SCAM3_BOVIN
ID SCAM3_BOVIN Reviewed; 347 AA.
AC Q58DR5; Q3ZCL2;
DT 02-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Secretory carrier-associated membrane protein 3;
DE Short=Secretory carrier membrane protein 3;
GN Name=SCAMP3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions in post-Golgi recycling pathways. Acts as a
CC recycling carrier to the cell surface (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with NEDD4 and NEDD4L and TSG101. Interacts with
CC RNF126. {ECO:0000250|UniProtKB:O14828, ECO:0000250|UniProtKB:O35609}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- PTM: Monoubiquitinated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SCAMP family. {ECO:0000305}.
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DR EMBL; BT021532; AAX46379.1; -; mRNA.
DR EMBL; BC102055; AAI02056.1; -; mRNA.
DR RefSeq; NP_001030503.1; NM_001035426.1.
DR AlphaFoldDB; Q58DR5; -.
DR SMR; Q58DR5; -.
DR STRING; 9913.ENSBTAP00000044219; -.
DR iPTMnet; Q58DR5; -.
DR PaxDb; Q58DR5; -.
DR PRIDE; Q58DR5; -.
DR GeneID; 539670; -.
DR KEGG; bta:539670; -.
DR CTD; 10067; -.
DR eggNOG; KOG3088; Eukaryota.
DR InParanoid; Q58DR5; -.
DR OrthoDB; 995882at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR007273; SCAMP.
DR PANTHER; PTHR10687; PTHR10687; 1.
DR Pfam; PF04144; SCAMP; 1.
PE 2: Evidence at transcript level;
KW Isopeptide bond; Membrane; Phosphoprotein; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW Ubl conjugation.
FT CHAIN 1..347
FT /note="Secretory carrier-associated membrane protein 3"
FT /id="PRO_0000191256"
FT TOPO_DOM 1..170
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..67
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 32
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O14828"
FT MOD_RES 37
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O14828"
FT MOD_RES 41
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:O14828"
FT MOD_RES 53
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:O14828"
FT MOD_RES 72
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O14828"
FT MOD_RES 76
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O14828"
FT MOD_RES 83
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:O35609"
FT MOD_RES 85
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O14828"
FT CROSSLNK 313
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO1)"
FT /evidence="ECO:0000250|UniProtKB:O14828"
FT CONFLICT 121
FT /note="Q -> R (in Ref. 2; AAI02056)"
FT /evidence="ECO:0000305"
FT CONFLICT 231
FT /note="S -> F (in Ref. 2; AAI02056)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 347 AA; 38278 MW; A42981CD536E2F48 CRC64;
MAQGRDGGNP FAEPGELDNP FQDPAVIQHR PSTHYATLDV YNPFETREPP PSYEPPAPVP
IAPPSAPPLQ SSRKLSPTEP KNYGSYSTQA STAAATAELL KKQEELNRKA EELDRREREL
QHAALGSTAT RQNNWPPLPS FCPVQPCFFQ DISMEIPQEF QKTVSTMYYL WMCSTLALLL
NFLACLASFC VETSNGSGFG LSILWILLFT PCSFVCWYRP MYKAFRSDSS SNFFVFFFIF
FVQDVLFVLQ AIGIPGWGFS GWISALVVLK VNTAVAVLML LVALFFTGIA VLGIVMLKRI
HSLYRRTGAS FQKAQQEFAA GVFSNPAVRT AAANAAAGAA ENAFRAP
