SCA1_RICFE
ID SCA1_RICFE Reviewed; 1703 AA.
AC Q4UNI5; Q20DN4;
DT 14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Putative surface cell antigen sca1;
DE Flags: Precursor;
GN Name=sca1; OrderedLocusNames=RF_0022;
OS Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX NCBI_TaxID=315456;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-1525 / URRWXCal2;
RX PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E.,
RA Parinello H., Claverie J.-M., Raoult D.;
RT "The genome sequence of Rickettsia felis identifies the first putative
RT conjugative plasmid in an obligate intracellular parasite.";
RL PLoS Biol. 3:1-12(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1430-1591, AND TRANSCRIPTION.
RC STRAIN=ATCC VR-1525 / URRWXCal2;
RX PubMed=16504018; DOI=10.1186/1471-2180-6-12;
RA Ngwamidiba M., Blanc G., Raoult D., Fournier P.-E.;
RT "Sca1, a previously undescribed paralog from autotransporter protein-
RT encoding genes in Rickettsia species.";
RL BMC Microbiol. 6:12-12(2006).
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}.
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DR EMBL; CP000053; AAY60873.1; -; Genomic_DNA.
DR EMBL; DQ306907; ABC41077.1; -; Genomic_DNA.
DR RefSeq; WP_011270379.1; NC_007109.1.
DR AlphaFoldDB; Q4UNI5; -.
DR STRING; 315456.RF_0022; -.
DR PRIDE; Q4UNI5; -.
DR EnsemblBacteria; AAY60873; AAY60873; RF_0022.
DR KEGG; rfe:RF_0022; -.
DR eggNOG; COG1196; Bacteria.
DR eggNOG; COG4625; Bacteria.
DR HOGENOM; CLU_002510_0_0_5; -.
DR OMA; KTTYSYG; -.
DR Proteomes; UP000008548; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.40.128.130; -; 1.
DR InterPro; IPR005546; Autotransporte_beta.
DR InterPro; IPR036709; Autotransporte_beta_dom_sf.
DR InterPro; IPR006315; OM_autotransptr_brl.
DR Pfam; PF03797; Autotransporter; 1.
DR SMART; SM00869; Autotransporter; 1.
DR SUPFAM; SSF103515; SSF103515; 1.
DR TIGRFAMs; TIGR01414; autotrans_barl; 1.
DR PROSITE; PS51208; AUTOTRANSPORTER; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Membrane; Signal; Transmembrane;
KW Transmembrane beta strand.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..1703
FT /note="Putative surface cell antigen sca1"
FT /id="PRO_0000259743"
FT DOMAIN 1419..1703
FT /note="Autotransporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00556"
FT REGION 93..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1146..1169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1284..1305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1703 AA; 188879 MW; DD34C843ED76C7AB CRC64;
MNKLTEQNLL KKSRFLKYSL LASISVGAII AIPFEGMASS KQKALFQNAL EKKLSLRLSQ
SNGNRDTTNT PQQIGTVIVP EPERNTYTSS EIREMEISKQ SKASNPLKDI PIEDHYKKVA
RSKSDVGKAR KVRPPTRSKT FVDTEKVEQN QNNYTHEPTE QTPQKPEIII TASSPTVSPA
SNGFVTAPNT PNTTLTSPEH YTTAPGTPST PVTPYQPTPD SKPNDNLEAK TPPNTNSKAV
RRLSFSSEPQ QTVVQPSTQA KPPVPPKPLL LSSAGVVAKK VVSNILRVNE MLGIKLAEVE
STIKNTQGKE NKKPLQQLKK QIASSQKTTE KLKSEAAKIG IKIKELDEEN KSLKTGRVKN
KRELDKDNAK LKENNKKIDK LQQKLTNKNN EANRLSEEID ISVKKVVLIK PQVKAPVTEM
PPAGSFLNQQ QQLEVLTQQQ KVNAARQAVV DKKRAEANGV KRNSAEYKDL ISEREEIQLE
QNQRHIAVEK TKKQQQAEDK EQRQEAQKQL SKIKKQEKAI KAASDEAQKI LNDAKKEASR
TKLKKLQEQM DNHVAMVTND KIEENIKKLE GLALTPSTTS SAATISKQSL TAKSTMQLSH
ELQRTLPEDE DGYLEPIKVQ QQPYTVMLSN QEVADPKSMD SGLGSLPSGI ETDEDTEFNL
GWGNGHHKEL ILSVDSKLIE KAAQLISGLD VKRSEILQTT SPSQQKSLNL ALQGIENDYQ
EAIEVYQGLQ QALIHKSEDI KAYNAEAEKR LDAIKSRADK YFNNIETDAD VGFNQDWSNV
HTQTAQSDSV LKMQQALLEK RSKEGSNPNF TTYLDPQPGE EGLKSIDSGL GSLPIDASVI
PQYVEELNNL ASFSSLNQIQ QKKPLIITNM LLSETSALSD DEFRAVANEV HPKIRPILTY
NRQKEKEAKL VEAEAAHSQV VQNAIKTPNS TQAKEAVENA AKLFGQYNNS FKLTQALRDE
HRKKYYETPK KVTDSINSLD LAVPAESQQL KEPRSKSLEA LDLAGSVSSQ LKQAEYKSVL
SPSSSVNSLL SNEDEQNHEF EIPKSLSFSF GSLNSDAESQ QLKEPRSKSL EALDLAGSVS
SQLKQAEYKS VLSPSSSVNS LFSNEDEQNH EFEILKSLSF SFGSLNSDAE SNLSWDNTGD
IGVGHRYGAE DSCPTPDQSS SKIANSSDKN SSETKLALLR TYQMAVIVKR QELEQLPSTS
SGADQNTQKI KELKEVEVTM HDAINACIAD SSKLNDVSFE EINEALKKLG SEIPESAISD
FESKAQKDPE AILDGSILQE MLSSKDSLPS GDEEQEDTEV TESGIQKAGD KGLLALPVSS
NECALALSDG REKECLALGD GSEEKEETIE QLSDSVEGNL KIEQEEKKEM QTQISKNAPT
LNQAKVVNTI VNNMIRNRLD ASMNMSNNMV AVGAGDEEES RIKRGLWMRG MYGTNNHGRV
ENMTGYRGTN KGATIGFDVE IDNNILGIAY SNVHSVFKFK NSKNNDKELI DSHVVSIYGQ
KELPRNFALQ ALVSASKNFI KDKTTYSYGD TKIRSNVKHS NHSYNAEALL NYNYLLQNKL
VITPNIGLRY GKSRDGVYNE TGINVQEIAL TMKENNILSG IVGTKVKVPL KDVLKFNNLG
LTFQGAVEHN FKEKTQRINR VVKIFDTEFK QNYAIPKQPK TSYNLGTGII GSIKNTTISL
DYNYYLNKHY RSHQGSVKLK VNL
