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SC61A_HALRO
ID   SC61A_HALRO             Reviewed;         475 AA.
AC   Q25147; Q25146;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Protein transport protein Sec61 subunit alpha;
OS   Halocynthia roretzi (Sea squirt) (Cynthia roretzi).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Stolidobranchia;
OC   Pyuridae; Halocynthia.
OX   NCBI_TaxID=7729;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=8088436; DOI=10.1006/dbio.1994.1245;
RA   Ueki T., Satoh N.;
RT   "An ascidian homolog of SEC61 is expressed predominantly in epidermal cells
RT   of the embryo.";
RL   Dev. Biol. 165:185-192(1994).
CC   -!- FUNCTION: Plays a crucial role in the insertion of secretory and
CC       membrane polypeptides into the ER. Required for assembly of membrane
CC       and secretory proteins. Tightly associated with membrane-bound
CC       ribosomes, either directly or through adapter proteins (By similarity).
CC       Plays a role in pronephric kidney tubule development (By similarity).
CC       {ECO:0000250, ECO:0000250|UniProtKB:P61620}.
CC   -!- SUBUNIT: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and
CC       SEC61-gamma.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:P61619}; Multi-pass membrane protein
CC       {ECO:0000305}. Note=Localizes exclusively in granular structures in the
CC       endoplasmic reticulum (ER). {ECO:0000250|UniProtKB:P61619}.
CC   -!- TISSUE SPECIFICITY: Expressed predominantly in epidermal cells of the
CC       embryo.
CC   -!- SIMILARITY: Belongs to the SecY/SEC61-alpha family. {ECO:0000305}.
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DR   EMBL; D25536; BAA05019.1; -; mRNA.
DR   EMBL; D50328; BAA08864.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q25147; -.
DR   SMR; Q25147; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0039019; P:pronephric nephron development; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3370.10; -; 1.
DR   InterPro; IPR002208; SecY/SEC61-alpha.
DR   InterPro; IPR030659; SecY_CS.
DR   InterPro; IPR023201; SecY_dom_sf.
DR   InterPro; IPR019561; Translocon_Sec61/SecY_plug_dom.
DR   PANTHER; PTHR10906; PTHR10906; 1.
DR   Pfam; PF10559; Plug_translocon; 1.
DR   Pfam; PF00344; SecY; 1.
DR   PIRSF; PIRSF004557; SecY; 1.
DR   SUPFAM; SSF103491; SSF103491; 1.
DR   TIGRFAMs; TIGR00967; 3a0501s007; 1.
DR   PROSITE; PS00755; SECY_1; 1.
DR   PROSITE; PS00756; SECY_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Endoplasmic reticulum; Membrane; Protein transport;
KW   Translocation; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..475
FT                   /note="Protein transport protein Sec61 subunit alpha"
FT                   /id="PRO_0000131809"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        354..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        420..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        441..461
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   475 AA;  52473 MW;  C701D70781A568BB CRC64;
     MGFKFLEVIK PFCIILPEIE KPQRKIQFRE KVLWTAITLF IFLVCCQIPL FGIMSSESAD
     PFYWMRVIMA SNRGTLMELG ITPIVTSGLI MQLLAGAKLI EVGDTPKDRA LFNGAQKLFG
     MIITIGQAVV YVMTGMYGDP SDMGAGICLL IIIQLFIASL IVLLLDELLQ KGYGLGSGIS
     LFIATNICET IVWKSFSPAT VNTGRGTEFE GAVIALFHLL ATRSDKVRAL REAFYRPNLP
     NLMNLSATIL VFGIVIYFQG FRVDLPIKSA RYRGQYSSYP IKLFYTSNIP IILQSALVSG
     LYVISQMLAI RFRGNFFIGL LGVWEDVEGG GPARSYPVAL CYYLSPPESF FSMFLDPIHG
     LLYITFMLGS CAFFSKTWIE VSGSAAKDVA KQLKEQQMVM RGHREKSMIH ELNRYIPTAA
     AFGGLCIGAL SVLADFIGAI GSGTGILLAV TIIYQYFEIF VKEQAEVGGM GTLLF
 
 
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