SC6A8_RABIT
ID SC6A8_RABIT Reviewed; 635 AA.
AC P31661;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Sodium- and chloride-dependent creatine transporter 1;
DE Short=CT1;
DE Short=Creatine transporter 1;
DE AltName: Full=Solute carrier family 6 member 8;
GN Name=SLC6A8;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain, and Muscle;
RX PubMed=8473283; DOI=10.1016/s0021-9258(18)52891-x;
RA Guimbal C., Kilimann M.W.;
RT "A Na(+)-dependent creatine transporter in rabbit brain, muscle, heart, and
RT kidney. cDNA cloning and functional expression.";
RL J. Biol. Chem. 268:8418-8421(1993).
CC -!- FUNCTION: Required for the uptake of creatine. Plays an important role
CC in supplying creatine to the brain via the blood-brain barrier (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Prominent in kidney, heart, and muscle, also
CC present in brain, but not in liver and intestine.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. SLC6A8 subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X67252; CAA47674.1; -; mRNA.
DR PIR; A46061; A46061.
DR RefSeq; NP_001075866.1; NM_001082397.1.
DR AlphaFoldDB; P31661; -.
DR SMR; P31661; -.
DR STRING; 9986.ENSOCUP00000015649; -.
DR TCDB; 2.A.22.3.4; the neurotransmitter:sodium symporter (nss) family.
DR GeneID; 100009280; -.
DR KEGG; ocu:100009280; -.
DR CTD; 6535; -.
DR eggNOG; KOG3660; Eukaryota.
DR InParanoid; P31661; -.
DR OrthoDB; 250396at2759; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0005309; F:creatine:sodium symporter activity; IEA:InterPro.
DR GO; GO:0015881; P:creatine transmembrane transport; ISS:UniProtKB.
DR GO; GO:0006836; P:neurotransmitter transport; IEA:InterPro.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR002984; Na/ntran_symport_creatine.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616; PTHR11616; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR01199; CRTTRANSPORT.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SSF161070; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome;
KW Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..635
FT /note="Sodium- and chloride-dependent creatine transporter
FT 1"
FT /id="PRO_0000214776"
FT TOPO_DOM 1..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..87
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..230
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..269
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..304
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 326..341
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 363..394
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 416..444
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 466..479
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 501..520
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 521..541
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 542..560
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 561..581
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 582..635
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 617
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P48029"
FT MOD_RES 620
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P48029"
FT MOD_RES 623
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8VBW1"
FT CARBOHYD 192
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 197
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 548
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 635 AA; 70484 MW; 3ACA6FF073396E43 CRC64;
MAKKSAENGI YSVSGDEKKG PLIAPGPDGA PAKGDGPAGL GAPGGCLAVP PRETWTRQMD
FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYVLIALV GGIPIFFLEI SLGQFMKAGS
INVWNICPLF KGLGYASMVI VFYCNTYYIM VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD
CVEIFRHEDC ANGSLANLTC DQLAERRSPV IEFWENKVLR LSGGLEVPGA LNSEVTLCLL
ACWVLVYFCV WKGVKSTGKI VYFTATFPYV VLVVLLVRGV LLPGALDGII YYLKPDWSKL
RSPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG TSFFAGFVVF
SILGFMATEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP LWAALFFFML LLLGLDSQFV
GVEGFITGLL DLLPASYYFR FQREISVALC CALCFVIDLS MVQMAGMYVF QLFDYYSASG
TTLLWQAFWE CVAVAWVYGA DRFMDDIACM IGYRPCPWMK WCWSFFTPLV CMGIFIFNIV
YYKPLVYNKT YVYPWWGEAM GWAFALSSML CVPLHLLGCL LRAKGTMAER WQHLTQPVWG
LHHLEYRAQD ADVRGLTTLT PVSESSKVVV VESVM
