ID   SCA2_RICS2              Reviewed;        1812 AA.
AC   Q3L8P3;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Putative surface cell antigen sca2;
DE   Flags: Precursor;
GN   Name=sca2;
OS   Rickettsia sibirica (strain ATCC VR-151 / 246).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group;
OC   Rickettsia sibirica subgroup.
OX   NCBI_TaxID=272951;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC VR-151 / 246;
RX   PubMed=16481498; DOI=10.1196/annals.1355.015;
RA   Ngwamidiba M., Blanc G., Ogata H., Raoult D., Fournier P.-E.;
RT   "Phylogenetic study of Rickettsia species using sequences of the
RT   autotransporter protein-encoding gene sca2.";
RL   Ann. N. Y. Acad. Sci. 1063:94-99(2005).
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}.
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DR   EMBL; AY355384; AAT79548.1; -; Genomic_DNA.
DR   RefSeq; WP_004996770.1; NZ_AABW01000001.1.
DR   AlphaFoldDB; Q3L8P3; -.
DR   SMR; Q3L8P3; -.
DR   STRING; 272951.rsib_orf602; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.130; -; 1.
DR   InterPro; IPR005546; Autotransporte_beta.
DR   InterPro; IPR036709; Autotransporte_beta_dom_sf.
DR   Pfam; PF03797; Autotransporter; 1.
DR   SMART; SM00869; Autotransporter; 1.
DR   SUPFAM; SSF103515; SSF103515; 1.
DR   PROSITE; PS51208; AUTOTRANSPORTER; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Signal; Transmembrane;
KW   Transmembrane beta strand.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..1812
FT                   /note="Putative surface cell antigen sca2"
FT                   /id="PRO_0000262571"
FT   DOMAIN          1533..1812
FT                   /note="Autotransporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00556"
FT   REGION          344..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          648..691
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1338..1462
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        655..687
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1338..1365
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1366..1381
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1382..1399
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1405..1444
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1812 AA;  205565 MW;  0F7025C812987BAE CRC64;
     MSTCLLTSSF LSTSARAASF KDLVSKTPAW EKHNSTQQQN IWKDLTPNEK IKKWQEAALV
     PSFTQAQNDL GIKYKETDLS SFLDNTRHKA RQARAEILLY IERVKQQDFD TKKQEYINQG
     VVPTDIEAAT NLGISYDPSK IDNNVEHDQK VRRAEKDKKA VIELYISSIN RDIKYKHYVD
     NDIIPEMQEV RTALNMNKDE AQSFVASIRT EIMENAKGQY IADSHIPTEK ELKKKFGISR
     DDNRDGYIKS IRLKVMDKEK PQYIADSHIP TEKELEQKFG ADKGEATNYI ASIATQMMLG
     KKSYYIDNNI IPNADELMNE FKIGPVKTAS YINQIRAGIE ANQFLNNNDT TKPSTGRSQK
     KSGSKNDHWY MSNQSIHNTG TSSRIFTGRE KKQRYFFDPI STFKTHFNTK ANKGNLTQSQ
     HSINRIIQQE ENIEEFKNLI KTDPIIALTL QVDSSYKQEA VTTILSDFND DTIQRVLFSN
     DKGQLDFNTN IDVKNRPILQ ELLENSSSEE KTKFAERIQD YATRNISNSQ FEEKARLDLI
     KLAASKDKSS VENFLTLQLE LKNIMQPYIV NSVYILTPEI VKEINIELKN KGLIRDSLTK
     DYMIKLAKEV SNHTLNSVIK VILSDSNILS NETNKILGLA VGNNANNLEQ TQSGIPNPPP
     LPLNGGIPNP PPLPLNGSMP PPPPLHSQGF SSNSKHFDLN QLQTEYPHIH SLYIQFTHNT
     TVQSKAPLQP TASSATSTVR STPETAYAKL YAEYRTETGG TKANDLQDQL IKRQADLTNV
     IRQILTESYA NQGADEKTLL NLFSISTPEI AEKAKEAFNT LAQDQYIKDI TVNGKKTITS
     EEIIKNLFNE DTDDAVKRIL LSSCKISEEL KRPIKLQFNQ SELIRELQGK QNPFEQLEFA
     YINAKNFDQD IFGNRVDELI NNPNILTIVQ QATFLITEDT NLRKTINSDQ AQAKLDDLRT
     AILSTIKFEE LITANLPQHD FIAIVKEKDP ELLKEFLKAT TLKVTGNNNL DQLRLALPSF
     KGMSNEQIRI LSNKLKMPII LKALKECSQE KATKYIHTGN MPPPPPPLPD SQDLELAYLT
     SLGITKFNAN TSTLKTTPKT YHFSSDIALR YKEFTLSGQK SAGYKAKYSD ADLLKKAIVE
     SVAFEHSKNL SKAHQNNKYF EQIQEAVDTM YSSFIGPRTE IGQKIHNIYT SKLLELTKDK
     EFIKYVEDNI ILSKKLTEAF TSADSDFIDS RTGLGQKIHD IYIQQLTKYP EEEVKEAFNT
     ANPDFIGPRT EIGQEVHNIY KSQLLELTKD QELSLFTQQV LAESTELERK YGSDIQSGNS
     NNEKKVGRLD QEKLQSFKQE NEATNDASST KDDTQPEDSN KKSEQSDSKT ALSPRLLSSN
     DSKNDKSSDD KKSLLALRSS DEDDTGYATD EEELEESNST TNEELEESNS TTNEELEESN
     STTNEELEES NSTTNEELKK DVVLESEDEA IDVSFKTEAI TEQDEVTQRQ QISDDTSGKV
     AILVQATSTL HKPVHYNIND RLTVAAIGAG DEETSINRGV WISGLYGINK QRIWKNIPKY
     QNRTTGITIG IDAEFINSHD VIGIAYSRLE SQIKYNKKLG KTTVNGHLLS IYSLKELIKG
     FSLQTITSYG HNYIKNRSKN INNIIGKYQN NNLSFQTLLN YKYRTKYDLH FIPNIGFQYD
     YSRASNYKEY NVDIENLMIQ KKSNQLFESS LGGKIVFKPI VTTNNIVLTP SLYGNIEHHF
     NNKNTKVNAK ATFKGQTLQE TIITLKQPKL GYNIGSNILM SRKNINVLLE YNYYTHRKYQ
     SHQGLIKLKV NL