..367
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 389..410
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 432..444
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 466..472
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 473..493
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 494..514
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 515..535
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 536..576
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 577..597
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 49
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5SWY8"
FT MOD_RES 142
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A0PJK1"
FT MOD_RES 146
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A0PJK1"
FT MOD_RES 149
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:A0PJK1"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 597 AA; 64437 MW; D9F846E24CCFD8B8 CRC64;
MAADNSSSDP HAPGPQLSVA DVVIVAVYFA VNMAVGVWSS CRASRNTVSG YFLAGRDMMW
RPIGASLFAS SEGSGLFVGL AGSGAAGGLA VAGFEWHATY VLLALAWVFV PIYISSEIVT
MPEYIQKRYG GQRIRMYLSV LSLLLSIFTK ISIDLYAGAL FVHICLGWNF YLSTCLMLVI
TALYTIAGGL AAVIYTDALQ TLIMVVGAVI LTVKAFQQIG GYEQLAAAYA QAIPSKTISN
TTCHLPRADA MHMFRDPATG DLPWTGMTFG LTIMATWYWC TDQVIVQRSL SARDLNHAKG
GSILASYLKM LPMGLMVMPG MISRVLFPDD VGCVVPSECL RACGAEIGCS NIAYPKLVME
LMPTGLRGLM VAVMMAALMS SLTSIFNSSS TLFTMDVWRR LRPRAGEREL LLVGRLVIVV
LIGVSVAWIP VLQGSNSGQL FIYMQSVTSS LAPPVTAVFV LGIFWRRANE QGAFWGLMVG
LAVGAWRLVL EFLHPAPPCG HPDVRPALLR TVHYLHFAVA LFVLSGAVVA AVSLLTPPPA
GVQIENLTWW TLARDRPSGA KTGDGPASQK HAFWARVCSL NAVLLVCVNL FFYAYFA
