ID   SCA2_RICCN              Reviewed;        1795 AA.
AC   Q92JF7;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Putative surface cell antigen sca2;
DE   Flags: Precursor;
GN   Name=sca2; OrderedLocusNames=RC0110;
OS   Rickettsia conorii (strain ATCC VR-613 / Malish 7).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=272944;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-613 / Malish 7;
RX   PubMed=11557893; DOI=10.1126/science.1061471;
RA   Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA   Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.;
RT   "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL   Science 293:2093-2098(2001).
RN   [2]
RP   IDENTIFICATION AT TRANSCRIPTIONAL LEVEL.
RC   STRAIN=ATCC VR-613 / Malish 7;
RX   PubMed=16481498; DOI=10.1196/annals.1355.015;
RA   Ngwamidiba M., Blanc G., Ogata H., Raoult D., Fournier P.-E.;
RT   "Phylogenetic study of Rickettsia species using sequences of the
RT   autotransporter protein-encoding gene sca2.";
RL   Ann. N. Y. Acad. Sci. 1063:94-99(2005).
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}.
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DR   EMBL; AE006914; AAL02648.1; -; Genomic_DNA.
DR   PIR; F97713; F97713.
DR   PDB; 4J7O; X-ray; 2.18 A; A=34-400.
DR   PDBsum; 4J7O; -.
DR   AlphaFoldDB; Q92JF7; -.
DR   SMR; Q92JF7; -.
DR   PRIDE; Q92JF7; -.
DR   EnsemblBacteria; AAL02648; AAL02648; RC0110.
DR   KEGG; rco:RC0110; -.
DR   HOGENOM; CLU_238220_0_0_5; -.
DR   OMA; DFIGPRT; -.
DR   Proteomes; UP000000816; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.130; -; 1.
DR   InterPro; IPR005546; Autotransporte_beta.
DR   InterPro; IPR036709; Autotransporte_beta_dom_sf.
DR   Pfam; PF03797; Autotransporter; 1.
DR   SMART; SM00869; Autotransporter; 1.
DR   SUPFAM; SSF103515; SSF103515; 1.
DR   PROSITE; PS51208; AUTOTRANSPORTER; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell outer membrane; Membrane; Signal; Transmembrane;
KW   Transmembrane beta strand.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..1795
FT                   /note="Putative surface cell antigen sca2"
FT                   /id="PRO_0000262569"
FT   DOMAIN          1516..1795
FT                   /note="Autotransporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00556"
FT   REGION          360..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          664..709
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1354..1441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        671..697
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1354..1381
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1382..1397
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1398..1415
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1421..1435
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   HELIX           36..41
FT                   /evidence="ECO:0007829|PDB:4J7O"
FT   HELIX           44..46
FT                   /evidence="ECO:0007829|PDB:4J7O"
FT   HELIX           51..60
FT                   /evidence="ECO:0007829|PDB:4J7O"
FT   HELIX           63..72
FT                   /evidence="ECO:0007829|PDB:4J7O"
FT   HELIX           79..86
FT                   /evidence="ECO:0007829|PDB:4J7O"
FT   HELIX           92..96
FT                   /evidence="ECO:0007829|PDB:4J7O"
FT   HELIX           100..121
