SCAM2_ARATH
ID SCAM2_ARATH Reviewed; 283 AA.
AC Q9LR68;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Secretory carrier-associated membrane protein 2;
DE Short=AtSC2;
DE Short=Secretory carrier membrane protein 2;
GN Name=SCAMP2; Synonyms=SC2; OrderedLocusNames=At1g03550; ORFNames=F21B7.17;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=10982391; DOI=10.1091/mbc.11.9.2933;
RA Hubbard C., Singleton D., Rauch M., Jayasinghe S., Cafiso D., Castle D.;
RT "The secretory carrier membrane protein family: structure and membrane
RT topology.";
RL Mol. Biol. Cell 11:2933-2947(2000).
CC -!- FUNCTION: Probably involved in membrane trafficking. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SCAMP family. {ECO:0000305}.
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DR EMBL; AC002560; AAF86532.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27585.1; -; Genomic_DNA.
DR EMBL; BT024511; ABD19692.1; -; mRNA.
DR EMBL; AY086966; AAM64529.1; -; mRNA.
DR RefSeq; NP_563686.1; NM_100237.1.
DR AlphaFoldDB; Q9LR68; -.
DR SMR; Q9LR68; -.
DR STRING; 3702.AT1G03550.1; -.
DR PaxDb; Q9LR68; -.
DR PRIDE; Q9LR68; -.
DR EnsemblPlants; AT1G03550.1; AT1G03550.1; AT1G03550.
DR GeneID; 839464; -.
DR Gramene; AT1G03550.1; AT1G03550.1; AT1G03550.
DR KEGG; ath:AT1G03550; -.
DR Araport; AT1G03550; -.
DR TAIR; locus:2020828; AT1G03550.
DR eggNOG; KOG3088; Eukaryota.
DR HOGENOM; CLU_066546_3_0_1; -.
DR InParanoid; Q9LR68; -.
DR OrthoDB; 995882at2759; -.
DR PhylomeDB; Q9LR68; -.
DR PRO; PR:Q9LR68; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LR68; baseline and differential.
DR Genevisible; Q9LR68; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055038; C:recycling endosome membrane; IBA:GO_Central.
DR GO; GO:0032588; C:trans-Golgi network membrane; IBA:GO_Central.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR InterPro; IPR007273; SCAMP.
DR PANTHER; PTHR10687; PTHR10687; 1.
DR Pfam; PF04144; SCAMP; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Coiled coil; Cytoplasmic vesicle; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..283
FT /note="Secretory carrier-associated membrane protein 2"
FT /id="PRO_0000304901"
FT TOPO_DOM 1..123
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..283
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 50..87
FT /evidence="ECO:0000255"
SQ SEQUENCE 283 AA; 31873 MW; 2AA73695A5D21D54 CRC64;
MARHDPNPFA DEEINPFANH TSVPPASNSY LKPLPPEPYD RGATVDIPLD SGNDLRAKEM
ELQAKENELK RKEQELKRRE DAIARTGVVI EEKNWPEFFP LIHHDIPNEI PIHLQKIQYV
AFTTLLGLVG CLLWNIVAVT VAWIKGEGPT IWLLSIIYFL AGVPGAYVLW YRPLYRATRT
DSALKFGAFF FFYVFHIAFC GFAAVAPPVI FQGKSLTGFL PAIELLTTNA AVGIMYFIGA
GFFCIETLLN IWVIQQVYAY FRGSGKAAEM KREATKSTLM RAL
