ID   SC6A8_TORMA             Reviewed;         611 AA.
AC   Q91502;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Creatine transporter;
OS   Torpedo marmorata (Marbled electric ray).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Batoidea; Torpediniformes; Torpedinidae; Torpedo.
OX   NCBI_TaxID=7788;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Electric lobe;
RX   PubMed=8057375; DOI=10.1006/jmbi.1994.1507;
RA   Guimbal C., Kilimann M.W.;
RT   "A creatine transporter cDNA from Torpedo illustrates structure/function
RT   relationships in the GABA/noradrenaline transporter family.";
RL   J. Mol. Biol. 241:317-324(1994).
CC   -!- FUNCTION: Required for the uptake of creatine.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC       2.A.22) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X77306; CAA54512.1; -; mRNA.
DR   PIR; S46260; S46260.
DR   AlphaFoldDB; Q91502; -.
DR   SMR; Q91502; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000175; Na/ntran_symport.
DR   InterPro; IPR037272; SNS_sf.
DR   PANTHER; PTHR11616; PTHR11616; 1.
DR   Pfam; PF00209; SNF; 1.
DR   PRINTS; PR00176; NANEUSMPORT.
DR   SUPFAM; SSF161070; SSF161070; 1.
DR   PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR   PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR   PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Ion transport; Membrane; Sodium; Sodium transport; Symport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..611
FT                   /note="Creatine transporter"
FT                   /id="PRO_0000214778"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        66..71
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        93..122
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144..207
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        229..246
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        268..281
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        303..318
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        319..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        340..371
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        393..421
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        422..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        443..456
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        457..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        478..497
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        498..518
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        519..537
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        538..558
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        559..611
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        157
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        171
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        525
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   611 AA;  68099 MW;  DAF3DB3A5C5299AD CRC64;
     MPSRAVRRCP GHLCKEMRAP RRAQPPDVPA GEPGSRVTWS RQMDFIMSCV GFAVGLGNVW
     RFPYLCYKNG GGVFLIPYLL VAVFGGIPIF FLEISLGQFM KAGGINAWNI APLFKGLGYA
     SMVIVFFCNT YYILVLTWSS FYLVQSFSSP LPWASCNNTW NTAACYEAGA NASTEIYPPT
     APAQSSIVQF WERRVLRLSS GLGDVGEIGW ELTLCLTATW MLVYFCIWKG VKTSGKVVYV
     TATFPYIILV ILLVRGVTLH GAVQGIVYYL QPDWGKLGEA QVWIDAGTQI FFSYAIGLGT
     LTALGSYNQL HNDCYKDAFI LSLVNSATSF FAGLVVFSIL GFMAVEEGVD ISVVAESGPG
     LAFIAYPKAV TLMPFPQVWA VLFFIMLLCL GLGSQFVGVE GFVTAILDLW PSKFSFRYLR
     EVVVAMVICL SFLIDLSMIT EGGMYIFQIF DYYSASGTTL LWTAFWECVA VAWVYGGDRY
     LDDLAWMLGY RPWALVKWCW SVITPLVCMG IFTFHLVNYK PLTYNKTYTY PWWGEAIGWC
     LALASMLCVP TTVLYSLSRG RGSLKERWRK LTTPVWASHH LAYKMAGAKI NQPCEGVVSC
     EEKVVIFESV L