ID   SCAI_DICDI              Reviewed;         773 AA.
AC   Q54YY1;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Protein SCAI homolog;
GN   Name=scai; ORFNames=DDB_G0278015;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May function as a transcriptional cofactor with a repressor
CC       activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SCAI family. {ECO:0000305}.
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DR   EMBL; AAFI02000023; EAL68180.1; -; Genomic_DNA.
DR   RefSeq; XP_642071.1; XM_636979.1.
DR   AlphaFoldDB; Q54YY1; -.
DR   STRING; 44689.DDB0304444; -.
DR   PaxDb; Q54YY1; -.
DR   EnsemblProtists; EAL68180; EAL68180; DDB_G0278015.
DR   GeneID; 8621284; -.
DR   KEGG; ddi:DDB_G0278015; -.
DR   dictyBase; DDB_G0278015; -.
DR   eggNOG; ENOG502QPT4; Eukaryota.
DR   HOGENOM; CLU_020095_2_1_1; -.
DR   InParanoid; Q54YY1; -.
DR   OMA; MGYDLGG; -.
DR   PhylomeDB; Q54YY1; -.
DR   PRO; PR:Q54YY1; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR022709; SCAI.
DR   Pfam; PF12070; SCAI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..773
FT                   /note="Protein SCAI homolog"
FT                   /id="PRO_0000356852"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          250..280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          353..408
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          513..532
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        353..404
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   773 AA;  88292 MW;  901403459A052D0A CRC64;
     MEITTKSSTT TDDLNNNNNK TVTPIKSENS ATGHTSPPNN STTTTTSSTS AQPITVLPTE
     IIKTFEHLLR KSQRLFIGLR DLPQFGRQWQ PFFQKTFELY TKLWKFQQQY RSILEDKSKY
     GLKRCEIGEI ASKIGQLYYH YYLRTSDTNY LNESYIFYEA IRLRSYFKDV SLDKTPDMMV
     KQLRYYARFI VVCLLLNKKK VVFDLIEELL KHVNDYTKIY KPSDAQEWSL VLQEIFSFLQ
     ADQCATFSDT NQSPSLTNSG NIINNNSNSN NNNGEHTNNT VQSHRLNHLN CPSPPFPLES
     TQILQQAILV GSQQNQIKFS EITLDMFRMT QSLEYEPMSE AKENDMKLKQ QLTALQQQQQ
     QQAAEAKEKN NGTDQQNTTI PSQPLQQHLH HQQQQQQNGN GSGIKKRNPH KYLLYRPTIS
     QILLFLSYSF KELGDNKAML LYICADGFTN EDNHVNQHIQ PPPSIQQETV PSLIDDSNTN
     IPITTTATAT NPLYNKLFTK GLTLNMQKPS QAINSPTVNN NNNNTTTNVT VPTTTTTATN
     VTAQTTTTTT TTNSTSTSTT SNIPIYKYNE APFNTKVESL YPMDLLPFCR KPFFLIVNSQ
     SSDIFNELPT FNQPFVSLLS PQSIPKKLVS NLKCGNLFTF FLHDPISAFC DISCGNKIPS
     KTFNNISLLA QNSLEIISKL LFECVDLHPS FSFFLLDDFL RSFIIRFIFC HATFYLHKEF
     QDNIYQVKSN PPLPKSLLYN QSILKSIHQL VSELDVSDQF LGLNENRLVI HEN