SC5AA_RABIT
ID SC5AA_RABIT Reviewed; 597 AA.
AC Q28610;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Sodium/glucose cotransporter 5;
DE Short=Na(+)/glucose cotransporter 5;
DE AltName: Full=RK-D;
DE AltName: Full=Solute carrier family 5 member 10;
GN Name=SLC5A10; Synonyms=SGLT5;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Kidney;
RX PubMed=7918548; DOI=10.1016/0005-2736(94)90319-0;
RA Pajor A.M.;
RT "Sequence of a putative transporter from rabbit kidney related to the
RT Na+/glucose cotransporter gene family.";
RL Biochim. Biophys. Acta 1194:349-351(1994).
CC -!- FUNCTION: High capacity transporter for mannose and fructose and, to a
CC lesser extent, glucose, AMG, and galactose. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein.
CC -!- TISSUE SPECIFICITY: Expressed only in kidney.
CC {ECO:0000269|PubMed:7918548}.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000305}.
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DR EMBL; U08813; AAA66065.1; -; mRNA.
DR RefSeq; NP_001076168.1; NM_001082699.1.
DR AlphaFoldDB; Q28610; -.
DR SMR; Q28610; -.
DR STRING; 9986.ENSOCUP00000013590; -.
DR PRIDE; Q28610; -.
DR GeneID; 100009432; -.
DR KEGG; ocu:100009432; -.
DR CTD; 125206; -.
DR eggNOG; KOG2349; Eukaryota.
DR InParanoid; Q28610; -.
DR OrthoDB; 243316at2759; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1730.10; -; 1.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR InterPro; IPR018212; Na/solute_symporter_CS.
DR Pfam; PF00474; SSF; 1.
DR TIGRFAMs; TIGR00813; sss; 1.
DR PROSITE; PS00457; NA_SOLUT_SYMP_2; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Ion transport; Membrane; Phosphoprotein;
KW Reference proteome; Sodium; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..597
FT /note="Sodium/glucose cotransporter 5"
FT /id="PRO_0000311214"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..73
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..171
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 195..200
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..265
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..301
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 323..367
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 391..410
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 432..444
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 466..472
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 473..493
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 494..514
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 515..535
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 536..576
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 577..597
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 49
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5SWY8"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 597 AA; 64650 MW; 8F1A075481D02FCC CRC64;
MVADNSTSDP HAPGPQLSVT DIVVITVYFA LNVAVGIWSS CRASRNTVSG YFLAGRDMTW
WPIGASLFGS SEGSGLFIGL AGSGAAGGLA VAGFDWNATY VLLALAWVFG AIYISSEIVT
LAEYIQKRFG GQRIRMYLSV LSLLLSVFTK ISLDLYAGAL FVHICLGWNF YLSTILTLTI
TALYTITGGL VAVIYTDALQ TLIMVVGAVI LAIKAFHQID GYGQMEAAYA RAIPSRTVAN
TTCHLPRADA MHMFRDPYTG DLPWTGMTFG LTIMATWYWC TDQVIVQRSL SARNLNHAKA
GSILASYLKM LPMGLMIMPG MISRALFPDE VGCVVPSECL RACGAEIGCS NIAYPKLVME
LMPVGLRGLM IAVMMPALMS SLSSIFNSSS TLFTMDIWRR LRPCASEREL LLVGRLVIVV
LIGVSVAWIP VLQGSNGGQL FIYMQSVTSS LAPPVTAVFT LGIFWQRANE QGAFWGLLAG
LAVGATRLVL EFLHPAPPCG AADTRPAVLS QLHYLHFAVA LFVLTGAVAV GGSLLTPPPR
RHQIENLTWW TLTRDLSLGA KAGDGQTPQR YTFWARVCGF NAILLMCVNI FFYAYFA
