SC61B_ARATH
ID SC61B_ARATH Reviewed; 82 AA.
AC P38389;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Protein transport protein Sec61 subunit beta;
GN OrderedLocusNames=At2g45070; ORFNames=T14P1.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8107851; DOI=10.1038/367654a0;
RA Hartmann E., Sommer T., Prehn S., Goerlich D., Jentsch S., Rapoport T.A.;
RT "Evolutionary conservation of components of the protein translocation
RT complex.";
RL Nature 367:654-657(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA Giglione C.;
RT "Comparative large-scale characterisation of plant vs. mammal proteins
RT reveals similar and idiosyncratic N-alpha acetylation features.";
RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
CC -!- FUNCTION: Necessary for protein translocation in the endoplasmic
CC reticulum.
CC -!- SUBUNIT: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and
CC SEC61-gamma.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the SEC61-beta family. {ECO:0000305}.
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DR EMBL; Z26753; CAA81412.1; -; mRNA.
DR EMBL; CP002685; AEC10502.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10503.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10504.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10505.1; -; Genomic_DNA.
DR EMBL; BT000904; AAN41304.1; -; mRNA.
DR PIR; T52378; T52378.
DR RefSeq; NP_001031539.1; NM_001036462.1.
DR RefSeq; NP_001031540.1; NM_001036463.2.
DR RefSeq; NP_001078061.1; NM_001084592.2.
DR RefSeq; NP_182033.1; NM_130071.4.
DR AlphaFoldDB; P38389; -.
DR BioGRID; 4450; 27.
DR IntAct; P38389; 27.
DR STRING; 3702.AT2G45070.4; -.
DR iPTMnet; P38389; -.
DR MetOSite; P38389; -.
DR PaxDb; P38389; -.
DR PRIDE; P38389; -.
DR ProteomicsDB; 226597; -.
DR EnsemblPlants; AT2G45070.1; AT2G45070.1; AT2G45070.
DR EnsemblPlants; AT2G45070.2; AT2G45070.2; AT2G45070.
DR EnsemblPlants; AT2G45070.3; AT2G45070.3; AT2G45070.
DR EnsemblPlants; AT2G45070.4; AT2G45070.4; AT2G45070.
DR GeneID; 819114; -.
DR Gramene; AT2G45070.1; AT2G45070.1; AT2G45070.
DR Gramene; AT2G45070.2; AT2G45070.2; AT2G45070.
DR Gramene; AT2G45070.3; AT2G45070.3; AT2G45070.
DR Gramene; AT2G45070.4; AT2G45070.4; AT2G45070.
DR KEGG; ath:AT2G45070; -.
DR Araport; AT2G45070; -.
DR TAIR; locus:2055567; AT2G45070.
DR eggNOG; KOG3457; Eukaryota.
DR HOGENOM; CLU_133423_3_0_1; -.
DR InParanoid; P38389; -.
DR OMA; KYTRSHH; -.
DR OrthoDB; 1634609at2759; -.
DR PhylomeDB; P38389; -.
DR PRO; PR:P38389; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; P38389; baseline and differential.
DR Genevisible; P38389; AT.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IPI:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005784; C:Sec61 translocon complex; IEA:InterPro.
DR GO; GO:0031204; P:post-translational protein targeting to membrane, translocation; IBA:GO_Central.
DR GO; GO:0006616; P:SRP-dependent cotranslational protein targeting to membrane, translocation; IBA:GO_Central.
DR InterPro; IPR030671; Sec61-beta/Sbh.
DR InterPro; IPR016482; SecG/Sec61-beta/Sbh.
DR PANTHER; PTHR13509; PTHR13509; 1.
DR Pfam; PF03911; Sec61_beta; 1.
DR PIRSF; PIRSF006398; Sec61_beta_euk; 1.
PE 1: Evidence at protein level;
KW Acetylation; Endoplasmic reticulum; Membrane; Protein transport;
KW Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..82
FT /note="Protein transport protein Sec61 subunit beta"
FT /id="PRO_0000157257"
FT TOPO_DOM 1..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22223895"
SQ SEQUENCE 82 AA; 8217 MW; 5CA3EC83818EFD2F CRC64;
MVGSGAPQRG SAAATASMRR RKPTSGAGGG GASGGAAGSM LQFYTDDAPG LKISPNVVLI
MSIGFIAFVA VLHVMGKLYF VK
