ID   SCA4_RICTY              Reviewed;        1019 AA.
AC   Q9AJ63; Q68WN5;
DT   11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT   09-NOV-2004, sequence version 2.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Antigenic heat-stable 120 kDa protein;
DE   AltName: Full=120 kDa antigen;
DE   AltName: Full=Protein PS 120;
DE            Short=PS120;
GN   Name=sca4; Synonyms=D; OrderedLocusNames=RT0485;
OS   Rickettsia typhi (strain ATCC VR-144 / Wilmington).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=257363;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-144 / Wilmington;
RX   PubMed=15317790; DOI=10.1128/jb.186.17.5842-5855.2004;
RA   McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E.,
RA   McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E.,
RA   Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A., Hong C.,
RA   Yu X.-J., Walker D.H., Weinstock G.M.;
RT   "Complete genome sequence of Rickettsia typhi and comparison with sequences
RT   of other Rickettsiae.";
RL   J. Bacteriol. 186:5842-5855(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-1005.
RX   PubMed=11491333; DOI=10.1099/00207713-51-4-1353;
RA   Sekeyova Z., Roux V., Raoult D.;
RT   "Phylogeny of Rickettsia spp. inferred by comparing sequences of 'gene D',
RT   which encodes an intracytoplasmic protein.";
RL   Int. J. Syst. Evol. Microbiol. 51:1353-1360(2001).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
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DR   EMBL; AE017197; AAU03957.1; -; Genomic_DNA.
DR   EMBL; AF188482; AAK31303.1; -; Genomic_DNA.
DR   RefSeq; WP_011190939.1; NC_006142.1.
DR   AlphaFoldDB; Q9AJ63; -.
DR   SMR; Q9AJ63; -.
DR   STRING; 257363.RT0485; -.
DR   EnsemblBacteria; AAU03957; AAU03957; RT0485.
DR   KEGG; rty:RT0485; -.
DR   eggNOG; COG5183; Bacteria.
DR   HOGENOM; CLU_009206_0_0_5; -.
DR   OMA; TAHYEEG; -.
DR   OrthoDB; 92202at2; -.
DR   Proteomes; UP000000604; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR020954; Rickettsia_antigen_120kDa.
DR   Pfam; PF12574; 120_Rick_ant; 1.
PE   4: Predicted;
KW   Cytoplasm.
FT   CHAIN           1..1019
FT                   /note="Antigenic heat-stable 120 kDa protein"
FT                   /id="PRO_0000097619"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        15
FT                   /note="L -> V (in Ref. 2; AAK31303)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        168
FT                   /note="Q -> K (in Ref. 2; AAK31303)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        175
FT                   /note="Q -> H (in Ref. 2; AAK31303)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        179
FT                   /note="S -> N (in Ref. 2; AAK31303)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        183
FT                   /note="S -> A (in Ref. 2; AAK31303)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        192
FT                   /note="E -> D (in Ref. 2; AAK31303)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        202..209
FT                   /note="IKTNSLIV -> VKTKPFTL (in Ref. 2; AAK31303)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        220
FT                   /note="N -> S (in Ref. 2; AAK31303)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        605
FT                   /note="E -> G (in Ref. 2; AAK31303)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        615
FT                   /note="D -> H (in Ref. 2; AAK31303)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        976
FT                   /note="E -> VE (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1005
FT                   /note="N -> P (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1019 AA;  113828 MW;  02729DD08C014886 CRC64;
     MSKNDNQDIS EFDPLNREFT EAEKQQQMQQ EQEFFSQSIL DIVDDGFIVA SSSQSTPSIS
     VLSNSLPHGD QKSDPITEAI RKEILEKQRD ILREYLANTN PELAAQIAKE EDDKKFRAFL
     SNQDNYALIN KAFEDPETKK NLEEVEIVGY RNILSTYSAA SGYPGGFQPV QWENQVSASD
     LRSTVVKNDA GEELCTLNET TIKTNSLIVA KQDGTQVQIN SYREIDFPIK LDKADGSMHL
     SMVALKADGT KPAKDKAVYF TAHYEEGPNG KPQLKEISSP QPLKFVGTGD DAVAYIEHGG
     EIYTLAVTRG KYKAMMKEVA LNNGQSVDLS QTIAEDLTKV QGPSHVRHTP IITPNQELEL
     SIETHSNQQV PPITTFNKPL QPEISQTHQL QPQQAQSSGI PNLVLNAAHA LSISMQDLLH
     NINASLTQKQ DINKQSDLIK EAANTILNNK KSDFAEKQYN IIALTENTLS NKDIIADAKV
     NVVSALLETI QNDQNTLDIQ KSKILEATVA ITLNSENIEL KQKQQILEKV VDVSLSIKDD
     ISRAVAIDSI TDAVIKSNIA NKDKEQIFMT IFDQVNSYEF SNITKQKLLG SMLKKAVETK
     VISPEQQQLI HQNLDKITTE HTKRDTIEKV NNILLDPFSN TVLKTTNIQV ITANVLDSPV
     PVEIKSELIQ VVTQKVAESA LEPKDKTEIV KGIGKIIATH SDTSLPLYDK GVIMESVAKG
     IVESKTDLRE RELITEGLVN GIYEVKGDKA VVHAISSVIA NSNINQSEKE VLKKSQDIVS
     ERVLDKEIQN LDGELKEKNI EESKLRDDIY NKTQDVANEL NIKTFLDDNH GKREVSEEVP
     KNTSSLLNDI SQRTIEKVNN LRAMLSQDAN LKTFEEKKDE STKKVDELVK AFDNKSSTEE
     QQNFIKSHLI DNKTLSREVR LQIIDNLLKA QAQKRAETIE NLSAKTEDVR VVSGKSELEP
     ISKDEPYIQK AKMVVERDRV GIKDNIKIMG ALINARDSIQ SENLNKSTHI KKESSVPQR