SCAM4_MOUSE
ID SCAM4_MOUSE Reviewed; 230 AA.
AC Q9JKV5;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Secretory carrier-associated membrane protein 4;
DE Short=SC4;
DE Short=Secretory carrier membrane protein 4;
GN Name=Scamp4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Castle J.D., Hubbard C.H. Jr., Singleton D.R.;
RT "The SCAMP (secretory carrier membrane protein) family: structure and
RT membrane topology.";
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11050114; DOI=10.1523/jneurosci.20-21-07941.2000;
RA Fernandez-Chacon R., Suedhof T.C.;
RT "Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific
RT forms implicate SCAMPs in multiple membrane-trafficking functions.";
RL J. Neurosci. 20:7941-7950(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Probably involved in membrane protein trafficking.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the SCAMP family. {ECO:0000305}.
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DR EMBL; AF224721; AAF35368.1; -; mRNA.
DR EMBL; AF295102; AAG02502.1; -; mRNA.
DR EMBL; BC018215; AAH18215.1; -; mRNA.
DR EMBL; BC054104; AAH54104.1; -; mRNA.
DR CCDS; CCDS24028.1; -.
DR RefSeq; NP_062521.1; NM_019575.4.
DR AlphaFoldDB; Q9JKV5; -.
DR STRING; 10090.ENSMUSP00000078808; -.
DR iPTMnet; Q9JKV5; -.
DR PhosphoSitePlus; Q9JKV5; -.
DR SwissPalm; Q9JKV5; -.
DR EPD; Q9JKV5; -.
DR MaxQB; Q9JKV5; -.
DR PaxDb; Q9JKV5; -.
DR PRIDE; Q9JKV5; -.
DR ProteomicsDB; 253405; -.
DR Antibodypedia; 22844; 93 antibodies from 23 providers.
DR DNASU; 56214; -.
DR Ensembl; ENSMUST00000079883; ENSMUSP00000078808; ENSMUSG00000113949.
DR Ensembl; ENSMUST00000180350; ENSMUSP00000137003; ENSMUSG00000113949.
DR GeneID; 56214; -.
DR KEGG; mmu:56214; -.
DR UCSC; uc007gdy.1; mouse.
DR CTD; 113178; -.
DR MGI; MGI:1928947; Scamp4.
DR VEuPathDB; HostDB:ENSMUSG00000113949; -.
DR eggNOG; KOG3088; Eukaryota.
DR GeneTree; ENSGT00940000162150; -.
DR HOGENOM; CLU_066546_1_0_1; -.
DR InParanoid; Q9JKV5; -.
DR OMA; MMAIAII; -.
DR PhylomeDB; Q9JKV5; -.
DR TreeFam; TF313797; -.
DR BioGRID-ORCS; 56214; 2 hits in 40 CRISPR screens.
DR ChiTaRS; Scamp4; mouse.
DR PRO; PR:Q9JKV5; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9JKV5; protein.
DR Bgee; ENSMUSG00000113949; Expressed in yolk sac and 63 other tissues.
DR ExpressionAtlas; Q9JKV5; baseline.
DR Genevisible; Q9JKV5; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0055038; C:recycling endosome membrane; IBA:GO_Central.
DR GO; GO:0032588; C:trans-Golgi network membrane; IBA:GO_Central.
DR GO; GO:0030133; C:transport vesicle; ISO:MGI.
DR GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR InterPro; IPR007273; SCAMP.
DR PANTHER; PTHR10687; PTHR10687; 1.
DR Pfam; PF04144; SCAMP; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..230
FT /note="Secretory carrier-associated membrane protein 4"
FT /id="PRO_0000191260"
FT TOPO_DOM 1..39
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..230
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 194
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q969E2"
SQ SEQUENCE 230 AA; 25342 MW; B6FBC08E868387DD CRC64;
MAGKENNFPP LPPFLPLKPC FYQDFSDEIP VEHQVLVKRI YRLWMFYCAT LGVNLVACLA
WWIAGGAGAN FGLALLWLVL FTPCSYVCWF RPAYKAFRAD SSFNFMTFFF IFGAQFVLTV
IQAIGFSGWG ACGWLAAVGF FGTSVGAAVV MLVPAILFSL SALVMAVTIV KVHRIYRGAG
GSLQKAQTEW SAGTWRNPPS REAQFNSFSG NSLPEYPTVP SYSSSGGHWP
