ID   SC61B_KLULA             Reviewed;          88 AA.
AC   Q8J2P4;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Protein transport protein Sec61 subunit beta;
GN   Name=SBH1; Synonyms=SEB1; OrderedLocusNames=KLLA0E19921g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Sundqvist L., Toikkanen J., Keranen S.;
RT   "Kluyveromyces lactis SEB1 gene.";
RL   Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Necessary for protein translocation in the endoplasmic
CC       reticulum. {ECO:0000250}.
CC   -!- SUBUNIT: Heterotrimeric complex composed of SEC61, SEB1 and SSS1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SEC61-beta family. {ECO:0000305}.
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DR   EMBL; AF318314; AAN39012.1; -; Genomic_DNA.
DR   EMBL; CR382125; CAG99935.1; -; Genomic_DNA.
DR   RefSeq; XP_454848.1; XM_454848.1.
DR   AlphaFoldDB; Q8J2P4; -.
DR   SMR; Q8J2P4; -.
DR   STRING; 28985.XP_454848.1; -.
DR   EnsemblFungi; CAG99935; CAG99935; KLLA0_E19823g.
DR   GeneID; 2894724; -.
DR   KEGG; kla:KLLA0_E19823g; -.
DR   eggNOG; KOG3457; Eukaryota.
DR   HOGENOM; CLU_133423_1_1_1; -.
DR   InParanoid; Q8J2P4; -.
DR   OMA; WGKYTRG; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:EnsemblFungi.
DR   GO; GO:0005784; C:Sec61 translocon complex; IEA:InterPro.
DR   GO; GO:0071261; C:Ssh1 translocon complex; IEA:EnsemblFungi.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:EnsemblFungi.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:EnsemblFungi.
DR   InterPro; IPR030671; Sec61-beta/Sbh.
DR   InterPro; IPR016482; SecG/Sec61-beta/Sbh.
DR   PANTHER; PTHR13509; PTHR13509; 1.
DR   Pfam; PF03911; Sec61_beta; 1.
DR   PIRSF; PIRSF006398; Sec61_beta_euk; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Protein transport; Reference proteome;
KW   Translocation; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..88
FT                   /note="Protein transport protein Sec61 subunit beta"
FT                   /id="PRO_0000157258"
FT   TOPO_DOM        1..60
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   88 AA;  9428 MW;  F7632A787FFE68A0 CRC64;
     MDSSVPGGQR TLQKRRNAQL QKEKKANQTP ASPRQAGFGG SSSSILKLYT DEANGLRVDP
     LVVLFLAVAF VFSVVALHVV AKVSGKIF