ID   SC61B_DICDI             Reviewed;          61 AA.
AC   Q54YR4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Protein transport protein Sec61 subunit beta;
GN   Name=sec61b; ORFNames=DDB_G0278117;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Necessary for protein translocation in the endoplasmic
CC       reticulum. {ECO:0000250}.
CC   -!- SUBUNIT: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and
CC       SEC61-gamma. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SEC61-beta family. {ECO:0000305}.
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DR   EMBL; AAFI02000023; EAL68231.1; -; Genomic_DNA.
DR   RefSeq; XP_642138.1; XM_637046.1.
DR   AlphaFoldDB; Q54YR4; -.
DR   SMR; Q54YR4; -.
DR   STRING; 44689.DDB0235194; -.
DR   PaxDb; Q54YR4; -.
DR   EnsemblProtists; EAL68231; EAL68231; DDB_G0278117.
DR   GeneID; 8621346; -.
DR   KEGG; ddi:DDB_G0278117; -.
DR   dictyBase; DDB_G0278117; sec61b.
DR   eggNOG; KOG3457; Eukaryota.
DR   HOGENOM; CLU_133423_1_2_1; -.
DR   InParanoid; Q54YR4; -.
DR   OMA; FRKNASC; -.
DR   PhylomeDB; Q54YR4; -.
DR   Reactome; R-DDI-9609523; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
DR   PRO; PR:Q54YR4; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005784; C:Sec61 translocon complex; ISS:dictyBase.
DR   GO; GO:0006613; P:cotranslational protein targeting to membrane; ISS:dictyBase.
DR   GO; GO:0031204; P:post-translational protein targeting to membrane, translocation; IBA:GO_Central.
DR   GO; GO:0006616; P:SRP-dependent cotranslational protein targeting to membrane, translocation; IBA:GO_Central.
DR   InterPro; IPR030671; Sec61-beta/Sbh.
DR   InterPro; IPR016482; SecG/Sec61-beta/Sbh.
DR   PANTHER; PTHR13509; PTHR13509; 1.
DR   Pfam; PF03911; Sec61_beta; 1.
DR   PIRSF; PIRSF006398; Sec61_beta_euk; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Protein transport; Reference proteome;
KW   Translocation; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..61
FT                   /note="Protein transport protein Sec61 subunit beta"
FT                   /id="PRO_0000328022"
FT   TOPO_DOM        1..35
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        57..61
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   61 AA;  6736 MW;  7E06E6874EA1F3C9 CRC64;
     MKRPSTQRAP ATVNKGGNSM MKFYSEDAIG LKVGPTAVLF MSLIFIAFVI ILHIMGKYTR
     S