FT                   /evidence="ECO:0007829|PDB:4J7O"
FT   HELIX           125..135
FT                   /evidence="ECO:0007829|PDB:4J7O"
FT   HELIX           141..147
FT                   /evidence="ECO:0007829|PDB:4J7O"
FT   HELIX           154..156
FT                   /evidence="ECO:0007829|PDB:4J7O"
FT   TURN            159..161
FT                   /evidence="ECO:0007829|PDB:4J7O"
FT   HELIX           165..196
FT                   /evidence="ECO:0007829|PDB:4J7O"
FT   HELIX           203..210
FT                   /evidence="ECO:0007829|PDB:4J7O"
FT   HELIX           214..238
FT                   /evidence="ECO:0007829|PDB:4J7O"
FT   HELIX           245..252
FT                   /evidence="ECO:0007829|PDB:4J7O"
FT   HELIX           260..281
FT                   /evidence="ECO:0007829|PDB:4J7O"
FT   HELIX           288..295
FT                   /evidence="ECO:0007829|PDB:4J7O"
FT   HELIX           299..323
FT                   /evidence="ECO:0007829|PDB:4J7O"
FT   HELIX           330..337
FT                   /evidence="ECO:0007829|PDB:4J7O"
FT   HELIX           341..360
FT                   /evidence="ECO:0007829|PDB:4J7O"
SQ   SEQUENCE   1795 AA;  203997 MW;  BC8AE9FDC2D03A16 CRC64;
     MNLQNSHSKK YVLTFFMSTC LLTSSFLSTS ARAASFKDLV SKTPAWEKHN STQQQNIWKD
     LTPNEKIKKW QEAALVPSFT QAQNDLGIKY KETDLSSFLD NTRHKARQAR AEILLYIERV
     KQQDFDTKKQ AYINQGVVPT DIEAATNLGI SYDPSKIDNN VEHDQKVRRA EKDKKAVIEL
     YVSSINRGIK YKHYVDNDII PEIQEVRTAL NMNKDDAQSF VASIRTEIME NAKGQYIADS
     HIPTEKELKK KFGISRDDNR DGYIKSIRLK VMDKEKPQYI ADSHIPTEKE LEQKFGADKG
     EATNYIASIA TQMMLDKKSY YIDNNIIPNA DELMNEFKIG PVKATSYINQ IRAGIEANQF
     LNNNDTTKPS TGRSQKKSGS KNDHWYMSNQ SINNTGTSAR IVTGREKKQR YFFDPISTFK
     TYFNTKASKG NLTQSQHNIN RIIQQEENIE EFKNLIKTDP IAALTLQVDS SYKQEAVTTI
     LSDFNDDTIQ RVLFSNDKGK LDFNTNIDVK NRPILQELLE NSSSEEKTKF AERIQDYATR
     NISNSQFEEK ARLDLIKLAA SKDKSSVENF LTLQLELKNR MQPYVVNSVY ILTPEIVKEI
     NIELKNKGLI RDSLTKDYMI KLAKEVNNHT LNSVIKVILS DSKILSNETN KILGLAVSNN
     ANNLEQTQSG IPNPPPLPLN GGIPNPPPLP LNGSMPPPPL HSQGFSSNSK HFDLNQLQTE
     YPHIHSLYVQ FTHNTTVQSK APLQPTASSA TSTGRSTPET AYAKLYAEYR TETGGTKAND
     LQDQLIKRQA DLTNVIRQIL TESYANQGAD EKTLLNLFSI STPEIAEKAK EAFNTLAQDQ
     YIKDITVNGK KTITSEEIIK NLFNEDTDDA IKRILLSSCK ISEELKRPIK LEFNKSELIR
     ELQGKQNPFK QLEFAYINTK NFDQDIFGNR IDELINNPNI LTIVQQATFL TKEDTNLRKT
     INSDQAQAKL DDLRTAILST IKIEELITAN LPQHDFIAIV KEKDPELLKE FLKATTLTVT
     GNNNLDQLRL ALPSFTGMSN EQIRILSNKL KMSIILKALK ECSQEKATQY IHTGNMPPPP
     PPPPPLPDSQ DLELAYLKSL GITKANTSTF KTTPKTYHFS SDIALRYKEF TLSGQKSAGY
     KAKYSDADLL KKAIVESVAF EHSKNLSKAH QNNKYFEQIQ KAVNTMYSSF IGHRTELEQK
     IHNIYTSKLL ELTKDKEFIK YVEDNIILNK KLTKAFTSAD SDFIDSRTEL EQKIHNIYIQ
     QLTKYPEEEV KEAFNTASLD FIGPRTEIGQ EVHNIYKSQL LELTKDTELC LFTQQVLAEA
     TELEQKYGSD IQSENSNNEK KVERLDQEKL QLFKQENEAT NDESSTKDDT QPEDSNKKSE
     QSDSKTALSP RLLSSNDSKN DKSSDDKKSL LALRSSDEDD TGYATDEEEL EESNSTTDEE
     LKKDVVLESE DEAIDVSFKT EAITEQDEVT QRQQVSDDTS GKVAILVQAT STLHKPVHYN
     INDRLTVAAI GAGDEETSIN RGVWISGLYG INKQRIWKNI PKYQNRTTGI TIGTDAEFIN
     SHDVIGIAYS RLESQIKYNK KLGKTTVNGH LLSIYSLKEL IKGFSLQTIT SYGHNYIKNR
     SKNINNIIGK YQNNSLSFQT LLNYKYRTKY DLHFIPNIGF QYDYSRASNY KEYNVDIENL
     MIQKKSNQLF ESSLGGKIVF KPIVTTNNIV LTPSLYGNIE HHFNNKNTKV NAKATFKGQT
     LQETIITLKQ PKLGYNIGSN ILMSRKNINV LLEYNYYTHR KYQSHQGLIK LKVNL