SC61A_PYRSA
ID SC61A_PYRSA Reviewed; 494 AA.
AC P38379;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Protein transport protein Sec61 subunit alpha;
OS Pyrenomonas salina.
OC Eukaryota; Cryptophyceae; Pyrenomonadales; Pyrenomonadaceae; Pyrenomonas.
OX NCBI_TaxID=3034;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7874733; DOI=10.1007/bf00309927;
RA Mueller S.B., Rensing S.A., Martin W.F., Maier U.-G.;
RT "cDNA cloning of a Sec61 homologue from the cryptomonad alga Pyrenomonas
RT salina.";
RL Curr. Genet. 26:410-414(1994).
CC -!- FUNCTION: Appears to play a crucial role in the insertion of secretory
CC and membrane polypeptides into the ER. It is required for assembly of
CC membrane and secretory proteins.
CC -!- SUBUNIT: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and
CC SEC61-gamma.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the SecY/SEC61-alpha family. {ECO:0000305}.
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DR EMBL; X77805; CAA54828.1; -; mRNA.
DR PIR; S51499; S51499.
DR AlphaFoldDB; P38379; -.
DR SMR; P38379; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3370.10; -; 1.
DR InterPro; IPR002208; SecY/SEC61-alpha.
DR InterPro; IPR030659; SecY_CS.
DR InterPro; IPR023201; SecY_dom_sf.
DR InterPro; IPR019561; Translocon_Sec61/SecY_plug_dom.
DR PANTHER; PTHR10906; PTHR10906; 1.
DR Pfam; PF10559; Plug_translocon; 1.
DR Pfam; PF00344; SecY; 1.
DR PIRSF; PIRSF004557; SecY; 1.
DR SUPFAM; SSF103491; SSF103491; 1.
DR TIGRFAMs; TIGR00967; 3a0501s007; 1.
DR PROSITE; PS00755; SECY_1; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Membrane; Protein transport; Translocation;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..494
FT /note="Protein transport protein Sec61 subunit alpha"
FT /id="PRO_0000131810"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 426..446
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 450..470
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 494 AA; 54286 MW; E2DDCD9BB4358966 CRC64;
MGTSGVRFLT LVKPFMFALP EVSSATKKIP VNEKLLWTSI VVFLYLVCCQ IPLYGITNTK
SSDPFYWMRV ILASNKGTLM ELGISPIVTS GLVMQLLAGS KIIDVDQGTK EDKTLFQGAQ
KLLGILITIG ESVAYVLSGM YGDVKDLGAG NAILIIVQLF TSGIIVICLD ELLQKGYGIG
SAISLFIATN VCESIVWKSF SPTTINTGRG TEFEGALVAL FQLMITKTDK VRALQEAFYR
QNLPNVTNLL ATVLVFVLVV YFQGFQVELP ITPAKSKGMA GQFYPIKLFY TSNMPIILQT
ALVSNLYFIS QILYKRYPEN IIIHILGRWE EPEMSVSGQM RPVGGIAYYI SPLNSFAEIV
SDPVHALLYI IFILASCALF SKTWIQVSGT SASDVSKQLR DQQMVMKGFR ASSMQRELNR
YIPTAAAFGG MCIGALSIVA DFMGAIGSGT GILLAVTTIY QSWETILLAV TTIYQSWETI
RKESRDTDAL KMFG
