SC5AB_BOVIN
ID SC5AB_BOVIN Reviewed; 674 AA.
AC Q3ZC26;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Sodium/myo-inositol cotransporter 2;
DE Short=Na(+)/myo-inositol cotransporter 2;
DE AltName: Full=Sodium/myo-inositol transporter 2;
DE Short=SMIT2;
DE AltName: Full=Solute carrier family 5 member 11;
GN Name=SLC5A11 {ECO:0000312|EMBL:AAI02963.1};
GN Synonyms=SMIT2 {ECO:0000250|UniProtKB:Q28728};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1] {ECO:0000312|EMBL:AAI02963.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus {ECO:0000312|EMBL:AAI02963.1};
RC TISSUE=Ileum {ECO:0000312|EMBL:AAI02963.1};
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the sodium-dependent cotransport of myo-inositol
CC (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for
CC apical MI transport and absorption in intestine. Can also transport D-
CC chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific
CC cotransport of both D-glucose and D-xylose. May induce apoptosis
CC through the TNF-alpha, PDCD1 pathway. May play a role in the regulation
CC of MI concentration in serum, involving reabsorption in at least the
CC proximal tubule of the kidney.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q28728}; Multi-
CC pass membrane protein {ECO:0000250|UniProtKB:Q28728}.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000255}.
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DR EMBL; BC102962; AAI02963.1; -; mRNA.
DR RefSeq; NP_001029832.1; NM_001034660.2.
DR RefSeq; XP_005224816.1; XM_005224759.3.
DR AlphaFoldDB; Q3ZC26; -.
DR SMR; Q3ZC26; -.
DR STRING; 9913.ENSBTAP00000004510; -.
DR PaxDb; Q3ZC26; -.
DR GeneID; 539084; -.
DR KEGG; bta:539084; -.
DR CTD; 115584; -.
DR eggNOG; KOG2349; Eukaryota.
DR HOGENOM; CLU_018808_9_2_1; -.
DR InParanoid; Q3ZC26; -.
DR OrthoDB; 243316at2759; -.
DR TreeFam; TF352855; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005412; F:glucose:sodium symporter activity; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1730.10; -; 1.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR Pfam; PF00474; SSF; 1.
DR TIGRFAMs; TIGR00813; sss; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Ion transport; Membrane; Reference proteome; Sodium;
KW Sodium transport; Sugar transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..674
FT /note="Sodium/myo-inositol cotransporter 2"
FT /id="PRO_0000331567"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..180
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202..208
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..308
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 330..374
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 398..418
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 440..446
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 468..479
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 501..521
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 522..542
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 543..653
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 654..674
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 567..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 674 AA; 73957 MW; EDD042B64AE749B5 CRC64;
MESSASSPPL TQSDPLEAFP RRTLEAGDIA VLVLYFLFVL AVGLWSTVKT KRDTVKGYFL
AGGNMLWWPV GASLFASNVG SGHFVGLAGS GAAAGLSVTA YELNGLFFVL MLSWIFLPIY
ITGQVTTMPE YLRKRFGGNR IPIILAVLYL FIYIFTKISV DMYAGAIFIQ QSLHVNLYLA
IVGLLAVTAL YTIAGGLAAV IYTDALQTLI MLIGALILMG YSFAAVGGLE GLEEKYFLAM
ASNRSGNSSC GLPREDAFHI FRDPVTSDLP WPGILFGMSI PSLWYWCTDQ VIVQRTLAAK
NLSHAKGGSL MAAYLKVLPL FIMVFPGMVS RVLFPDEVAC ADPEICRKVC SNPAGCSDIA
YPKLVLELLP TGLRGLMMAV MVAALTSSLT SIFNSASTIF TMDLWNHLRP RASEKELMIV
GRVFVLLLVL VSILWIPVVQ ASQGGQLFIY IQSISSYLQP PVAVVFIMGC FWKRANEKGA
FFGLVLGLLL GLVRLILDFI YVQPRCDQLD ERPAVVKDVH YLYFSMILSS VTLITVCAVS
WFTEPPSKEM VSRLTWFTRH DPVVQKEQVP SATPPPLTLS QNGTPEASGT NTQFEMVQEN
LSKTHSCDMT TKRSKVVKAI LWLCGVENKG KEQAPSRADP IIVSLEENPL VKTLLDLNLI
ICISCAIFLW GYFA
