SC61A_HALRO
ID SC61A_HALRO Reviewed; 475 AA.
AC Q25147; Q25146;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Protein transport protein Sec61 subunit alpha;
OS Halocynthia roretzi (Sea squirt) (Cynthia roretzi).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Stolidobranchia;
OC Pyuridae; Halocynthia.
OX NCBI_TaxID=7729;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=8088436; DOI=10.1006/dbio.1994.1245;
RA Ueki T., Satoh N.;
RT "An ascidian homolog of SEC61 is expressed predominantly in epidermal cells
RT of the embryo.";
RL Dev. Biol. 165:185-192(1994).
CC -!- FUNCTION: Plays a crucial role in the insertion of secretory and
CC membrane polypeptides into the ER. Required for assembly of membrane
CC and secretory proteins. Tightly associated with membrane-bound
CC ribosomes, either directly or through adapter proteins (By similarity).
CC Plays a role in pronephric kidney tubule development (By similarity).
CC {ECO:0000250, ECO:0000250|UniProtKB:P61620}.
CC -!- SUBUNIT: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and
CC SEC61-gamma.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P61619}; Multi-pass membrane protein
CC {ECO:0000305}. Note=Localizes exclusively in granular structures in the
CC endoplasmic reticulum (ER). {ECO:0000250|UniProtKB:P61619}.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in epidermal cells of the
CC embryo.
CC -!- SIMILARITY: Belongs to the SecY/SEC61-alpha family. {ECO:0000305}.
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DR EMBL; D25536; BAA05019.1; -; mRNA.
DR EMBL; D50328; BAA08864.1; -; Genomic_DNA.
DR AlphaFoldDB; Q25147; -.
DR SMR; Q25147; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0039019; P:pronephric nephron development; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3370.10; -; 1.
DR InterPro; IPR002208; SecY/SEC61-alpha.
DR InterPro; IPR030659; SecY_CS.
DR InterPro; IPR023201; SecY_dom_sf.
DR InterPro; IPR019561; Translocon_Sec61/SecY_plug_dom.
DR PANTHER; PTHR10906; PTHR10906; 1.
DR Pfam; PF10559; Plug_translocon; 1.
DR Pfam; PF00344; SecY; 1.
DR PIRSF; PIRSF004557; SecY; 1.
DR SUPFAM; SSF103491; SSF103491; 1.
DR TIGRFAMs; TIGR00967; 3a0501s007; 1.
DR PROSITE; PS00755; SECY_1; 1.
DR PROSITE; PS00756; SECY_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Endoplasmic reticulum; Membrane; Protein transport;
KW Translocation; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..475
FT /note="Protein transport protein Sec61 subunit alpha"
FT /id="PRO_0000131809"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 420..440
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 475 AA; 52473 MW; C701D70781A568BB CRC64;
MGFKFLEVIK PFCIILPEIE KPQRKIQFRE KVLWTAITLF IFLVCCQIPL FGIMSSESAD
PFYWMRVIMA SNRGTLMELG ITPIVTSGLI MQLLAGAKLI EVGDTPKDRA LFNGAQKLFG
MIITIGQAVV YVMTGMYGDP SDMGAGICLL IIIQLFIASL IVLLLDELLQ KGYGLGSGIS
LFIATNICET IVWKSFSPAT VNTGRGTEFE GAVIALFHLL ATRSDKVRAL REAFYRPNLP
NLMNLSATIL VFGIVIYFQG FRVDLPIKSA RYRGQYSSYP IKLFYTSNIP IILQSALVSG
LYVISQMLAI RFRGNFFIGL LGVWEDVEGG GPARSYPVAL CYYLSPPESF FSMFLDPIHG
LLYITFMLGS CAFFSKTWIE VSGSAAKDVA KQLKEQQMVM RGHREKSMIH ELNRYIPTAA
AFGGLCIGAL SVLADFIGAI GSGTGILLAV TIIYQYFEIF VKEQAEVGGM GTLLF