ID   SCA2_RICFE              Reviewed;        1604 AA.
AC   Q4UNE0;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Putative surface cell antigen sca2;
DE   Flags: Precursor;
GN   Name=sca2; OrderedLocusNames=RF_0067;
OS   Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=315456;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16481498; DOI=10.1196/annals.1355.015;
RA   Ngwamidiba M., Blanc G., Ogata H., Raoult D., Fournier P.-E.;
RT   "Phylogenetic study of Rickettsia species using sequences of the
RT   autotransporter protein-encoding gene sca2.";
RL   Ann. N. Y. Acad. Sci. 1063:94-99(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1525 / URRWXCal2;
RX   PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA   Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E.,
RA   Parinello H., Claverie J.-M., Raoult D.;
RT   "The genome sequence of Rickettsia felis identifies the first putative
RT   conjugative plasmid in an obligate intracellular parasite.";
RL   PLoS Biol. 3:1-12(2005).
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}.
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DR   EMBL; AY355374; AAT79539.1; -; Genomic_DNA.
DR   EMBL; CP000053; AAY60918.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q4UNE0; -.
DR   SMR; Q4UNE0; -.
DR   STRING; 315456.RF_0067; -.
DR   PRIDE; Q4UNE0; -.
DR   EnsemblBacteria; AAY60918; AAY60918; RF_0067.
DR   KEGG; rfe:RF_0067; -.
DR   eggNOG; COG2188; Bacteria.
DR   eggNOG; COG3468; Bacteria.
DR   HOGENOM; CLU_238220_0_0_5; -.
DR   OMA; DFIGPRT; -.
DR   Proteomes; UP000008548; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.130; -; 1.
DR   InterPro; IPR005546; Autotransporte_beta.
DR   InterPro; IPR036709; Autotransporte_beta_dom_sf.
DR   InterPro; IPR006315; OM_autotransptr_brl.
DR   Pfam; PF03797; Autotransporter; 1.
DR   SMART; SM00869; Autotransporter; 1.
DR   SUPFAM; SSF103515; SSF103515; 1.
DR   TIGRFAMs; TIGR01414; autotrans_barl; 1.
DR   PROSITE; PS51208; AUTOTRANSPORTER; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Signal; Transmembrane;
KW   Transmembrane beta strand.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..1604
FT                   /note="Putative surface cell antigen sca2"
FT                   /id="PRO_0000262570"
FT   DOMAIN          1325..1604
FT                   /note="Autotransporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00556"
FT   REGION          324..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          554..603
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1183..1240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        324..345
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        567..590
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1190..1214
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1604 AA;  182803 MW;  AEDF32AE861BB416 CRC64;
     MSLQNSHSKK YVLTFFMSTC LLTSSFLSTS ARAASFTQLA NQIPTLSGLS EVQRKQKWNS
     YTLQEKQEAW RRAKLTPDFV QAMIDMQTGF TESDLSSRNN KTRHKAREKK SELDLYIAGT
     KQGFKEKVDG YISQGKIPTP EEAAQNLEID YDAKKTDNKL EKNQNVRRVE KDKKALLDLY
     IHSITTSVKE KEYITTGQVP ELGELEKALN ISKEEAKHRR TIIRDQVMAN ERPKLVRSGT
     VLTKKELHKR FGKDTTTDDT KYIDDITTEV MYTKKQGYVN TDFLPKISEI MNEFKVDKGR
     ANLYLNQIKA GIEAKLLADN NQTTTKPFTK HSRTTTNTAG ISSGVPFDTG RTKPETKSFD
     FKRSMYSLLN RKQEDQLSKT EQHLKQQIKL EENKEEFKEI LTKNPIDALL FAEQSNLGNS
     FKQEAISNID LSKDISRILF TVDDKGNRTI LNTILTTTPE HKDELIKQAQ HHAIQTLPTS
     ISDKDVSDKK KLTLATLAAT EDKKVLEEAL DNWLSTNGYK RKPEVESLIS ILLSDETTLK
     AGIDKIFELP VENNVNNNSN KGQNGTPILP PTPPLNGSMP PSPPPPLLNG TPTSTAFNNS
     NPNHKFDLKN FEATYPRLYK SYNEFIQNTT SASQSQATTT SNNIPDTKAK MGESLELLKQ
     KVAKQNEVIG LIHNEVTKLY NFSPKTFVNL FNTENEEIIK KIEQIAKRED IQKILQDNDI
     KITSTFVSKI FNESLEQTKQ RLRSSNIINA KQYKRIEQYA NKQECVTEFL RITNPLEQLK
     FANKYINILG QSTFNGKLNE LIENPNKLTF SQKINFVLQG YQELTREIPT AKANLNKLKQ
     NILEKIEIQQ LIANKDISRK DLLDILNNKN PELLKSLLEA KVILEENKLN NSANEVDLKE
     IIPSLNYLTS EQLTSLINRI TIEGVKTALK AKWQQENKTV SNNTEKPLIY NNGTPMPPPI
     PNGNSNFGTN DYLISMGYTQ EFIDRMDKVK PNNNFGKNHN YTATDFKSNV GKNYYESTSK
     LGGTDILLTD SQKLENAIKK EVLAKYIEEP NRDMQDDSLL KQAFEEKFYY AEDKNTKVIP
     KPSEVNFDPN FIGPRTEVGQ EIYELYEQEL LKLARDPVFI EYVKNNNNTQ KDERELLISF
     IEQIESKRPE LEQKYGSDVQ SEDNNQEKKV GHLNMKQFQS LFQQENESAN DESSTKDDPQ
     PEDSNKKSEK SDSETALSPR LLSSNDSKND KSSDDKKSLL VLRSSEEESK KDIALESEDE
     AIDMSFKTEA IAEQDEATQR QQVSDDTNRK VAILVKATST LHKPVHYNIL SDRLKVAAIG
     AGDEEASINR GVWISGLYGI NKQGTWKNIP KYQGRTTGVT IGADAEFINS HDVIGIAYSR
     LEFQIKYNKK LEKTAVNGHL LSIYGLKELI KGFSLQAITS YGHNYIKNKS KSINNIIGKY
     QNNNLSFQTL LNYKYRTKYD LHFIPNIGFK YDYSRASNYK EYNVDIENLM NQKKSNQSFE
     SSIGGKIVFK PIATVNNIIL TPSLYGNIER HFNNKNTKVN AKATFKGQTL QETIIIPKQP
     KLGYNIGSNI LMSKKNINVL LEYNYYTHRK YQSHQGLIKL KVNL