SC61G_MOUSE
ID SC61G_MOUSE Reviewed; 68 AA.
AC P60060; P38384;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 21-NOV-2003, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Protein transport protein Sec61 subunit gamma;
GN Name=Sec61g;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Calvaria;
RA Yotov W.V., St Arnaud R.;
RT "Nucleotide sequence of the mouse Sec61-gamma cDNA.";
RL Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of SEC61 channel-forming translocon complex that
CC mediates transport of signal peptide-containing precursor polypeptides
CC across endoplasmic reticulum (ER) (By similarity). Component of a
CC ribosome-associated ER translocon complex involved in multi-pass
CC membrane protein transport into the ER membrane and biogenesis (By
CC similarity). The SEC61 channel cooperates with the translocating
CC protein TRAM1 to import nascent proteins into the ER (By similarity).
CC {ECO:0000250|UniProtKB:P60058, ECO:0000250|UniProtKB:P60059,
CC ECO:0000250|UniProtKB:P61619}.
CC -!- SUBUNIT: The SEC61 channel-forming translocon complex consists of
CC channel-forming core components SEC61A1, SEC61B and SEC61G and
CC different auxiliary components such as SEC62 and SEC63 (By similarity).
CC The ribosome-associated ER translocon complex includes SEC61A1, SEC61B,
CC SEC61G, TMCO1, CCDC47, NCLN/Nicalin, NOMO and TMEM147; in the absence
CC of ribosomes, only the complex forms with NCLN/Nicalin, NOMO and
CC TMEM147 remains intact (By similarity). {ECO:0000250|UniProtKB:P60058,
CC ECO:0000250|UniProtKB:P60059}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P60058}; Single-pass membrane protein
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SecE/SEC61-gamma family. {ECO:0000305}.
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DR EMBL; U11027; AAA19431.1; -; mRNA.
DR EMBL; AK012393; BAB28210.1; -; mRNA.
DR EMBL; AK012644; BAB28376.1; -; mRNA.
DR EMBL; BC019158; AAH19158.1; -; mRNA.
DR EMBL; BC081456; AAH81456.1; -; mRNA.
DR CCDS; CCDS48755.1; -.
DR RefSeq; NP_001103441.1; NM_001109971.1.
DR RefSeq; NP_001103442.1; NM_001109972.1.
DR RefSeq; NP_035473.2; NM_011343.3.
DR RefSeq; XP_006496454.1; XM_006496391.3.
DR RefSeq; XP_006514454.1; XM_006514391.1.
DR AlphaFoldDB; P60060; -.
DR SMR; P60060; -.
DR BioGRID; 203151; 1.
DR IntAct; P60060; 1.
DR STRING; 10090.ENSMUSP00000132348; -.
DR PhosphoSitePlus; P60060; -.
DR jPOST; P60060; -.
DR PaxDb; P60060; -.
DR PeptideAtlas; P60060; -.
DR PRIDE; P60060; -.
DR ProteomicsDB; 256735; -.
DR TopDownProteomics; P60060; -.
DR Antibodypedia; 44752; 73 antibodies from 18 providers.
DR DNASU; 20335; -.
DR Ensembl; ENSMUST00000109641; ENSMUSP00000105269; ENSMUSG00000078974.
DR Ensembl; ENSMUST00000109642; ENSMUSP00000105270; ENSMUSG00000078974.
DR Ensembl; ENSMUST00000109643; ENSMUSP00000105271; ENSMUSG00000078974.
DR Ensembl; ENSMUST00000178855; ENSMUSP00000137362; ENSMUSG00000078974.
DR GeneID; 20335; -.
DR KEGG; mmu:20335; -.
DR UCSC; uc007ibl.2; mouse.
DR CTD; 23480; -.
DR MGI; MGI:1202066; Sec61g.
DR VEuPathDB; HostDB:ENSMUSG00000078974; -.
DR eggNOG; KOG3498; Eukaryota.
DR GeneTree; ENSGT00390000001319; -.
DR HOGENOM; CLU_167752_2_0_1; -.
DR InParanoid; P60060; -.
DR OMA; RDGNQFL; -.
DR OrthoDB; 1623399at2759; -.
DR PhylomeDB; P60060; -.
DR Reactome; R-MMU-9609523; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
DR BioGRID-ORCS; 20335; 5 hits in 37 CRISPR screens.
DR ChiTaRS; Sec61g; mouse.
DR PRO; PR:P60060; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P60060; protein.
DR Bgee; ENSMUSG00000078974; Expressed in epiblast (generic) and 69 other tissues.
DR ExpressionAtlas; P60060; baseline and differential.
DR Genevisible; P60060; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0071261; C:Ssh1 translocon complex; IBA:GO_Central.
DR GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR GO; GO:0031204; P:post-translational protein targeting to membrane, translocation; IBA:GO_Central.
DR Gene3D; 1.20.5.820; -; 1.
DR HAMAP; MF_00422; SecE; 1.
DR InterPro; IPR023391; Prot_translocase_SecE_dom_sf.
DR InterPro; IPR008158; Translocase_Sec61-g.
DR InterPro; IPR001901; Translocase_SecE/Sec61-g.
DR Pfam; PF00584; SecE; 1.
DR SUPFAM; SSF103456; SSF103456; 1.
DR TIGRFAMs; TIGR00327; secE_euk_arch; 1.
DR PROSITE; PS01067; SECE_SEC61G; 1.
PE 3: Inferred from homology;
KW Acetylation; Endoplasmic reticulum; Membrane; Phosphoprotein;
KW Protein transport; Reference proteome; Translocation; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..68
FT /note="Protein transport protein Sec61 subunit gamma"
FT /id="PRO_0000104196"
FT TOPO_DOM 1..32
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..68
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:P60059"
FT MOD_RES 18
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P60059"
SQ SEQUENCE 68 AA; 7741 MW; 14C8279A22548561 CRC64;
MDQVMQFVEP SRQFVKDSIR LVKRCTKPDR KEFQKIAMAT AIGFAIMGFI GFFVKLIHIP
INNIIVGG
