SCAM5_ARATH
ID SCAM5_ARATH Reviewed; 291 AA.
AC Q9SXA5;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Secretory carrier-associated membrane protein 5;
DE Short=Secretory carrier membrane protein 5;
GN Name=SCAMP5; OrderedLocusNames=At1g11180; ORFNames=T28P6.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
CC -!- FUNCTION: Probably involved in membrane trafficking. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9SXA5-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the SCAMP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD49997.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BX817123; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC007259; AAD49997.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28695.1; -; Genomic_DNA.
DR EMBL; BX817123; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; G86245; G86245.
DR RefSeq; NP_172584.1; NM_100990.4. [Q9SXA5-1]
DR AlphaFoldDB; Q9SXA5; -.
DR SMR; Q9SXA5; -.
DR BioGRID; 22899; 1.
DR STRING; 3702.AT1G11180.2; -.
DR iPTMnet; Q9SXA5; -.
DR PaxDb; Q9SXA5; -.
DR PRIDE; Q9SXA5; -.
DR EnsemblPlants; AT1G11180.1; AT1G11180.1; AT1G11180. [Q9SXA5-1]
DR GeneID; 837659; -.
DR Gramene; AT1G11180.1; AT1G11180.1; AT1G11180. [Q9SXA5-1]
DR KEGG; ath:AT1G11180; -.
DR Araport; AT1G11180; -.
DR eggNOG; KOG3088; Eukaryota.
DR HOGENOM; CLU_066546_3_0_1; -.
DR InParanoid; Q9SXA5; -.
DR OMA; EPVDQYN; -.
DR PhylomeDB; Q9SXA5; -.
DR PRO; PR:Q9SXA5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SXA5; baseline and differential.
DR Genevisible; Q9SXA5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055038; C:recycling endosome membrane; IBA:GO_Central.
DR GO; GO:0032588; C:trans-Golgi network membrane; IBA:GO_Central.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR InterPro; IPR007273; SCAMP.
DR PANTHER; PTHR10687; PTHR10687; 1.
DR Pfam; PF04144; SCAMP; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Coiled coil; Cytoplasmic vesicle;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..291
FT /note="Secretory carrier-associated membrane protein 5"
FT /id="PRO_0000304904"
FT TOPO_DOM 1..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..288
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 58..94
FT /evidence="ECO:0000255"
FT MOD_RES 34
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9M5P2"
SQ SEQUENCE 291 AA; 32628 MW; 6C4E5F021A769E76 CRC64;
MGGRYDRNTF DEQDEVNPFA NPGSVPAASN SRLSPLPPEP AGFGYGRTVD IPLDRPGSGA
QDLKKKEKEL QAKEADLRRR EQDLKRKQDA AARAGIVIEA KNWPTFFPLI HHDIANEILV
RLQRLQYIAF ATYLGLVLAL FWNIIAVTTA WIKGEGVTIW LLAVIYFISG VPGGYVLWYR
PLYRAFRSDS AFNFGWFFLF YMLHILFCLF AAVAPPIVFK GKSLAGILPA IDVLSAQALV
GIFYFIGFGL FCLESVVSIW VIQQVYMYFR GSGKADDMRR DAARGAMRAA I
